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http://dx.doi.org/10.7314/APJCP.2015.16.7.2665

Tumor-derived CD4+CD25+ Tregs Inhibit the Maturation and Antigen-Presenting Function of Dendritic Cells  

Du, Yong (Department of Pediatrics, First Affiliated Hospital of Wenzhou Medical University)
Chen, Xin (Department of Gastroenterology and Hepatology, First Affiliated Hospital of Wenzhou Medical University)
Lin, Xiu-Qing (Department of Gastroenterology and Hepatology, First Affiliated Hospital of Wenzhou Medical University)
Wu, Wei (Department of Gastroenterology and Hepatology, First Affiliated Hospital of Wenzhou Medical University)
Huang, Zhi-Ming (Department of Gastroenterology and Hepatology, First Affiliated Hospital of Wenzhou Medical University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.16, no.7, 2015 , pp. 2665-2669 More about this Journal
Abstract
CD4+CD25+regulatory T cells (Tregs) play a key role in regulation of immnue response and maintenance of self-tolerance. Studies have found Tregs could suppress tumor-specific T cell-mediated immune response and promote cancer progression. Depletion of Tregs can enhance antitumor immunity. Dendritic cells (DCs) are professional antigen-presenting cells and capable of activating antigen-specific immune responses, which make them ideal candidate for cancer immunotherapy. Now various DC vaccines are considered as effective treatment for cancers. The aim of this study was to evaluate variation of Tregs in BALB/C mice with hepatocellular carcinoma and investigate the interaction between tumor-derived Tregs, effector T cells (Teff) and splenic DCs. We found the percentages of Tregs/CD4+ in the peripheral blood of tumor-bearing mice were higher than in normal mice. Tumor-derived Tregs diminished the up-regulation of costimulatory molecule expression on splenic DCs, even in the presence of Teff cells and simultaneously inhibited IL-12 and $TNF-{\alpha}$ secretion by DCs.
Keywords
CD4+CD25+regulatory T cell; dendritic cell; costimulatory molecule; immunoregulation;
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1 Ahmed Ali HA, Di J, Mei W, et al (2014). Antitumor activity of lentivirus-mediated interleukin-12 gene modified dendritic cells in human lung cancer in vitro. Asian Pac J Cancer Prev, 15, 611-6.   DOI   ScienceOn
2 Auray G, Facci MR, van Kessel J, et al (2010). Differential activation and maturation of two porcine DC population follow TLR ligand stimulation. Mol Immunol, 47, 2103-11.   DOI
3 Bonifaz L, Bonnyay D, Mahnke K, et al (2002). Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class Iproducts and peripheral CD8+ T cell tolerance. J Exp Med, 196, 1627-38.   DOI
4 Cabrera R, Ararat M, Eksioglu EA, et al (2010). Influence of serum and soluble CD25 (sCD25) on regulatory and effector T cell function in hepatocellular carcinoma. Scand J Immunol, 72, 293-301.   DOI
5 Corthay A (2009). How do regulatory T cells work? Scand J Immunol, 70, 326-36.   DOI
6 Forner A, Llovet JM, Bruix J (2012). Hepatocellular carcinoma. Lancet, 379, 1245-55.   DOI
7 Fu T, Zhang P, Feng L, et al (2011). Accelerated acute allograft rejection accompanied by enhanced T-cell proliferation and attenuated treg function in RBP-J deficient mice. Mol Immunol, 48, 751-9.   DOI
8 Herman S, Krenbek D, Klimas M, et al (2012). Regulatory T cells form stable and long-lasting cell cluster with myeloid dendritic cells (DC). Int Immunol, 24, 417-26.   DOI
9 Hu JL, Yang Z, Tang JR, et al (2013). Effects of gastric cancer cells on the differentiation of Treg cells. Asian Pac J Cancer Prev, 14, 4607-10   DOI   ScienceOn
10 Hu YX, Li M, Jia XH, et al (2013). HPV16 CTL epitope peptide-activated dendritic cell and natural killer co-culture for therapy of cervical cancer in an animal model. Asian Pac J Cancer Prev, 14, 7335-8   DOI   ScienceOn
11 Jemal A, Bray F, Center MM, et al (2011). Global cancer statistices. CA Cancer J Clin, 61, 69-90.   DOI
12 Kohl J, Wills-Karp M (2007). Complement regulates inhalation tolerance at the dendritic cell/T cell interface. Mol Immunol, 44, 44-56.   DOI
13 Liu Z, Kim JH, Falo LD Jr, et al (2009). Tumor regulatory T cells potently abrogate antitumor immunity. J Immunol, 182, 6160-7.   DOI
14 Onishi Y, Fehervari Z, Yamaguchi T, et al (2008). Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. PNAS, 105, 10113-8.   DOI
15 Ramanathan P, Ganeshrajah S, Kamalalayam R, et al (2014). Development and clinical evaluation of dendritic cell vaccines for HPV related cervical cancer- a feasibility study. Asian Pac J Cancer Prev, 15, 5909-16   DOI
16 Shen Z, Zhou S, Wang Y, et al (2010). Higher intratumoral infiltrated Foxp3+ Treg numbers and Foxp3+/CD8+ ratio are associated with adverse prognosis in resectable gastric cancer. J Cancer Res Clin Oncol, 136, 1585-95.   DOI
17 Unitt E, Rushbrook SM, Marshall A, et al (2005). Compromised lymphocytes infiltrate hepatocellular carcinoma: the role of T-regulatory cells. Hepatol, 41, 722-30.   DOI
18 Wan WJ, Tao Z, Gu W, et al (2013). Variation of blood T lymphocyte subgroups in patients with non-small cell lung cancer. Asian Pac J Cancer Prev, 14, 4671-3.   DOI   ScienceOn
19 Zhan HL, Gao X, Zhou XF, et al (2012). Presence of tumour-infiltrating foxp3+ lymphocytes correlates with immature tumour angiogenesis in renal cell carcinomas. Asian Pac J Cancer Prev, 13, 867-72.   DOI