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http://dx.doi.org/10.7314/APJCP.2016.17.1.235

Incidence of Active HCV infection amongst Blood Donors of Mardan District, Pakistan  

Karim, Fawad (Department of Biotechnology, Bacha Khan University Charsadda)
Nasar, Abu (Department of Biotechnology, Bacha Khan University Charsadda)
Alam, Ibrar (Department of Biotechnology, Bacha Khan University Charsadda)
Alam, Iftikhar (Department of Human Nutrition and Dietetics (HND), Bacha Khan University Charsadda)
Hassan, Said (Center of Biotechnology and Microbiology, University of Peshawar)
Gul, Rahmat (Department of Human Nutrition and Dietetics (HND), Bacha Khan University Charsadda)
Ullah, Sana (Department of Animal Science Quaid-i-Azam University Islamabad)
Rizwan, Muhammad (Center of Biotechnology and Microbiology, University of Peshawar)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.17, no.1, 2016 , pp. 235-238 More about this Journal
Abstract
Hepatitis C is an ailment of liver caused by hepatitis C virus (HCV) infection. About 3% of the world population is infected by this virus. HCV infection is a leading reason for liver cirrhosis and therefore a major source of hepatocellular carcinoma. The study focused on the incidence of active HCV infection in blood donors of Mardan district of KPK, Pakistan. A total of 5318 blood donors were inspected for the presence of anti-HCV antibodies and HCV-RNA using ICT (immune-chromatographic test), ELISA and RT-PCR at Mardan Medical Complex (MMC), Mardan. Out of these, 157 (2.95%) were positive by ICT, 60 (1.12%) by ELISA and 56 (1.05%) for HCV-RNA. The frequency of active HCV infectivity amongst the blood donors from district Mardan, KPK Pakistan was 1.05 %. Application of strict measures during blood donor selection and use of proper screening assays such as ELISA in place of ICT devices can give a more accurate picture so that the incidence of this viral infection in HCV negative blood recipients can be reduced.
Keywords
HCV; ELISA; RT-PCR; viral infection rates;
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