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http://dx.doi.org/10.22034/APJCP.2016.17.11.4985

Association of lnc-LAMC2-1:1 rs2147578 and CASC8 rs10505477 Polymorphisms with Risk of Childhood Acute Lymphoblastic Leukemia  

Hashemi, Mohammad (Cellular and Molecular Research Center, Zahedan University of Medical Sciences)
Bahari, Gholamreza (Cellular and Molecular Research Center, Zahedan University of Medical Sciences)
Naderi, Majid (Department of Pediatrics, School of Medicine, Zahedan University of Medical Sciences)
Bojd, Simin Sadeghi (Department of Pediatrics, School of Medicine, Zahedan University of Medical Sciences)
Taheri, Mohsen (Genetics of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.17, no.11, 2016 , pp. 4985-4989 More about this Journal
Abstract
Long non-coding RNAs (lncRNAs) are a novel class of non-protein coding RNAs that are involved in a wide variety of biological processes. There are limited data regarding the impact of lnc-LAMC2-1:1 rs2147578 as well as CASC8 rs10505477 T>C polymorphisms on cancer development. Here we examined for the first time whether rs2147578 and rs10505477 polymorphisms are associated with childhood acute lymphoblastic leukemia (ALL) in a total of 110 cases and 120 healthy controls. Genotyping was achieved by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The rs2147578 variant increased the risk of ALL in codominant (OR=4.33, 95%CI=2.00-9.37, p<0.0001, CG vs CC, and OR=5.81, 95%CI=2.30-14.69, p=0.0002, GG vs CC), dominant (OR=4.63, 95%CI=2.18-9.86, p<0.0001, CG+GG vs CC), overdominant (OR=1.74, 95%CI=1.02-2.97, p=0.0444, CG vs CC+GG) and allele (OR=1.91, 95%CI=1.32-2.77, p=0.0008, G vs C) inheritance models tested. No significant association was found between the CASC8 rs10505477 T>C variant and risk of childhood ALL. In conclusion, the present study revealed that the lnc-LAMC2-1:1 rs2147578 polymorphism may be a risk factor for developing childhood ALL. Further studies with larger sample sizes with different ethnicities are now required to confirm our findings.
Keywords
Long non-coding RNA; lnc-LAMC2-1:1; CASC8; acute lymphoblastic leukemia; Polymorphism;
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