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http://dx.doi.org/10.22034/APJCP.2016.17.12.5047

Anti-Oxidant, Pro-Oxidant and Anti-Inflammatory Effects of Unpolished Rice Relevant to Colorectal Cancer  

Suwannalert, Prasit (Department of Pathobiology, Faculty of Science, Mahidol University)
Payuhakrit, Witchuda (Department of Pathobiology, Faculty of Science, Mahidol University)
Koomsang, Thidarat (Department of Pathobiology, Faculty of Science, Mahidol University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.17, no.12, 2016 , pp. 5047-5056 More about this Journal
Abstract
Colorectal cancer (CRC) is a major worldwide health problem owing to its high prevalence and mortality rates. Carcinogenesis in the colon is a multistage and multifactorial process. An imbalance between free radical exposure and anti-oxidant defense systems may leads to oxidative stress and attack of macromolecules which can alter signal transduction pathways and gene expression. Consequently, oxidative damage can lead to cellular dysfunction and contribute to pathophysiological processes in a variety of diseases including CRC. One factor tightly associated with CRC is chronic inflammation, which can be present from the earliest stage of tumor onset. Unpolished rice is an attractive chemoprevention in CRC due to their anti-oxidant and anti-inflammatory activities. The aim of this paper is to review evidence linking oxidative stress and inflammation to CRC and to provide essential background information for understanding future research on oxidative stress and inflammation on CRC. Mechanisms of action of unpolished rice in CRC carcinogenesis are also discussed.
Keywords
Colorectal cancer; oxidative stress; anti-oxidants; inflammation; unpolished rice;
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1 Holmgren A, Johansson C, Berndt C, et al (2005). Thiol redox control via thioredoxin and glutaredoxin systems. Biochem Soc Trans, 33, 1375-7.
2 Hyun JW, Chung HS (2004). Cyanidin and Malvidin from Oryza sativa cv. Heugjinjubyeo mediate cytotoxicity against human monocytic leukemia cells by arrest of G(2)/M phase and induction of apoptosis. J Agric Food Chem, 52, 2213-7.   DOI
3 Sturlan S, Oberhuber G, Beinhauer BG, et al (2001). Interleukin- 10-deficient mice and inflammatory bowel disease associated cancer development. Carcinogenesis, 22, 665-71.   DOI
4 Summart R, Chewonarin T (2014). Purple rice extract supplemented diet reduces DMH- induced aberrant crypt foci in the rat colon by inhibition of bacterial beta-glucuronidase. Asian Pac J Cancer Prev, 15, 749-55.   DOI
5 Surh YJ (2003). Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer, 3, 768-80.   DOI
6 Suwannalert P, Rattanachitthawat S (2011). High levels of phytophenolics and antioxidant activities in Oryza Sativa - unpolished Thai rice strain of Leum Phua. Trop J Pharm Res, 10, 431-6.
7 Suwannalert P, Rattanachitthawat S, Chaiyasut C, et al (2010). High levels of 25-hydroxyvitamin D 3 [25(OH)D 3] and $\alpha$-tocopherol prevent oxidative stress in rats that consume Thai brown rice. J Med Plants Res, 4, 120-4.
8 Takahashi M, Wakabayashi K (2004). Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents. Cancer Sci, 95, 475-80.   DOI
9 Tammasakchai A, Chaiyasut C, Riengrojpitak S, et al (2015). Unpolished Thai rice prevents ACF formation and dysplastic progression in AOM-induced rats and induces apoptosis through redox alteration in CaCo-2 cells. Asian Pac J Cancer Prev, 16, 2827-32.   DOI
10 Tammasakchai A, Reungpatthanaphong S, Chaiyasut C, et al (2012). Red strain oryza sativa-unpolished thai rice prevents oxidative stress and colorectal aberrant crypt foci formation in rats. Asian Pac J Cancer Prev, 13, 1929-33.   DOI
11 Jiang W, Yu X, Ren G (2013). Inhibition effects of black rice pericarp extracts on cell proliferation of PC-3 cells. Wei Sheng Yan Jiu, 42, 474-7.
12 Itoh M, Nishibori N, Sagara T, et al (2012). Extract of fermented brown rice induces apoptosis of human colorectal tumor cells by activating mitochondrial pathway. Phytother Res, 26, 1661-6.   DOI
13 Iyer A, Hatta M, Usman R, et al (2007). Serum levels of interferon-gamma, tumour necrosis factor-alpha, soluble interleukin-6R and soluble cell activation markers for monitoring response to treatment of leprosy reactions. Clin Exp Immunol, 150, 210-6.   DOI
14 Jacobs DR, Steffen LM (2003). Nutrients, foods, and dietary patterns as exposures in research: a framework for food synergy. Am J Clin Nutr, 78, 508-13.   DOI
15 Joubert E, Winterton P, Britz TJ, et al (2005). Antioxidant and pro-oxidant activities of aqueous extracts and crude polyphenolic fractions of rooibos (Aspalathus linearis). J Agric Food Chem, 53, 10260-7.   DOI
16 Kantola T, Klintrup K, Vayrynen JP, et al (2012). Stagedependent alterations of the serum cytokine pattern in colorectal carcinoma. Br J Cancer, 107, 1729-36.   DOI
17 Henderson AJ, Ollila CA, Kumar A, et al (2012). Chemopreventive properties of dietary rice bran: current status and future prospects. Adv Nutr, 3, 643-53.   DOI
18 Pan MH, Lai CS, Wu JC, et al (2011). Molecular mechanisms for chemoprevention of colorectal cancer by natural dietary compounds. Mol Nutr Food Res, 55, 32-45.   DOI
19 Tan BL, Norhaizan ME, Huynh K, et al (2015). Brewers' rice modulates oxidative stress in azoxymethane-mediated colon carcinogenesis in rats. World J Gastroenterol, 21, 8826-35.   DOI
20 Pai R, Soreghan B, Szabo IL, et al (2002). Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy. Nat Med, 8, 289-93.   DOI
21 Pandey KB, Rizvi SI (2009). Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev, 2, 270-8.   DOI
22 Pandurangan AK (2013). Potential targets for prevention of colorectal cancer: a focus on PI3K/Akt/mTOR and Wnt pathways. Asian Pac J Cancer Prev, 14, 2201-5.   DOI
23 Pandurangan AK, Dharmalingam P, Ananda Sadagopan SK, et al (2012). Effect of luteolin on the levels of glycoproteins during azoxymethane-induced colon carcinogenesis in mice. Asian Pac J Cancer Prev, 13, 1569-73.   DOI
24 Philip M, Rowley DA, Schreiber H (2004). Inflammation as a tumor promoter in cancer induction. Semin Cancer Biol, 14, 433-9.   DOI
25 Kawasaki T, Nosho K, Ohnishi M, et al (2007). Correlation of beta-catenin localization with cyclooxygenase-2 expression and CpG island methylator phenotype (CIMP) in colorectal cancer. Neoplasia, 9, 569-77.   DOI
26 Pandurangan AK, Esa NM (2013). Dietary non-nutritive factors in targeting of regulatory molecules in colorectal cancer: an update. Asian Pac J Cancer Prev, 14, 5543-52.   DOI
27 Peddareddigari VG, Wang D, Dubois RN (2010). The tumor microenvironment in colorectal carcinogenesis. Cancer Microenviron, 3, 149-66.   DOI
28 Perse M (2013). Oxidative stress in the pathogenesis of colorectal cancer: cause or consequence?. Biomed Res Int, 2013, 725710.
29 Pham-Huy LA, He H, Pham-Huy C (2008). Free radicals, antioxidants in disease and health. Int J Biomed Sci, 4, 89-96.
30 Poljsak B, Dahmane R (2012). Free radicals and extrinsic skin aging. Dermatol Res Pract, 2012, 135206.
31 Terzic J, Grivennikov S, Karin E, et al (2010). Inflammation and colon cancer. Gastroenterology, 138, 2101-14.   DOI
32 Tanaka T (2009). Colorectal carcinogenesis: Review of human and experimental animal studies. J Carcinog, 8, 5.   DOI
33 Tanaka T (2012). Preclinical cancer chemoprevention studies using animal model of inflammation-associated colorectal carcinogenesis. Cancers (Basel), 4, 673-700.   DOI
34 Tantamango YM, Knutsen SF, Beeson WL, et al (2011). Foods and food groups associated with the incidence of colorectal polyps: the adventist health study. Nutr Cancer, 63, 565-72.   DOI
35 Toiyama Y, Miki C, Inoue Y, et al (2010). Loss of tissue expression of interleukin-10 promotes the disease progression of colorectal carcinoma. Surg Today, 40, 46-53.   DOI
36 Trachootham D, Lu W, Ogasawara MA, et al (2008). Redox regulation of cell survival. Antioxid Redox Signal, 10, 1343-74.   DOI
37 Traverso N, Ricciarelli R, Nitti M, et al (2013). Role of glutathione in cancer progression and chemoresistance. Oxid Med Cell Longev, 2013, 972913.
38 Tan BL, Norhaizan ME, Pandurangan AK, et al (2016). Brewers' rice attenuated aberrant crypt foci developing in colon of azoxymethane-treated rats. Pak J Pharm Sci, 29, 205-12.
39 Valavanidis A, Vlachogianni T, Fiotakis K (2009). Tobacco smoke: involvement of reactive oxygen species and stable free radicals in mechanisms of oxidative damage, carcinogenesis and synergistic effects with other respirable particles. Int J Environ Res Public Health, 6, 445-62.   DOI
40 Balkwill F, Mantovani A (2001). Inflammation and cancer: back to Virchow?. Lancet, 357, 539-45.   DOI
41 Banjerdpongchai R, Wudtiwai B, Sringarm K (2014). Cytotoxic and apoptotic-inducing effects of purple rice extracts and chemotherapeutic drugs on human cancer cell lines. Asian Pac J Cancer Prev, 14, 6541-8.
42 Bastide NM, Pierre FH, Corpet DE (2011). Heme iron from meat and risk of colorectal cancer: a meta-analysis and a review of the mechanisms involved. Cancer Prev Res (Phila), 4, 177-84.   DOI
43 Bhattacharyya A, Chattopadhyay R, Mitra S, et al (2014). Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiol Rev, 94, 329-54.   DOI
44 Bird RP (1995). Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett, 93, 55-71.   DOI
45 Bird RP, Good CK (2000). The significance of aberrant crypt foci in understanding the pathogenesis of colon cancer. Toxicol Lett, 112, 395-402.
46 Bretthauer M (2010). Evidence for colorectal cancer screening. Best Pract Res Clin Gastroenterol, 24, 417-25.   DOI
47 Brown JR, DuBois RN (2005). COX-2: a molecular target for colorectal cancer prevention. J Clin Oncol, 23, 2840-55.   DOI
48 Archer MC, Bruce WR, Chan CC, et al (1992). Aberrant crypt foci and microadenoma as markers for colon cancer. Environ Health Perspect, 98, 195-7.
49 Candela M, Turroni S, Biagi E, et al (2014). Inflammation and colorectal cancer, when microbiota-host mutualism breaks. World J Gastroenterol, 20, 908-22.   DOI
50 Kazem A, Sayed KE, Kerm YE (2014). Prognostic significance of COX-2 and $\beta$-catenin in colorectal carcinoma. Alexandria Med J, 50, 211-20.   DOI
51 Kelly MR, Xu J, Alexander KE, et al (2001). Disparate effects of similar phenolic phytochemicals as inhibitors of oxidative damage to cellular DNA. Mutat Res, 485, 309-18.   DOI
52 Khadem S, Marles RJ (2010). Monocyclic phenolic acids; hydroxy- and polyhydroxybenzoic acids: occurrence and recent bioactivity studies. Molecules, 15, 7985-8005.   DOI
53 Khansari N, Shakiba Y, Mahmoudi M (2009). Chronic inflammation and oxidative stress as a major cause of agerelated diseases and cancer. Recent Pat Inflamm Allergy Drug Discov, 3, 73-80.   DOI
54 Kim YS, Milner JA (2007). Dietary modulation of colon cancer risk. J Nutr, 137, 2576-9.   DOI
55 King A, Young G (1999). Characteristics and occurrence of phenolic phytochemicals. J Am Diet Assoc, 99, 213-8.   DOI
56 Kinugasa T, Akagi Y (2016). Status of colitis-associated cancer in ulcerative colitis. World J Gastrointest Oncol, 8, 351-7.   DOI
57 Kinzler KW, Vogelstein B (1996). Lessons from hereditary colorectal cancer. Cell, 87, 159-70.   DOI
58 Knupfer H, Preiss R (2010). Serum interleukin-6 levels in colorectal cancer patients--a summary of published results. Int J Colorectal Dis, 25, 135-40.   DOI
59 Koehne CH, Dubois RN (2004). COX-2 inhibition and colorectal cancer. Semin Oncol, 31, 12-21.   DOI
60 Visco C, Vassilakopoulos TP, Kliche KO, et al (2004). Elevated serum levels of IL-10 are associated with inferior progression-free survival in patients with Hodgkin's disease treated with radiotherapy. Leuk Lymphoma, 45, 2085-92.   DOI
61 Rizzo AM, Berselli P, Zava S, et al (2010). Endogenous antioxidants and radical scavengers. Adv Exp Med Biol, 698, 52-67.
62 Cappell MS (2005). The pathophysiology, clinical presentation, and diagnosis of colon cancer and adenomatous polyps. Med Clin North Am, 89, 1-42.   DOI
63 Rajamanickam S, Agarwal R (2008). Natural products and colon cancer: current status and future prospects. Drug Dev Res, 69, 460-71.   DOI
64 Rakoff-Nahoum S (2006). Why cancer and inflammation? Yale J Biol Med, 79, 123-30.
65 Raskov H, Pommergaard HC, Burcharth J, et al (2014). Colorectal carcinogenesis-update and perspectives. World J Gastroenterol, 20, 18151-64.   DOI
66 Rattanachitthawat S, Suwannalert P, Riengrojpitak S, et al (2010). Phenolic content and antioxidant activities in red unpolished Thai rice prevents oxidative stress in rats. J Med Plants Res, 4, 796-801.
67 Reungpatthanaphong S, Chaiyasut C, Sirilun S, et al (2016). Unpolished thai rice prevents Aberrant Crypt Foci Formation through the Invovement of catenin and COX2 Expression in AzoxymethaneTreated Rats. Asian Pac J Cancer Prev, 17, 3551-8.
68 Rice-Evans CA, Miller NJ, Paganga G (1996). Structureantioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med, 20, 933-56.   DOI
69 Porta C, Larghi P, Rimoldi M, et al (2009). Cellular and molecular pathways linking inflammation and cancer. Immunobiology, 214, 761-77.   DOI
70 Roncucci L, Medline A, Bruce WR (1991). Classification of aberrant crypt foci and microadenomas in human colon. Cancer Epidemiol Biomarkers Prev, 1, 57-60.
71 Sarris AH, Kliche KO, Pethambaram P, et al (1999). Interleukin-10 levels are often elevated in serum of adults with Hodgkin's disease and are associated with inferior failure-free survival. Ann Oncol, 10, 433-40.   DOI
72 Westermarck J, Kahari VM (1999). Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J, 13, 781-92.   DOI
73 Waldner MJ, Foersch S, Neurath MF (2012). Interleukin-6-a key regulator of colorectal cancer development. Int J Biol Sci, 8, 1248-53.   DOI
74 Wang J, Yi J (2008). Cancer cell killing via ROS: to increase or decrease, that is the question. Cancer Biol Ther, 7, 1875-84.   DOI
75 Watson WH, Cai J, Jones DP (2000). Diet and apoptosis. Annu Rev Nutr, 20, 485-505.   DOI
76 Xiao H, Hao X, Simi B, et al (2008). Green tea polyphenols inhibit colorectal aberrant crypt foci (ACF) formation and prevent oncogenic changes in dysplastic ACF in azoxymethane-treated F344 rats. Carcinogenesis, 29, 113-9.
77 Zhao S, Wu D, Wu P, et al (2015). Serum IL-10 Predicts Worse Outcome in Cancer Patients: A Meta-Analysis. PLoS One, 10, e0139598.   DOI
78 Chien CC, Wu MS, Shen SC, et al (2014). Activation of JNK contributes to evodiamine-induced apoptosis and G(2)/M arrest in human colorectal carcinoma cells: A structureactivity study of evodiamine. PLoS One, 9.
79 Chen LJ, Lee DS, Song ZP, et al (2004). Gene Flow from Cultivated Rice (Oryza sativa) to its Weedy and Wild Relatives. Ann Bot, 93, 67-73.   DOI
80 Chiang AN, Wu HL, Yeh HI, et al (2006). Antioxidant effects of black rice extract through the induction of superoxide dismutase and catalase activities. Lipids, 41, 797-803.   DOI
81 Chindaprasirt J, Sookprasert A, Wirasorn K, et al (2012). Cost of colorectal cancer care in hospitalized patients of Thailand. J Med Assoc Thai, 95, 196-200.
82 Chung YC, Chang YF (2003). Serum interleukin-6 levels reflect the disease status of colorectal cancer. J Surg Oncol, 83, 222-6.   DOI
83 Cui G, Florholmen J (2008). Polarization of cytokine profile from Th1 into Th2 along colorectal adenoma-carcinoma sequence: implications for the biotherapeutic target?. Inflamm Allergy Drug Targets, 7, 94-7.   DOI
84 Liang T, Zhang X, Xue W, et al (2014). Curcumin induced human gastric cancer BGC-823 cells apoptosis by ROS-mediated ASK1-MKK4-JNK stress signaling pathway. Int J Mol Sci, 15, 15754-65.   DOI
85 Kraus S, Arber N (2009). Inflammation and colorectal cancer. Curr Opin Pharmacol, 9, 405-10.   DOI
86 Kundu JK, Surh YJ (2008). Inflammation: gearing the journey to cancer. Mutat Res, 659, 15-30.   DOI
87 Labieniec M, Gabryelak T (2006). Study of interactions between phenolic compounds and H2O2 or Cu(II) ions in B14 Chinese hamster cells. Cell Biol Int, 30, 761-8.   DOI
88 Lobo V, Patil A, Phatak A, et al (2010). Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev, 4, 118-26.   DOI
89 Long LH, Clement MV, Halliwell B (2000). Artifacts in cell culture: rapid generation of hydrogen peroxide on addition of (-)-epigallocatechin, (-)-epigallocatechin gallate, (+)-catechin, and quercetin to commonly used cell culture media. Biochem Biophys Res Commun, 273, 50-3.   DOI
90 Loo G (2003). Redox-sensitive mechanisms of phytochemicalmediated inhibition of cancer cell proliferation (review). J Nutr Biochem, 14, 64-73.   DOI
91 Lu H, Ouyang W, Huang C (2006). Inflammation, a key event in cancer development. Mol Cancer Res, 4, 221-33.   DOI
92 Kondo S, Toyokuni S, Iwasa Y, et al (1999). Persistent oxidative stress in human colorectal carcinoma, but not in adenoma. Free Radic Biol Med, 27, 401-10.   DOI
93 Schatzkin A, Park Y, Leitzmann MF, et al (2008). Prospective study of dietary fiber, whole grain foods, and small intestinal cancer. Gastroenterology, 135, 1163-7.   DOI
94 Zhao X, Sun H, Hou A, et al (2005). Antioxidant properties of two gallotannins isolated from the leaves of Pistacia weinmannifolia. Biochim Biophys Acta, 1725, 103-10.   DOI
95 Dai J, Mumper RJ (2010). Plant phenolics: extraction, analysis and their antioxidant and anticancer properties. Molecules, 15, 7313-52.   DOI
96 Dayem AA, Choi HY, Kim JH, et al (2010). Role of oxidative stress in stem, cancer, and cancer stem cells. Cancers (Basel), 2, 859-84.   DOI
97 Center MM, Jemal A, Smith RA, et al (2009). Worldwide variations in colorectal cancer. CA Cancer J Clin, 59, 366-78.   DOI
98 De Vita F, Orditura M, Lieto E, et al (2004). Elevated perioperative serum vascular endothelial growth factor levels in patients with colon carcinoma. Cancer, 100, 270-8.   DOI
99 Luceri C, Caderni G, Sanna A, et al (2002). Red wine and black tea polyphenols modulate the expression of cycloxygenase-2, inducible nitric oxide synthase and glutathione-related enzymes in azoxymethane-induced f344 rat colon tumors. J Nutr, 132, 1376-9.   DOI
100 Saxena A, Baliga MS, Ponemone V, et al (2013). Mucus and adiponectin deficiency: role in chronic inflammation-induced colon cancer. Int J Colorectal Dis, 28, 1267-79.   DOI
101 Sengupta N, Yee E, Feuerstein JD (2016). Colorectal Cancer Screening in Inflammatory Bowel Disease. Dig Dis Sci, 61, 980-9.   DOI
102 Shafie NH, Mohd Esa N, Ithnin H, et al (2013). Preventive inositol hexaphosphate extracted from rice bran inhibits colorectal cancer through involvement of Wnt/beta-catenin and COX-2 pathways. Biomed Res Int, 2013, 681027.
103 Shahidi F, Wanasundara PK (1992). Phenolic antioxidants. Crit Rev Food Sci Nutr, 32, 67-103.   DOI
104 Shao Y, Xu F, Sun X, et al (2014). Phenolic acids, anthocyanins, and antioxidant capacity in rice (Oryza sativa L.) grains at four stages of development after flowering. Food Chem, 143, 90-6.   DOI
105 Siegel RL, Miller KD, Jemal A (2015). Cancer statistics, 2015. CA Cancer J Clin, 65, 5-29.   DOI
106 Slattery ML, Edwards SL, Boucher KM, et al (1999). Lifestyle and colon cancer: an assessment of factors associated with risk. Am J Epidemiol, 150, 869-77.   DOI
107 Sompong R, Siebenhandl-Ehn S, Linsberger-Martin G, et al (2011). Physicochemical and antioxidative properties of red and black rice varieties from Thailand, China and Sri Lanka. Food Chem, 124, 132-40.   DOI
108 Soria JC, Moon C, Kemp BL, et al (2003). Lack of interleukin-10 expression could predict poor outcome in patients with stage I non-small cell lung cancer. Clin Cancer Res, 9, 1785-91.
109 Sporn MB, Suh N (2000). Chemoprevention of cancer. Carcinogenesis, 21, 525-30.   DOI
110 de Waal Malefyt R, Abrams J, Bennett B, et al (1991). Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med, 174, 1209-20.   DOI
111 Dennis KL, Blatner NR, Gounari F, et al (2013). Current status of interleukin-10 and regulatory T-cells in cancer. Curr Opin Oncol, 25, 637-45.   DOI
112 Fleming M, Ravula S, Tatishchev SF, et al (2012). Colorectal carcinoma: Pathologic aspects. J Gastrointest Oncol, 3, 153-73.
113 Franco R, Sanchez-Olea R, Reyes-Reyes EM, et al (2009). Environmental toxicity, oxidative stress and apoptosis: menage a trois. Mutat Res, 674, 3-22.   DOI
114 Moore KW, de Waal Malefyt R, Coffman RL, et al (2001). Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol, 19, 683-765.   DOI
115 Mates JM, Segura JA, Alonso FJ, et al (2008). Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis. Arch Toxicol, 82, 273-99.   DOI
116 McLellan EA, Bird RP (1988). Aberrant crypts: potential preneoplastic lesions in the murine colon. Cancer Res, 48, 6187-92.
117 Moghimi-Dehkordi B, Safaee A (2012). An overview of colorectal cancer survival rates and prognosis in Asia. World J Gastrointest Oncol, 4, 71-5.   DOI
118 Neergheen VS, Bahorun T, Taylor EW, et al (2010). Targeting specific cell signaling transduction pathways by dietary and medicinal phytochemicals in cancer chemoprevention. Toxicology, 278, 229-41.   DOI
119 Noda T, Iwakiri R, Fujimoto K, et al (2001). Induction of mild intracellular redox imbalance inhibits proliferation of CaCo- 2 cells. Faseb j, 15, 2131-9.   DOI
120 Norlida AO, Phang KS (2010). Histomorphology of aberrant crypt foci in colorectal carcinoma. Malays J Pathol, 32, 111-6.
121 Nunez F, Bravo S, Cruzat F, et al (2011). Wnt/beta-catenin signaling enhances cyclooxygenase-2 (COX2) transcriptional activity in gastric cancer cells. PLoS One, 6, e18562.   DOI
122 Guha P, Dey A, Sen R, et al (2011). Intracellular GSH depletion triggered mitochondrial Bax translocation to accomplish resveratrol-induced apoptosis in the U937 cell line. J Pharmacol Exp Ther, 336, 206-14.   DOI
123 Gambhir S, Vyas D, Hollis M, et al (2015). Nuclear factor kappa B role in inflammation associated gastrointestinal malignancies. World J Gastroenterol, 21, 3174-83.   DOI
124 Ge S, Sang T, Lu BR, et al (1999). Phylogeny of rice genomes with emphasis on origins of allotetraploid species. Proc Natl Acad Sci U S A, 96, 14400-5.   DOI
125 Greten FR, Eckmann L, Greten TF, et al (2004). IKKbeta links inflammation and tumorigenesis in a mouse model of colitisassociated cancer. Cell, 118, 285-96.   DOI
126 Haggar FA, Boushey RP (2009). Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors. Clin Colon Rectal Surg, 22, 191-7.   DOI
127 Halliwell B (2007). Dietary polyphenols: good, bad, or indifferent for your health?. Cardiovasc Res, 73, 341-7.   DOI
128 Okarter N, Liu RH (2010). Health benefits of whole grain phytochemicals. Crit Rev Food Sci Nutr, 50, 193-208.   DOI
129 Obrador E, Navarro J, Mompo J, et al (1997). Glutathione and the rate of cellular proliferation determine tumour cell sensitivity to tumour necrosis factor in vivo. Biochem J, 325, 183-9.   DOI
130 Odabasoglu F, Aslan A, Cakir A, et al (2004). Comparison of antioxidant activity and phenolic content of three lichen species. Phytother Res, 18, 938-41.   DOI