Browse > Article
http://dx.doi.org/10.7314/APJCP.2015.16.9.3857

Correlation between Serum Carcinoembryonic Antigen Level and Histologic Subtype in Resected Lung Adenocarcinoma  

Tomita, Masaki (Department of Cardiovascular, Thoracic and General Surgery, Faculty of Medicine, University of Miyazaki)
Ayabe, Takanori (Department of Cardiovascular, Thoracic and General Surgery, Faculty of Medicine, University of Miyazaki)
Nakamura, Eiichi Chosa Kunihide (Department of Cardiovascular, Thoracic and General Surgery, Faculty of Medicine, University of Miyazaki)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.16, no.9, 2015 , pp. 3857-3860 More about this Journal
Abstract
Background: Recent studies revealed a relationship between ground-glass opacity (GGO) ratio on computed tomography (CT) and serum carcinoembryonic antigen (CEA) level in lung adenocarcinoma. Since an association between lepidic histologic pattern and GGO is well accepted, we investigated the link between histologic subtype and serum CEA level in resected lung adenocarcinoma. Materials and Methods: One hundred and eighty-one consecutive patients with resected lung adenocarcinoma were studied retrospectively. The histologic subtype was subdivided into 2 groups: lepidic dominant histologic subtype, including adenocarcinoma in situ, minimally invasive adenocarcinoma and lepidic predominant invasive adenocarcinoma versus other subtypes. Results: The 5-year survival of patients with s high serum CEA level was significantly more unfavorable than that with normal levels. Similarly, there was also a relationship between the patient survival and histologic subtype, with favorable survival found in patients with the lepidic dominant histologic subtype. There was a significant relationship between serum CEA level and lepidic dominant histologic subtype overall and in p-stage I patients. Conclusions: Lung adenocarcinomas with non-lepidic dominant histologic subtype are associated with high serum CEA levels.
Keywords
CEA; lepidic histologic subtype; GGO; lung adenocarcinoma; prognosis;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
연도 인용수 순위
1 Ambrosini-Spaltro A, Ruiu A, Seebacher C, et al (2014). Impact of the IASLC/ATS/ERS classification in pN0 pulmonary adenocarcinomas: a study with radiological-pathological comparisons and survival analyses. Pathol Res Pract, 210, 40-6.   DOI
2 Araki K, Kidokoro Y, Hosoya K, et al (2014). Excellent prognosis of lepidic-predominant lung adenocarcinoma: low incidence of lymphatic vessel invasion as a key factor. Anticancer Res, 34, 3153-6.
3 Fukuda I, Yamakado M, Kiyose H (1998). Influence of smoking on serum carcinoembryonic antigen levels in subjects who underwent multiphasic health testing and services. J Med Syst, 22, 89-93.   DOI
4 Hamada Y, Yamamura M, Hioki K, et al (1985). Immunohistochemical study of carcinoembryonic antigen in patients with colorectal cancer. Correlation with plasma carcinoembryonic antigen levels. Cancer, 55, 136-41.   DOI
5 Kadota K, Villena-Vargas J, Yoshizawa A, et al (2014). Prognostic significance of adenocarcinoma in situ, minimally invasive adenocarcinoma, and nonmucinous lepidic predominant invasive adenocarcinoma of the lung in patients with stage I disease. Am J Surg Pathol, 38, 448-60.   DOI
6 Kodama K, Higashiyama M, Yokouchi H, et al (2001). Prognostic value of ground-glass opacity found in small lung adenocarcinoma on high-resolution CT scanning. Lung Cancer, 33, 17-25.   DOI
7 Matsuguma H, Nakahara R, Igarashi S, et al (2008). Pathologic stage I non-small cell lung cancer with high levels of preoperative serum carcinoembryonic antigen: clinicopathologic characteristics and prognosis. J Thorac Cardiovasc Surg, 135, 44-9.   DOI
8 Miao XH, Yao YW, Yuan DM, et al (2012). Prognostic value of the ratio of ground glass opacity on computed tomography in small lung adenocarcinoma: A meta-analysis. J Thorac Dis, 4, 265-71.
9 Okada M, Nishio W, Sakamoto T, et al (2004). Prognostic significance of perioperative serum carcinoembryonic antigen in non-small cell lung cancer: analysis of 1,000 consecutive resections for clinical stage I disease. Ann Thorac Surg, 78, 216-21.   DOI
10 Okada M, Tauchi S, Iwanaga K, et al (2007). Associations among bronchioloalveolar carcinoma components, positron emission tomographic and computed tomographic findings, and malignant behavior in small lung adenocarcinomas. J Thorac Cardiovasc Surg, 133, 1448-54.   DOI
11 Qin HF, Qu LL, Liu H, et al (2013). Serum CEA level change and its significance before and after Gefitinib therapy on patients with advanced non-small cell lung cancer. Asian Pac J Cancer Prev, 14, 4205-8.   DOI   ScienceOn
12 Sawabata N, Maeda H, Yokota S, et al (2004). Postoperative serum carcinoembryonic antigen levels in patients with pathologic stage IA nonsmall cell lung carcinoma: subnormal levels as an indicator of favorable prognosis. Cancer, 101, 803-9.   DOI
13 Tomita M, Matsuzaki Y, Edagawa M, et al (2004). Prognostic significance of preoperative serum carcinoembryonic antigen level in lung adenocarcinoma but not squamous cell carcinoma. Ann Thorac Cardiovasc Surg, 10, 76-80.
14 Shimizu K, Yamada K, Saito H, et al (2005). Surgically curable peripheral lung carcinoma: correlation of thin-section CT findings with histologic prognostic factors and survival. Chest, 127, 871-8.   DOI
15 Takamochi K, Nagai K, Suzuki K, et al (2000). Clinical predictors of N2 disease in non-small cell lung cancer. Chest, 117, 1577-82.   DOI
16 Tomita M, Ayabe T, Chosa E, et al (2013). Is there a relationship between serum carcinoembryonic antigen level and epidermal growth factor receptor mutations in resected lung adenocarcinomas? Ann Cancer Res Ther, 21, 31-5.   DOI
17 Tomita M, Matsuzaki Y, Shimizu T, et al (2006). Relationship between serum carcinoembryonic antigen level and T status in non-small cell lung cancer. Anticancer Res, 26, 3845-8.
18 Travis WD, Brambilla E, Noguchi M, et al (2011). International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol, 6, 244-85.   DOI
19 Wang B, He YJ, Tian YX, et al (2014). Clinical utility of haptoglobin in combination with CEA, NSE and CYFRA21-1 for diagnosis of lung cancer. Asian Pac J Cancer Prev, 15, 9611-4.   DOI
20 Wang WJ, Tao Z, Gu W, et al (2013). Clinical observations on the association between diagnosis of lung cancer and serum tumor markers in combination. Asian Pac J Cancer Prev, 14, 4369-71.   DOI   ScienceOn
21 Yatabe Y, Hida T, Horio Y, et al (2006). A rapid, sensitive assay to detect EGFR mutation in small biopsy specimens from lung cancer. J Mol Diagn, 8, 335-41.   DOI
22 Wang WT, Li Y, Ma J, et al (2014). Serum carcinoembryonic antigen levels before initial treatment are associated with EGFR mutations and EML4- ALK fusion gene in lung adenocarcinoma patients. Asian Pac J Cancer Prev, 15, 3927-32.   DOI
23 Weichert W, Warth A (2014). Early lung cancer with lepidic pattern: adenocarcinoma in situ, minimally invasive adenocarcinoma, and lepidic predominant adenocarcinoma. Curr Opin Pulm Med, 20, 309-16.   DOI
24 Yamazaki M, Ishikawa H, Kunii R, et al (2014). Relationship between CT features and high preoperative serum carcinoembryonic antigen levels in early-stage lung adenocarcinoma. Clin Radiol, 69, 559-66.   DOI
25 Ye B, Cheng M, Ge XX, et al (2014). Factors that predict lymph node status in clinical stage T1aN0M0 lung adenocarcinomas. World J Surg Oncol, 12, 42.   DOI
26 Zamcheck N, Doos WG, Prudente R, et al (1975). Prognostic factors in colon carcinoma: correlation of serum carcinoembryonic antigen level and tumor histopathology. Hum Pathol, 6, 31-45.   DOI