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http://dx.doi.org/10.7314/APJCP.2015.16.2.495

Updated Assessment of the Association of the XRCC1 Arg399Gln Polymorphism with Lung Cancer Risk in the Chinese Population  

Yang, Hai-Yan (Department of Epidemiology, School of Public Health, Zhengzhou University)
Yang, Si-Yu (Department of Epidemiology, School of Public Health, Zhengzhou University)
Shao, Fu-Ye (Department of Epidemiology, School of Public Health, Zhengzhou University)
Wang, Hai-Yu (Department of Toxicology, Henan Center for Disease Control and Prevention)
Wang, Ya-Dong (Department of Toxicology, Henan Center for Disease Control and Prevention)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.16, no.2, 2015 , pp. 495-500 More about this Journal
Abstract
Background: Published studies have reported relationships between X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphism and lung cancer risk in Chinese population. However, the epidemiological results remained controversial. The objective of this study was to clarify the association of XRCC1 Arg399Gln polymorphism with lung cancer risk in the Chinese population. Materials and Methods: Systematic searches were performed through the database of Medline/Pubmed, Web of Science, Embase, CNKI and WanFang Medical Online. Odds ratios (ORs) with 95% confidence interval (95%CI) were calculated to estimate the strength of the association. Results: Overall, we observed an increased lung cancer risk among subjects carrying XRCC1 codon 399 Gln/Gln genotype (OR=1.36, 95%CI: 1.09-1.71) in the Chinese population on the basis of 19 studies with 5,416 cases and 5,782 controls. We did not observe any association between XRCC1 codon 399 Arg/Gln and Arg/Gln+Gln/Gln polymorphisms and lung cancer risk (OR=1.00, 95%CI: 0.92-1.08 and OR=1.05, 95%CI: 0.97-1.13, respectively). Limiting the analysis to studies with controls in agreement with Hardy-Weinberg equilibrium (HWE), we observed an increased lung cancer risk among subjects carrying XRCC1 codon 399 Gln/Gln genotype (OR=1.18, 95%CI: 1.01-1.38). When stratified by source of control, we observed an increased lung cancer risk among subjects carrying XRCC1 codon 399 Arg/Gln+Gln/Gln genotype on the basis of hospitalized patient-based controls (OR=1.21, 95%CI: 1.04-1.42) and among subjects carrying XRCC1 codon 399 Gln/Gln genotype on the basis of healthy subject-based controls (OR=1.22, 95%CI: 1.04-1.43). Conclusions: Our findings indicated that certain XRCC1 Arg399Gln variants might affect the susceptibility of lung cancer in Chinese population. Larger sample size studies are required to confirm our findings.
Keywords
Lung cancer; risk; XRCC1 Arg399Gln; polymorphism; meta-analysis; Chinese;
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1 Almeida KH, Sobol RW (2007). A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification. DNA Repair (Amst), 6, 695-711.   DOI
2 Begg CB, Mazumdar M (1994). Operating characteristics of a rank correlation test for publication bias. Biometrics, 50, 1088-101.   DOI
3 Chan EC, Lam SY, Fu KH, et al (2005). Polymorphisms of the GSTM1, GSTP1, MPO, XRCC1, and NQO1 genes in Chinese patients with non-small cell lung cancers: relationship with aberrant promoter methylation of the CDKN2A and RARB genes. Cancer Genet Cytogenet, 162, 10-20.   DOI   ScienceOn
4 Chen S, Tang D, Xue K, et al (2002). DNA repair gene XRCC1 and XPD polymorphisms and risk of lung cancer in a Chinese population. Carcinogenesis, 23, 1321-5.   DOI
5 Dai L, Wang K, Zhang J, et al (2009). XRCC1 gene polymorphisms and esophageal squamous cell carcinoma risk in Chinese population: A meta-analysis of case-control studies. Int J Cancer, 125, 1102-9.   DOI
6 DerSimonian R, Laird N (1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177-88.   DOI
7 Du Y, Chu DJ, Shi JM, et al (2012). The relationship between lung cancer and genetic polymorphism of XRCC1. J Clin Intern Med, 29, 346-8.
8 Du Y, He Y, Mei Z, et al (2014). Association between genetic polymorphisms in XPD and XRCC1 genes and risks of non-small cell lung cancer in East Chinese Han population. Clin Respir J.
9 Duan WH, Zhu ZY, Liu JG, et al (2012). XRCC1 Arg399Gln gene polymorphism and hepatocellular carcinoma risk in the Chinese Han population: a meta-analysis. Asian Pac J Cancer Prev, 13, 3601-4.   DOI   ScienceOn
10 Egger M, Davey Smith G, Schneider M, et al (1997). Bias in meta-analysis detected by a simple, graphical test. Bmj, 315, 629-34.   DOI
11 Guo S, Li X, Gao M, et al (2013). The relationship between XRCC1 and XRCC3 gene polymorphisms and lung cancer risk in northeastern Chinese. PLoS One, 8, 56213.   DOI
12 Hao B, Miao X, Li Y, et al (2006). A novel T-77C polymorphism in DNA repair gene XRCC1 contributes to diminished promoter activity and increased risk of non-small cell lung cancer. Oncogene, 25, 3613-20.   DOI
13 Kubota Y, Nash RA, Klungland A, et al (1996). Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein. EMBO J, 15, 6662-70.
14 Hu Z, Ma H, Lu D, et al (2005). A promoter polymorphism (-77T>C) of DNA repair gene XRCC1 is associated with risk of lung cancer in relation to tobacco smoking. Pharmacogenet Genomics, 15, 457-63.   DOI
15 Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90.   DOI
16 Kazma R, Babron MC, Gaborieau V, et al (2012). Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium. Carcinogenesis, 33, 1059-64.   DOI
17 Li J, Mu L, Wei G, et al (2005a). Relationship between polymorphisms of DNA repair gene XRCC1 and susceptibility to lung cancer. China Oncology, 15, 335-8.
18 Li M, Yin Z, Cui Z, et al (2005b). Association of genetic polymorphism in DNA repair gene XRCC1 with risk of lung adenocarcinoma in nonsmoking women. Chinese J Lung Cancer, 8, 431-4.
19 Li M, Yin Z, Guan P, et al (2008). XRCC1 polymorphisms, cooking oil fume and lung cancer in Chinese women nonsmokers. Lung Cancer, 62, 145-51.   DOI
20 Li MC, Cui ZS, He QC, et al (2005c). Association of genetic polymorphism in the DNA repair gene XRCC1 with susceptibility to lung cancer in non-smoking women. Chin J Oncol, 27, 713-6.
21 Li Y, Huang Y, Cao YS, et al (2013). Assessment of the association between XRCC1 Arg399Gln polymorphism and lung cancer in Chinese. Tumour Biol, 34, 3681-5.   DOI   ScienceOn
22 Qian B, Zhang H, Zhang L, et al (2011). Association of genetic polymorphisms in DNA repair pathway genes with nonsmall cell lung cancer risk. Lung Cancer, 73, 138-46.   DOI
23 Li Z, Guan W, Li MX, et al (2011). Genetic polymorphism of DNA base-excision repair genes (APE1, OGG1 and XRCC1) and their correlation with risk of lung cancer in a Chinese population. Arch Med Res, 42, 226-34.   DOI   ScienceOn
24 Ouyang FD, Yang FL, Chen HC, et al (2013). Polymorphisms of DNA repair genes XPD, XRCC1, and OGG1, and lung adenocarcinoma susceptibility in Chinese population. Tumour Biol, 34, 2843-8.   DOI   ScienceOn
25 Parkin DM, Bray F, Ferlay J, et al (2005). Global cancer statistics, 2002. CA Cancer J Clin, 55, 74-108.   DOI
26 Ratnasinghe D, Yao SX, Tangrea JA, et al (2001). Polymorphisms of the DNA repair gene XRCC1 and lung cancer risk. Cancer Epidemiol Biomarkers Prev, 10, 119-23.
27 Salanti G, Amountza G, Ntzani EE, et al (2005). Hardy-Weinberg equilibrium in genetic association studies: an empirical evaluation of reporting, deviations, and power. Eur J Hum Genet, 13, 840-8.   DOI
28 Shen M, Berndt SI, Rothman N, et al (2005). Polymorphisms in the DNA base excision repair genes APEX1 and XRCC1 and lung cancer risk in Xuan Wei, China. Anticancer Res, 25, 537-42.
29 Shen MR, Jones IM, Mohrenweiser H (1998). Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans. Cancer Res, 58, 604-8.
30 Song Y, Yin L, Pu Y, et al (2004). Relationship between Polymorphisms of DNA Repair Gene XRCC1 and Susceptibility to Lung Cancer in Nanjing Population. Journal of Labour Medicine, 21, 18-21.
31 Wang L, Lin Y, Qi CC, et al (2014). Association of the XRCC1 c.1178G>A genetic polymorphism with lung cancer risk in Chinese. Asian Pac J Cancer Prev, 15, 4095-9.   DOI
32 Su J, Niu R, Liu L, et al (2008). Regression analysis between polymorphisms of DNA repair gene XRCC1 and susceptibility to lung cancer of nonsmoking women. J Zhengzhou University Medical Sciences, 43, 234-8.
33 Tian Z, Li YL, Liu JG (2013). XRCC1 Arg399Gln polymorphism contributes to increased risk of colorectal cancer in Chinese population. Mol Biol Rep, 40, 4147-51.   DOI
34 Vidal AE, Boiteux S, Hickson ID, et al (2001). XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions. EMBO J, 20, 6530-9.   DOI
35 Wang N, Wu Y, Zhou X (2012a). Association between genetic polymorphism of metabolizing enzymes and DNA repairing enzymes and the susceptibility of lung cancer in Henan population. Wei Sheng Yan Jiu, 41, 251-6.
36 Wang N, Wu YJ, Zhou XL, et al (2012b). The polymorphisms of XRCC1 gene and susceptibility to pulmonary cancer. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, 30, 41-4.
37 Yin J, Vogel U, Ma Y, et al (2007). The DNA repair gene XRCC1 and genetic susceptibility of lung cancer in a northeastern Chinese population. Lung Cancer, 56, 153-60.   DOI
38 Yin J, Vogel U, Ma Y, et al (2009). Association of DNA repair gene XRCC1 and lung cancer susceptibility among nonsmoking Chinese women. Cancer Genet Cytogenet, 188, 26-31.   DOI   ScienceOn
39 Yu H, Zeng X, Chou X, et al (2006). Polymorphism in the DNA repair gene XRCC1 and susceptibility to human lung cancer. J Guangxi Medical University, 23, 355-8.
40 Yu H, Zhao H, Wang LE, et al (2011). An analysis of single nucleotide polymorphisms of 125 DNA repair genes in the Texas genome-wide association study of lung cancer with a replication for the XRCC4 SNPs. DNA Repair, 10, 398-407.   DOI   ScienceOn
41 Zhang W, Wu Y, Wu Y (2005a). Study on polymorphism of XRCC1 and susceptibility to lung cancer. China Public Health, 5, 561-3.
42 Zhang X, Miao X, Liang G, et al (2005b). Polymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer. Cancer Res, 65, 722-6.
43 Zhang ZY, Xuan Y, Jin XY, et al (2013). Meta-analysis demonstrates association of XRCC1 genetic polymorphism Arg399Gln with esophageal cancer risk in the Chinese population. Genet Mol Res, 12, 2567-77.   DOI
44 Zheng H, Wang Z, Shi X (2009). XRCC1 polymorphisms and lung cancer risk in Chinese populations: a meta-analysis. Lung Cancer, 65, 268-73.   DOI
45 Zhong D, Li G, Long J, et al (2012). The hOGG1Ser326Cys polymorphism and increased lung cancer susceptibility in Caucasians: an updated meta-analysis. Sci Rep, 2, 548.