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http://dx.doi.org/10.7314/APJCP.2015.16.2.485

Manganese Superoxide Dismutase (MnSOD Val-9Ala) Gene Polymorphism and Susceptibility to Gastric Cancer  

Moradi, Mohammad-Taher (Medical Biology Research Center, Kermanshah University of Medical Sciences)
Yari, Kheirollah (Medical Biology Research Center, Kermanshah University of Medical Sciences)
Rahimi, Zohreh (Medical Biology Research Center, Kermanshah University of Medical Sciences)
Kazemi, Elham (Medical Biology Research Center, Kermanshah University of Medical Sciences)
Shahbazi, Mehrdad (Islamic Azad University of Ahar)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.16, no.2, 2015 , pp. 485-488 More about this Journal
Abstract
Background: Oxidative stress caused by the generation of reactive oxygen species plays an important role in human carcinogenesis. Manganese superoxide dismutase (MnSOD) Val-9Ala in the mitochondrial target sequence is the best known polymorphism of this enzyme. The purpose of the current research was to assess the association of MnSOD Val-9Ala genotypes with the risk of gastric cancer. Materials and Methods: This case-control study covered 54 gastric cancer patients compared to 100 cancer free subjects as controls. Extraction of DNA was performed on bioptic samples and genotypes were identified with a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: The frequencies of MnSOD Ala/Ala, Ala/Val and Val/Val genotypes in healthy individuals were 24.3, 66.7 and 9%, respectively. However, in gastric cancer patients, Ala/Ala, Ala/Val and Val/Val were observed in 24.0, 48.0 and 28.0% (p=0.01). In patients the frequency of MnSOD Val allele was higher (52%) compared to that in controls (42%). Conclusions: The results of this study show a positive association between MnSOD Val-9Ala gene polymorphism and risk of gastric cancer disease in Iranian population.
Keywords
MnSOD Val-9Ala; gastric cancer; genetic polymorphism; Iran;
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