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http://dx.doi.org/10.7314/APJCP.2015.16.13.5187

β-Catenin Alterations in Squamous Cell Carcinoma of the Lip  

Barakat, Charif (Department of Oral Histology and Pathology, Faculty of Dentistry, University of Damascus)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.16, no.13, 2015 , pp. 5187-5190 More about this Journal
Abstract
This study aimed to investigate the correlation between ${\beta}$-catenin immunoexpression and histopathological grades of lower lip squamous cell carcinoma (LSCC). $\beta$-Catenin abnormal expression was found in 29% of the squamous cells of well differentiated LSCC, 63% of moderately differentiated and 86% of poorly differentiated, and therefor was significantly associated with histological grade (p=0.000). Nuclear $\beta$-catenin expression appeared in 5% of the cells and was also correlated with the histological grades (p=0.000). In 14.7% of the cells it was localized in the cytoplasm, again correlating with histology (p=0.002). According to this study the expression of $\beta$-catenin is an independent prognostic factor for histological grade and to the tumor differentiation. This appears to reflect a structural association and the role of $\beta$-catenin in tumor progression.
Keywords
Lip squamous cell carcinoma; $\beta$-catenin; immunoexpression;
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