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http://dx.doi.org/10.7314/APJCP.2015.16.9.3937

Metformin May Improve the Prognosis of Patients with Pancreatic Cancer  

Zhang, Jia-Wei (The Department of Oncology, Nanjing Medical University Affiliated Wuxi Second Hospital)
Sun, Qing (The Department of Oncology, Nanjing Medical University Affiliated Wuxi Second Hospital)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.16, no.9, 2015 , pp. 3937-3940 More about this Journal
Abstract
Background: Pancreatic cancer risk is increased in patients with type 2 diabetes, while being reduced by metformin treatment. However, it is unclear whether metformin could be associated with clinical outcomes of patients with pancreatic cancer and concurrent type 2 diabetes. Materials and Methods: A pooled analysis of 4 publications including 1,429 patients was performed to investigate the association of metformin and overall survival(OS) in patients with pancreatic cancer and concurrent type 2 diabetes. Results: A borderline significant relative survival benefit was found in metformin treated patients compared with non-metformin treated patients (hazard ratio 0.80; 95% CI: 0.62-1.03). Conclusions: These results suggest that further investigation is warranted of whether metformin may benefit the survival of patients with pancreatic cancer and concurrent type 2 diabetes.
Keywords
Pancreatic cancer; metformin; survival; prognosis;
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Times Cited By KSCI : 4  (Citation Analysis)
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