Browse > Article
http://dx.doi.org/10.7314/APJCP.2016.17.2.739

Preliminary Study of the GSTM1 Null Polymorphism and History of Tobacco Smoking among Oral Cancer Patients in Northeastern Thailand  

Natphopsuk, Sitakan (Department of Physiology, Khon Kaen University)
Settheetham-Ishida, Wannapa (Department of Physiology, Khon Kaen University)
Phuthong, Sophida (Department of Physiology, Khon Kaen University)
Ishida, Takafumi (Department of Biological Sciences, Graduate School of Science, The University of Tokyo)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.17, no.2, 2016 , pp. 739-742 More about this Journal
Abstract
Risks with GSTM1 genotypes and potential roles of smoking in the susceptibility to oral squamous cell carcinoma (OSCC) were studied in Northeastern Thailand. Study subjects were 79 histologically-confirmed OSCC cases (31 men, 48 women) and 79 age- and sex-matched healthy controls ranging in age from 25 to 84 years. GSTM1 genotyping was achieved by two independent PCR assays. The GSTM1 null allele and the homozygous genotype did not increase risk of OSCC vs the wild type allele and the remaining genotypes. When the focus was on the smoking habit, male subjects who smoked ${\geq}10$ or ${\geq}35$ years were at significantly increased risk for OSCC with adjusted ORs of 4.88 [95%CI, 1.41-16.87, p=0.012] or 4.94 [95%CI, 1.62-15.12, p=0.005], respectively. A higher risk for OSCC was found for smoking amount; those who smoked >5 or >10 pack-years were at a higher risk with adjusted OR of 4.46 [95%CI; 1.45-13.74, p=0.009] or 3.89 [95%CI; 1.34-11.28, p=0.012], respectively. There are certain smoking patterns that give greater risks and thus both smoking duration and pack-years should be taken into consideration in tobacco related cancer prevention.
Keywords
Oral cancer; GSTM1; tobacco smoking; Northeast Thailand;
Citations & Related Records
Times Cited By KSCI : 7  (Citation Analysis)
연도 인용수 순위
1 Deakin M, Elder J, Hendrickse C, et al (1996). Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer:studies of interactions with GSTM1 in lung, oral, gastric and colorectal cancers. Carcinogenesis, 17, 881-4   DOI
2 Drummond SN, De Marco L, Noronha JC, Gomez RS. (2004) GSTM1 polymorphism and oral squamous cell carcinoma. Oral Oncol, 40, 52-5.   DOI
3 Gronau S, Koenig-Greger D, Jerg M, Riechelmann H (2003). GSTM1 enzyme concentration and enzyme activity in correlation to the genotype of detoxification enzymes in squamous cell carcinoma of the oral cavity. Oral Dis, 9, 62-7.   DOI
4 Zhang ZJ, Hao K, Shi R, et al (2011). Glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) null polymorphisms, smoking, and their interaction in oral cancer: a HuGE review and meta-analysis. Am J Epidemiol, 173, 847-57   DOI
5 Zhao SF, Yang XD, Lu MX, et al (2014). GSTM1 null polymorphisms and oral cancer risk: a meta-analysis. Tumour Biol, 35, 287-93.   DOI
6 Larizadeh MH, Shabani M (2012). Survival following non surgical treatments for oral cancer: a single institutional result. Asian Pac J Cancer Prev, 13, 4133-6.   DOI
7 Hahn M, Hagedorn G, Kuhlisch E, Schackert HK, Eckelt U (2002). Genetic polymorphisms of drug-metabolizing enzymes and susceptibility to oral cavity cancer. Oral Oncol, 38, 486-90.   DOI
8 Hayes JD, Pulford DJ (1995). The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol, 30, 445-600.   DOI
9 Jourenkova-Mironova N, Voho A, Bouchardy C, et al (1999). Glutathione S-transferase GSTM1, GSTM3, GSTP1 and GSTT1 genotypes and the risk of smoking-related oral and pharyngeal cancers. Int J Cancer, 81, 44-8.   DOI
10 Liu X, Li Z, Zhang Z, et al (2014). Meta-analysis of GSTM1 null genotype and lung cancer risk in Asians. Med Sci Monit, 20, 1239-45.   DOI
11 Loyha K, Vatanasapt P, Promthet S, Parkin DM (2012). Risk factors for oral cancer in northeast Thailand. Asian Pac J Cancer Prev, 13, 5087-90.   DOI
12 Mukherjee JJ, Kumar S (2010). Phenolic fraction of tobacco smoke condensate potentiates benzo[a]pyerene diol epoxideinduced cell transformation: role of protein kinase C. Mutat Res, 696, 89-94.   DOI
13 Nagler R, Ben-Izhak O, Savulescu D, et al (2010). Oral cancer, cigarette smoke and mitochondrial 18kDa translocator protein (TSPO) - In vitro, in vivo, salivary analysis. Biochim Biophys Acta, 1802, 454-61.   DOI
14 Nair UJ, Nair J, Mathew B, Bartsch H (1999). Glutathione S-transferase M1 and T1 null genotypes as risk factors for oral leukoplakia in ethnic Indian betel quid/tobacco chewers. Carcinogenesis, 20, 743-8.   DOI
15 Rodriguez T, Altieri A, Chatenoud L, et al (2004). Risk factors for oral and pharyngeal cancer in young adults. Oral Oncol, 40, 207-13.   DOI
16 Natphopsuk S, Settheetham-Ishida W, Settheetham D, Ishida T (2015). Lack of Participation of the GSTM1 polymorphism in cervical cancer development in northeast Thailand. Asian Pac J Cancer Prev, 16, 1935-7.   DOI
17 Peng J, Liu HZ, Zhu YJ (2014). Null Glutathione S-transferase T1 and M1 genotypes and oral cancer susceptibility in China and India--a meta-analysis. Asian Pac J Cancer Prev, 15, 287-90   DOI
18 Petti S (2009). Lifestyle risk factors for oral cancer. Oral Oncol, 45, 340-50.   DOI
19 Rogers SN, Brown JS, Woolgar JA, et al (2009). Survival following primary surgery for oral cancer. Oral Oncol, 45, 201-11.   DOI
20 Roodi N, Dupont WD, Moore JH, Parl FF (2004). Association of homozygous wild-type glutathione S-transferase M1 genotype with increased breast cancer risk. Cancer Res, 64, 1233-6.   DOI
21 Saitou M, Ishida T (2015). Distributions of the GSTM1 and GSTT1 null genotypes worldwide are characterized by latitudinal clines. Asian Pac J Cancer Prev, 16, 355-61.   DOI
22 Samanic C, Kogevinas M, Dosemeci M, et al (2006). Smoking and bladder cancer in Spain: effects of tobacco type, timing, environmental tobacco smoke, and gender. Cancer Epidemiol Biomarkers Prev, 15, 1348-54.   DOI
23 Sato M, Sato T, Izumo T, Amagasa T (2000). Genetically high susceptibility to oral squamous cell carcinoma in terms of combined genotyping of CYP1A1 and GSTM1 genes. Oral Oncol, 36, 267-71.   DOI
24 Sreelekha TT, Ramadas K, Pandey M, et al (2001). Genetic polymorphism of CYP1A1, GSTM1 and GSTT1 genes in Indian oral cancer. Oral Oncol, 37, 593-8.   DOI
25 Schnakenberg E, Breuer R, Werdin R, Dreikorn K, Schloot W (2000). Susceptibility genes: GSTM1 and GSTM3 as genetic risk factors in bladder cancer. Cytogenet Cell Genet, 91, 234-8.   DOI
26 Shields PG (2002). Molecular epidemiology of smoking and lung cancer. Oncogene, 21, 6870-6.   DOI
27 Sobue T, Yamamoto S, Hara M, et al (2002). Cigarette smoking and subsequent risk of lung cancer by histologic type in middle-aged Japanese men and women: the JPHC study. Int J Cancer, 99, 245-51.   DOI
28 Tanimoto K, Hayashi S, Yoshiga K, Ichikawa T (1999). Polymorphisms of the CYP1A1 and GSTM1 gene involved in oral squamous cell carcinoma in association with a cigarette dose. Oral Oncol, 35, 191-6.   DOI
29 Tiwawech D, Srivatanakul P, Karalak A, Ishida T (2005). Glutathione S-transferase M1 gene polymorphism in Thai nasopharyngeal carcinoma. Asian Pac J Cancer Prev, 6, 270-5.
30 Varela-Lema L, Ruano-Ravina A, Juiz Crespo MA, et al (2008). CYP1A1, mEH, and GSTM1 polymophisms and risk of oral and pharyngeal cancer: a spanish case-control study. J Oncol, 741310.
31 Vatanasapt P, Suwanrungruang K, Kamsa-Ard S, et al (2011). Epidemiology of oral and pharyngeal cancers in Khon Kaen, Thailand: a high incidence in females. Asian Pac J Cancer Prev, 12, 2505-8.
32 Zakiullah, Ahmadullah, Khisroon M, et al (2015). Genetic susceptibility to oral cancer due to combined effects of GSTT1, GSTM1 and CYP1A1 gene variants in tobacco addicted patients of pashtun ethnicity of khyber pakhtunkhwa province of Pakistan. Asian Pac J Cancer Prev, 16, 1145-50.   DOI