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http://dx.doi.org/10.7314/APJCP.2015.16.5.1935

Lack of Participation of the GSTM1 Polymorphism in Cervical Cancer Development in Northeast Thailand  

Natphopsuk, Sitakan (Department of Physiology, Khon Kaen University)
Settheetham-Ishida, Wannapa (Department of Physiology, Khon Kaen University)
Settheetham, Dariwan (Department of Environmental Health, Khon Kaen University)
Ishida, Takafumi (Department of Biological Sciences, Graduate School of Science, The University of Tokyo)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.16, no.5, 2015 , pp. 1935-1937 More about this Journal
Abstract
The potential association between the GSTM1 deletion polymorphism and risk of cervical cancer was investigated in Northeastern Thailand. DNA was extracted from buffy coat specimens of 198 patients with squamous cell carcinoma of the cervix and 198 age-matched healthy controls. Genotyping of the GSTM1 was conducted by using two PCR methods, a short- and a long-PCR. Distribution of the GSTM1 genotypes in between the cases and the controls was not significantly different (p>0.5 by ${\chi}^2$ test). The results suggest that the GSTM1 deletion polymorphism is not a risk factor for squamous cell carcinoma of the cervix in the northeast Thai women.
Keywords
Cervical cancer; GSTM1 genotype; genetic susceptibility; Northeast Thailand;
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