Browse > Article
http://dx.doi.org/10.7314/APJCP.2016.17.4.1637

Clinical Features of Oxaliplatin Induced Hypersensitivity Reactions and Therapeutic Approaches  

Bano, Nusrat (Pharmacology, King Saud bin Abdulaziz University of Health Sciences)
Najam, Rahila (Pharmacology, University of Karachi)
Qazi, Faaiza (Pharmaceutics, Jinnah Sindh Medical University)
Mateen, Ahmed (Clinical Oncology, Karachi Institute of Radiotherapy and Nuclear Medicine (KIRAN))
Publication Information
Asian Pacific Journal of Cancer Prevention / v.17, no.4, 2016 , pp. 1637-1641 More about this Journal
Abstract
Oxaliplatin, a third generation novel platinum compound is the most effective first line chemotherapeutic agent for colorectal cancer (CRC) in combination with 5FU and leucovorin. It is indicated for pancreatic, gastric and testicular cancers combined with bevacuzimab, capecitabine, irinotecan and other cytotoxic agents. However, moderate to severe hypersensitivity reactions (HSR) during or after oxaliplatin infusion usually require cessation of chemotherapy or substitution of the key therapeutic drug which largely interferes with improved patient prognosis. This mini- review showcases recent and accepted opinions/approaches in oxaliplatin induced HSR management. Physicians and oncologists have varying attitudes regarding the decision to rechallenge the patient after an HSR experience, efficacy of desensitization protocols, effectiveness and selection of drugs for premedication and possibilities of cross sensitivity to other platinum agents (e.g. carboplatin). A brief insight into underlying molecular mechanisms and clinical manifestations of oxaliplatin induced HSR is offered. We have also discussed the management of oxaliplatin induced HSR and risk stratification for a successful and complete chemotherapeutic plan.
Keywords
Oxaliplatin; hypersensitivity reactions; desensitization; management; rechallenge;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Aroldi F, Prochilo T, Bertocchi P, et al (2015). Oxaliplatininduced hypersensitivity reaction: underlying mechanisms and management. J Chemother, 27, 63-6.   DOI
2 Anderson BJ, Peterson LL (2015). Systemic capillary leak syndrome in a patient receiving adjuvant oxaliplatin for locally advanced colon cancer. J Oncol Pharm Pract, 12, 1078155215591388.   DOI
3 Alvarez-Cuesta E, Madrigal-Burgaleta R, Angel-Pereira D, et al (2015). Delving into cornerstones of hypersensitivity to antineoplastic and biological agents: value of diagnostic tools prior to desensitization. Allergy, 70, 784-94.   DOI
4 Arotcarena R, Berthelemy P, Piot M, et al (2001). Readministration of oxaliplatin using a rapid desensitization method after severe anaphylactic reaction. Gastroenterol Clin Biol, 25, 206-7.
5 Alliot C, Messouak D, Beets C, et al (2001). Severe anaphylactic reaction to oxaliplatin. Clin Oncol (R Coll Radiol), 13, 236.
6 Benedik J (2015). Hypersensitivity: case report. Reactions, 1534, 137.
7 Bahl M, Dean T (2015). An intermediate step for the management of hypersensitivity to platinum and taxane chemotherapy. Curr Oncol, 22, 220.
8 Brockow K, Przybilla B, Aberer W, et al (2015). Guideline for the diagnosis of drug hypersensitivity reactions. Allergo J Int, 24, 94-105.
9 Bano N, Najam R, Qazi F, et al (2014). Gastrointestinal Adverse Effects in Advanced Colorectal Carcinoma Patients Treated with Different Schedules of FOLFOX. Asian Pac J Cancer Prev, 15, 8089-93.   DOI
10 Boulanger J, Boursiquot JN, Cournoyer G, et al (2014). Comite de l’evolution des pratiques en oncologie. Curr Oncol, 21, 630-41.   DOI
11 Baretta Z, Falci C, Piva E et al (2013). Fatal oxaliplatin-induced thrombotic thrombocytopenic purpura: a case report. Clin Colorectal Cancer, 4, 294-96.
12 Breslow RG, Caiado J, Castells MC (2009). Acetylsalicylic acid and montelukast block mast cell mediator-related symptoms during rapid desensitization. Ann Allergy Asthma Immunol, 102, 155-60.   DOI
13 Caiado J, Castells M (2015). Presentation and diagnosis of hypersensitivity to platinum drugs. Curr Allergy Asthma Rep, 15, 1-9.   DOI
14 Cheng LC, Chen HH, Lin SE, et al (2008). Hypersensitivity reactions to oxaliplatin: a prospectively collected study of 25 cases treated in one institute. J Soc Colon Rectal Surgeon (Taiwan), 19, 115-21.   DOI
15 Cobo F, De Celis G, Pereira A, et al (2007). Oxaliplatin-induced immune hemolytic anemia: a case report and review of the literature. Anti-Cancer Drugs, 18, 973-6.
16 De Gramont A, Vignoud J, Tournigand C, et al (1997). Oxaliplatin with high-dose leucovorin and 5-fluorouracil 48-hours continuous infusion in pre-treated metastatic colorectal cancer. Eur J Cancer, 33, 214-9.   DOI
17 Curtis BR, Kaliszewski J, Marques MB, et al (2006). Immunemediated thrombocytopenia resulting from sensitivity to oxaliplatin. Am J Hematol, 81, 193-8.
18 Dodgshun AJ, Hansford JR, Cole T, et al (2016). Carboplatin hypersensitivity reactions in pediatric low grade glioma are protocol specific and desensitization shows poor efficacy. Pediatr Blood Cancer, 63, 17-20.   DOI
19 De Vries RS, Mattijssen EJ, van Sorge AA, (2006). Serious delayed hypersensitivity reaction to oxaliplatin. Ann oncol, 17, 1723-4.   DOI
20 Florit-Sureda M, Conde-Estevez D, Vidal J, et al (2015). Hypersensitivity reaction caused by folinic acid administration: a case report and literature review. J Chemother. [Epub ahead of print]
21 Forcello NP, Khubchandani S, Patel SJ, et al (2015). Oxaliplatininduced immune-mediated cytopenias: A case report and literature review. J Oncol Pharm Pract, 21, 148-56.   DOI
22 Giavina-Bianchi P, Aun MV, Galvao VR, et al (2015). Rapid Desensitization in Immediate Hypersensitivity Reaction to Drugs. Curr Treat Options Allergy, 2, 268-85.   DOI
23 Gutierrez M, Pautier P, Lhomme C, et al (2002). Replacement of carboplatin by oxaliplatin may be one solution for patients treated for ovarian carcinoma who are hypersensitive to carboplatin. J Clin Oncol, 20, 353.   DOI
24 Gerard B, Bleiberg H, Van Daele D, et al (1998). Oxaliplatin combined to 5-fluorouracil and folinic acid: an effective therapy in patients with advanced colorectal cancer. Anticancer Drugs, 9, 301-05.   DOI
25 Kurian S, Macintyre J, Mushtaq M, et al (2012). Oxaliplatin induced disseminated intravascular coagulation: A case report and review of literature. World J Gastrointest Oncol, 4, 181.   DOI
26 Ichikawa Y, Goto A, Hirokawa S, et al (2009). Allergic reactions to oxaliplatin in a single institute in Japan. Jpn J Clin Oncol, 39, 616-20.   DOI
27 Kim JY, Lim KH, Song WJ, et al (2015). Breakthrough Reactions during Oxaliplatin Desensitization: An Analysis of 177 Cases. J Allergy Clin Immunol, 135, 112.
28 Kumaran D, Rupa D, Haresh KP, et al (2015). Oxaliplatin induced pulmonary toxicity-a rare phenomenon. Cancer Treat Commun, 4, 203-5.   DOI
29 Lee SY, Kim MY, Kim MH, et al (2013). Hypersensitivity reactions to oxaliplatin: outcomes of premedication and desensitization. J Allergy Clin Immunol, 131, 166.
30 Lundqvist EÅ, Fujiwara K, Seoud M (2015). Principles of chemotherapy. Int J Gynaecol Obstet, 131, 146-9.   DOI
31 Leguy-Seguin V, Jolimoy G, Coudert B, et al (2007). Diagnostic and predictive value of skin testing in platinum salt hypersensitivity, J Allergy Clin Immunol, 119, 726-30.   DOI
32 Lenz HJ (2007). Management and preparedness for infusion and hypersensitivity reactions. Oncologist, 12, 601-9.   DOI
33 Larzilliere I, Brandissou S, Breton P, et al (1999). Anaphylactic reaction to oxaliplatin: a case report. Am J Gastroenterol, 94, 3387-8.   DOI
34 Malkhasyan K, Halene S, Lacy J, et al (2015). Oxaliplatin- Related Acute Disseminated Intravascular Coagulation Syndrome in a Patient With Metastatic Colon Cancer. Clin Colorectal Cancer, 14, 9-12.   DOI
35 Maindrault-Goebel F, Louvet C, Andre T, et al (1999). Oxaliplatin added to the simplified bimonthly leucovorin and 5-fluorouracil regimen as second-line therapy for metastatic colorectal cancer (FOLFOX6). GERCOR. Eur J Cancer, 35, 1338-42.   DOI
36 Madrigal-Burgaleta R, Berges-Gimeno MP, Angel-Pereira D, et al (2013). Hypersensitivity and desensitization to antineoplastic agents: outcomes of 189 procedures with a new short protocol and novel diagnostic tools assessment. Allergy, 68, 853-61.   DOI
37 Meyer L, Zuberbier T, Worm M, et al (2002). Hypersensitivity reactions to oxaliplatin: cross-reactivity to carboplatin and the introduction of a desensitization schedule [letter]. J Clin Oncol, 20, 1146-7.   DOI
38 Markman M, Kennedy A, Webster K, et al (1999). Clinical features of hypersensitivity reactions to carboplatin. J Clin Oncol, 17, 1141-5.   DOI
39 Machover D, Diaz-Rubio E, de Gramont A, et al (1999). Two consecutive phase II studies of oxaliplatin (L-OHP) for treatment of patients with advanced colorectal carcinoma who were resistant to previous treatment with fluoropyrimidines. Ann Oncol, 7, 95-8.
40 Nisi C, Moretti A, Donati D, et al (2015). E18A post-reaction regimen for CRC patients manifesting hypersensitivity to oxaliplatin: an effective alternative not to rule out an important option of treatment. Ann Oncol, 26, 41.
41 Okayama T, Ishikawa T, Sugatani K, et al (2015). Hypersensitivity reactions to oxaliplatin: identifying the risk factors and judging the efficacy of a desensitization protocol. Clin Ther, 37, 1259-69.   DOI
42 Osumi H, Shinozaki E, Kumekawa Y, et al (2013). Three cases of fatal thrombocytopenia after oxaliplatin-based chemotherapy. Gan Kagaku Ryoho, 40, 1557-60.
43 Polyzos A, Tsavaris N, Kosmas C, et al (2001). Hypersensitivity reactions to carboplatin administration are common but not always severe: a 10-year experience. Oncol, 61, 129-33.   DOI
44 Pedersen KS (2015). Safety and efficacy of desensitization protocols for platinum hypersensitivity reactions. Pancreas, 2, 10.
45 Pagani M (2015). Hypersensitivity, urticaria and dyspnoea: 6 case reports. Reactions, 1567, 168-5.
46 Parel M, Ranchon F, Nosbaum A, (2014). Hypersensitivity to oxaliplatin: clinical features and risk factors. BMC Pharmacol Toxicol, 15, 1.   DOI
47 Syrigou EI (2015). Hypersensitivity reaction: case report. Reactions, 1533, 343-10.
48 Santini D, Tonini G, Salerno A, et al (2001). Idiosyncratic reaction after oxaliplatin infusion [letter]. Ann Oncol, 12, 132-3.   DOI
49 Schüll B, Kornek GV, Scheithauer W (2001). Idiosyncratic reaction after oxaliplatin: circumvention by use of a continuous infusional administration schedule. Ann Oncol. 12, 1653-4.
50 Shukunami K, Kurokawa T, Kubo M, et al (1999). Hypersensitivity reaction to carboplatin during treatment for ovarian cancer: successful resolution by replacement with cisplatin. Tumori, 85, 297-8.   DOI
51 Shlebak AA, Clark PI, Green JA (1995).Hypersensitivity and cross reactivity to cisplatin and analogues. Cancer Chemother Pharmacol, 35, 349-51.   DOI
52 Spearing RL, Hickton CM, Sizeland P, et al (1990). Quinineinduced disseminated intravascular coagulation. Lancet, 336, 1535-7.   DOI
53 Tham EH, Cheng YK, Tay MH, et al (2015). Evaluation and management of hypersensitivity reactions to chemotherapy agents. Postgrad Med J, 91, 145-50.   DOI
54 Thomas RR, Quinn MG, Schuler B, et al (2003). Hypersensitivity and idiosyncratic reactions to oxaliplatin. Cancer, 97, 2301-7.   DOI
55 Tamura H (2015). Anaphylactic shock leading to cardiopulmonary arrest: case report. Reactions, 1552, 171-23.
56 Toki MI, Saif MW, Syrigos KN (2014). Hypersensitivity reactions associated with oxaliplatin and their clinical management. Expert Opin Drug Saf, 13, 1545-54.   DOI
57 Taleghani BM, Meyer O, Fontana S, et al (2005). Oxaliplatininduced immune pancytopenia. Transfusion, 45, 704-8.   DOI
58 Tonini G, Santini D, Vincenzi B, et al (2002). Oxaliplatin may induce cytokine-release syndrome in colorectal cancer patients. J Biol Regul Homeost Agents, 16, 105-9.
59 Tournigand C, Maindrault-Goebel F, Louvet C, et al (1998). Severe anaphylactic reactions to oxaliplatin. Eur J Cancer, 34, 1297-8.   DOI
60 Wang AL, Patil SU, Long AA, et al (2015). Risk-stratification protocol for carboplatin and oxaliplatin hypersensitivity: repeat skin testing to identify drug allergy. Ann Allergy Asthma Immunol, 115, 422-8.   DOI
61 Wang JH, King TM, Chang MC, et al (2012). Oxaliplatin-induced severe anaphylactic reactions in metastatic colorectal cancer: case series analysis. World J Gastroenterol, 18, 5427-33.   DOI
62 Yamauchi H, Goto T, Takayoshi K, et al (2015). A retrospective analysis of the risk factors for allergic reactions induced by the administration of oxaliplatin. Eur J Cancer Care, 24, 111-6.   DOI
63 Yanagihara Y (2015). Allergic reaction and fever: 2 case reports. Reactions, 1555, 147-3.
64 Zanotti KM, Rybicki LA, Kennedy AW, et al (2001). Carboplatin skin testing: a skin-testing protocol for predicting hypersensitivity to carboplatin chemotherapy. J Clin Oncol, 19, 3126-9.   DOI
65 Yoshida Y, Hirata K, Matsuoka H, et al (2015). A single-arm Phase II validation study of preventing oxaliplatin-induced hypersensitivity reactions by dexamethasone: the aVOiD trial. Drug Des Devel Ther, 9, 6067-73.