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http://dx.doi.org/10.7314/APJCP.2015.16.18.8253

Plasma Soluble CD30 as a Possible Marker of Adult T-cell Leukemia in HTLV-1 Carriers: a Nested Case-Control Study  

Takemoto, Shigeki (Clinical Laboratory, National Hospital Organization Kumamoto Medical Center, Graduate School of Medical Sciences Kumamoto University)
Iwanaga, Masako (Department of Frontier Life Science, Nagasaki University Graduate School of Biomedical Sciences)
Sagara, Yasuko (Department of Quality, Japanese Red Cross Kyushu Block Blood Center)
Watanabe, Toshiki (Department of Medical Genome Science, Graduate School of Frontier Sciences, University of Tokyo)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.16, no.18, 2016 , pp. 8253-8258 More about this Journal
Abstract
Elevated levels of soluble CD30 (sCD30) are linked with various T-cell neoplasms. However, the relationship between sCD30 levels and the development of adult T-cell leukemia (ATL) in human T-cell leukemia virus type 1 (HTLV-1) carriers remains to be clarified. We here investigated whether plasma sCD30 is associated with risk of ATL in a nested case-control study within a cohort of HTLV-1 carriers. We compared sCD30 levels between 11 cases (i.e., HTLV-1 carriers who later progressed to ATL) and 22 age-, sex- and institution-matched control HTLV-1 carriers (i.e., those with no progression). The sCD30 concentration at baseline was significantly higher in cases than in controls (median 65.8, range 27.2-134.5 U/mL vs. median 22.2, range 8.4-63.1 U/mL, P=0.001). In the univariate logistic regression analysis, a higher sCD30 (${\geq}30.2U/mL$) was significantly associated with ATL development (odds ratio 7.88 and the 95% confidence intervals 1.35-45.8, P = 0.02). Among cases, sCD30 concentration tended to increase at the time of diagnosis of aggressive-type ATL, but the concentration was stable in those developing the smoldering-type. This suggests that sCD30 may serve as a predictive marker for the onset of aggressive-type ATL in HTLV-1 carriers.
Keywords
Adult T-cell leukemia (ATL); CD30; human T-cell leukemia virus type 1 (HTLV-1);
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