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http://dx.doi.org/10.7314/APJCP.2016.17.3.1103

Effects of a Multikinase Inhibitor Motesanib (AMG 706) Alone and Combined with the Selective DuP-697 COX-2 Inhibitor on Colorectal Cancer Cells  

Kaya, Tijen Temiz (Department of Pharmacology, Faculty of Pharmacy, Cumhuriyet University)
Altun, Ahmet (Department of Pharmacology, Faculty of Pharmacy, Cumhuriyet University)
Turgut, Nergiz Hacer (Department of Gastroenterology, Faculty of Pharmacy, Cumhuriyet University)
Ataseven, Hilmi (Department of Pharmacology, Faculty of Pharmacy, Cumhuriyet University)
Koyluoglu, Gokhan (Department of Pediatric Surgery, Faculty of Medicine, Cumhuriyet University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.17, no.3, 2016 , pp. 1103-1110 More about this Journal
Abstract
In the present study, we investigated the effects of motesanib (AMG 706), a multikinase inhibitor alone and in combination with DuP-697, an irreversible selective inhibitor of COX-2, on cell proliferation, angiogenesis, and apoptosis induction in a human colorectal cancer cell line (HT29). Real time cell analysis (RTCA, Xcelligence system) was used to determine the effects on colorectal cancer cell proliferation. Apoptosis was assessed with annexin V staining and angiogenesis was determined with chorioallantoic membrane model. We found that motesanib alone exerted antiproliferative, antiangiogenic and apoptotic effects on HT29 colorectal cancer cells. Combination with DUP-697 increased the antiproliferative, antiangiogenic and apoptotic effects. Results of this study indicate that motesanib may be a good choice in treatment of colorectal tumors. In addition, the increased effects of combination of motesanib with DuP-697 raise the possibility of using lower doses of these drugs and therefore avoid/minimize the dose-dependent side effects generally observed.
Keywords
Colorectal cancer; motesanib; multikinase inhibitor; COX-2 inhibition;
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