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http://dx.doi.org/10.7314/APJCP.2015.16.17.7905

MicroRNA-124 rs531564 Polymorphism and Cancer Risk: A Meta-analysis  

Li, Wen-Jing (Medical Research Center, the Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People's Hospital)
Wang, Yong (Medical Research Center, the Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People's Hospital)
Gong, Yu (Medical Research Center, the Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People's Hospital)
Tu, Chao (Medical Research Center, the Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People's Hospital)
Feng, Tong-Bao (Medical Research Center, the Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People's Hospital)
Qi, Chun-Jian (Medical Research Center, the Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People's Hospital)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.16, no.17, 2015 , pp. 7905-7909 More about this Journal
Abstract
Several studies reported there was a polymorphism (rs531564 C > G) in miR-124 gene. To investigate the MiR-124 rs531564 polymorphism and cancer risk. We conducted a literature search of the Medline, Embase and Wangfang Medicine databases to identify all relevant studies for this meta-analysis. We determined that the miR-124 rs531564 polymorphism was significantly associated with decreased risks of cancers in the allelic model (G vs C, OR=0.71, 95% CI=0.53-0.94, P=0.02), homozygote model (GG vs CC, OR=0.42, 95% CI=0.26-0.66, P=0.0002), dominant model (GG/GC vs CC, OR=0.71, 95% CI=0.51-0.98, P=0.04) and recessive model (GG vs GC/CC, OR=0.43, 95% CI=0.27-0.69, P=0.0004). In an analysis stratified by cervical cancer group, significant associations were observed in the allelic model (G vs C, OR=0.46, 95% CI=0.32-0.66, P<0.0001), and dominant model (GG/GC vs CC, OR=0.45, 95% CI=0.3-0.66, P<0.0001). Subgroup analysis also revealed a decreased risk for esophageal squamous cell carcinoma in the homozygote model (GG vs CC, OR=0.45, 95% CI=0.27-0.75, P=0.002) and recessive model (GG vs GC/CC, OR=0.46, 95% CI=0.28-0.75, P=0.002). This meta-analysis suggests that the miR-124 rs531564 C > G polymorphism is an important risk factor for cancers among the Chinese population.
Keywords
miR-124; rs531564; polymorphism; cancer risk; meta-analysis;
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