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http://dx.doi.org/10.7314/APJCP.2015.16.7.2653

Nasopharyngeal Carcinoma Incidence in North Tunisia: Negative Trends in Adults but not Adolescents, 1994-2006  

Wided, Ben Ayoub Hizem (Department of Epidemiology and Biostatistics, Salah Azaiez Institute of Oncology Cancer Registry North of Tunisia)
Hamouda, Boussen (Medical Oncology Department, Abderrahmen Mami Hospital)
Hamadi, Hsairi (National Institute of Public Health)
Mansour, Ben Abdallah (Department of Epidemiology and Biostatistics, Salah Azaiez Institute of Oncology Cancer Registry North of Tunisia)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.16, no.7, 2015 , pp. 2653-2657 More about this Journal
Abstract
Nasopharyngeal carcinoma (NPC) is the second most common neoplasm of head and neck in Tunisia. The distribution is bimodal with a first period occurrence between 15 and 20 years old and a second peak at around 50 years of age. Undifferentiated carcinoma of nasopharynx type III (UCNT) is the predominant histological type (93.4%). Data of cancer registry of North Tunisia confirmed that it is an intermediate risk area for NPC with overall ASRs of 3.6 and 1.6/100,000 respectively in males and females. This study aimed to present the evolution of incidence rate of nasopharyngeal carcinoma over a period of 12 years (1994-2006). Data of cancer registry of North Tunisia (NTCR), covering half of the Tunisian population, were used to determine evolution of NPC incidence, calculated by 5 year periods. The estimated annual percentage change (EAPC) was used as an estimate of the trend. To best summarize the behavior or the data trend across years, we used a join-point regression program. Between 1994 and 2006, we observed negative annual average change of standardized incidence in men and women (-3.3%and -2.7%) also for the standardized incidences which showed a rather important decline (26.4% in males and 22.3% in females). The truncated age standardized incidence rate of NPC in adults aged of 30 years old and more (N= 1209) decreased by -0.4% per year from 1994 to 2006 over time in north Tunisia dropping from 6.09 to 4.14 person-years. However, the rate was relatively stable during this period among youths aged 0-29 years (N= 233) in both sexes. NPC demonstrated a favorable evolution from 1994-2006 probably due to a improvement in socioeconomic conditions.
Keywords
Nasopharyngeal carcinoma; incidence; trends; North Tunisia;
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