[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.7314/APJCP.2015.16.5.1997

P53 Polymorphism at Codon 72 is Associated with Keratocystic Odontogenic Tumors in the Thai Population

Yanatatsaneejit, Pattamawadee (Human Genetics Research Group, Department of Botany, Faculty of Science)
Boonsrang, Ajaree (Human Genetics Research Group, Department of Botany, Faculty of Science)
Mutirangura, Apiwat (Center of Excellence in Molecular Genetics of Cancer and Human Diseases, Department of Anatomy, Faculty of Medicine, Chulalongkorn University)
Patel, Vyomesh (Cancer Research Initiatives Foundation (CARIF), 2nd Floor Outpatient Centre, Sime Darby Medical Centre)
Kitkumthorn, Nakarin (Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Mahidol University)

Publication Information

Asian Pacific Journal of Cancer Prevention / v.16, no.5, 2015 , pp. 1997-2001 More about this Journal

Abstract

Objective: To clarify the association between the p53 polymorphism at codon 72 and susceptibility to the sporadic keratocystic odontogenic tumor (KCOT). Design: One hundred KCOTs and 160 match-group healthy controls were genotyped to ascertain the frequency of the p53 codon 72 polymorphism using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), confirmed by direct sequencing. Results: The frequencies of the Pro/Pro, Arg/Pro, and Arg/Arg genotypes were 23.8%, 49.4%, and 26.9%, respectively, in the controls, while the KCOT cohort demonstrated 43.0%, 39.0%, and 18.0%, respectively. Further analysis suggested that p53 Pro could be a KCOT-susceptible allele (OR (95%CI)=1.77 (1.22 to 2.59), p=0.0024), with a sex-adjusted OR (95%CI) of 1.71 (1.17-2.50), p=0.0046. Moreover, the results indicated that p53 codon 72 Pro homozygous was associated with a two-fold risk of developing KCOT (adjusted OR (95%CI) =2.17(1.23-3.84), p=0.0062). Conclusions: The C/C genotype of P53 gene codon 72 increases the risk of developing sporadic KCOT and may be a useful tool for screening and diagnostic purposes.

Keywords

Keratocystic odontogenic tumor; P53; polymorphism; risk;

Citations & Related Records

Times Cited By KSCI : 5 (Citation Analysis)

Reference
Cited By KSCI

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