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http://dx.doi.org/10.7314/APJCP.2015.16.18.8067

Long Non-coding RNAs and Drug Resistance  

Pan, Jing-Jing (Clinical Laboratory, the First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University)
Xie, Xiao-Juan (Clinical Laboratory, the First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University)
Li, Xu (Translational Medicine Center, the First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University)
Chen, Wei (Clinical Laboratory, the First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.16, no.18, 2016 , pp. 8067-8073 More about this Journal
Abstract
Background: Long non-coding RNAs (lncRNAs) are emerging as key players in gene expression that govern cell developmental processes, and thus contributing to diseases, especially cancers. Many studies have suggested that aberrant expression of lncRNAs is responsible for drug resistance, a substantial obstacle for cancer therapy. Drug resistance not only results from individual variations in patients, but also from genetic and epigenetic differences in tumors. It is reported that drug resistance is tightly modulated by lncRNAs which change the stability and translation of mRNAs encoding factors involved in cell survival, proliferation, and drug metabolism. In this review, we summarize recent advances in research on lncRNAs associated with drug resistance and underlying molecular or cellular mechanisms, which may contribute helpful approaches for the development of new therapeutic strategies to overcome treatment failure.
Keywords
LncRNA; drug resistance; cancer;
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