Browse > Article
http://dx.doi.org/10.7314/APJCP.2015.16.12.4833

Immunosignature: Serum Antibody Profiling for Cancer Diagnostics  

Chapoval, Andrei I (Russian-American Anti-Cancer Center, Institute of Biomedicine, Altai State University)
Legutki, J Bart (Center for Innovations in Medicine, Biodesign Institute, Arizona State University)
Stafford, Philip (Center for Innovations in Medicine, Biodesign Institute, Arizona State University)
Trebukhov, Andrey V (Russian-American Anti-Cancer Center, Institute of Biomedicine, Altai State University)
Johnston, Stephen A (Center for Innovations in Medicine, Biodesign Institute, Arizona State University)
Shoikhet, Yakov N (Department of Faculty Surgery, Altai State Medical University)
Lazarev, Alexander F (Altai territory branch of Russian Cancer Research Center)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.16, no.12, 2015 , pp. 4833-4837 More about this Journal
Abstract
Biomarkers for preclinical diagnosis of cancer are valuable tools for detection of malignant tumors at early stages in groups at risk and screening healthy people, as well as monitoring disease recurrence after treatment of cancer. However the complexity of the body's response to the pathological processes makes it virtually impossible to evaluate this response to the development of the disease using a single biomarker that is present in the serum at low concentrations. An alternative approach to standard biomarker analysis is called immunosignature. Instead of going after biomarkers themselves this approach rely on the analysis of the humoral immune response to molecular changes associated with the development of pathological processes. It is known that antibodies are produced in response to proteins expressed during cancer development. Accordingly, the changes in antibody repertoire associated with tumor growth can serve as biomarkers of cancer. Immunosignature is a highly sensitive method for antibody repertoire analysis utilizing high density peptide microarrays. In the present review we discuss modern methods for antibody detection, as well as describe the principles and applications of immunosignature in research and clinical practice.
Keywords
Antibodies; autoantibodies; immunosignature; cancer; biomarkers; peptide microarray; diagnostics;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
연도 인용수 순위
1 Anderson NL, Ptolemy AS, Rifai N (2013). The riddle of protein diagnostics: future bleak or bright? Clin Chem, 59, 194-7.   DOI
2 Azuma K, Komatsu N, Hattori S, et al (2014). Humoral immune responses to EGFR-derived peptides predict progression-free and overall survival of non-small cell lung cancer patients receiving gefitinib. PLoS One, 9, 86667.   DOI
3 Borrebaeck CA, Wingren C (2009). Design of high-density antibody microarrays for disease proteomics: key technological issues. J Proteomics, 72, 928-5.   DOI
4 Caron M, Choquet-Kastylevsky G, Joubert-Caron R (2007). Cancer immunomics using autoantibody signatures for biomarker discovery. Mol Cell Proteomics, 6, 1115-2.   DOI
5 Casiano CA, Mediavilla-Varela M, and Tan EM (2006). Tumor-associated antigen arrays for the serological diagnosis of cancer. Mol Cell Proteomics, 5, 1745-9.   DOI
6 Chapman CJ, Murray A, McElveen JE, et al (2008). Autoantibodies in lung cancer: possibilities for early detection and subsequent cure. Thorax, 63, 228-3.   DOI
7 Chapman C, Murray A, Chakrabarti J, et al (2007). Autoantibodies in breast cancer: their use as an aid to early diagnosis. Ann Oncol, 18, 868-3.   DOI
8 Chen YT, Scanlan MJ, Sahin U, et al (1997). A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening. Proc Natl Acad Sci U S A, 94, 1914-8.   DOI
9 Dai L, Li J, Ortega R, et al (2014). Preferential autoimmune response in prostate cancer to cyclin B1 in a panel of tumor-associated antigens. J Immunol Res, 2014, 827827.
10 Farlow EC, Vercillo MS, Coon JS, et al (2010). A multi-analyte serum test for the detection of non-small cell lung cancer. Br J Cancer, 103, 1221-8.   DOI
11 Fensterle, J., J. C. Becker, T. Potapenko, et al (2004). B-Raf specific antibody responses in melanoma patients. BMC Cancer, 4, 62.   DOI
12 Ferlay J, Soerjomataram I, Dikshit R, et al (2015). Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer, 136, 359-6.   DOI
13 Fernandez Madrid F (2005). Autoantibodies in breast cancer sera: candidate biomarkers and reporters of tumorigenesis. Cancer Lett, 230, 187-8.   DOI
14 Fushiki T, Fujisawa H, Eguchi S (2006). Identification of biomarkers from mass spectrometry data using a "common" peak approach. BMC Bioinformatics, 7, 358.   DOI
15 Fuzery AK, Levin J, Chan MM, Chan DW (2013). Translation of proteomic biomarkers into FDA approved cancer diagnostics: issues and challenges. Clin Proteomics, 10, 13.   DOI
16 Gnjatic S, Wheeler C, Ebner M, et al (2009). Seromic analysis of antibody responses in non-small cell lung cancer patients and healthy donors using conformational protein arrays. J Immunol Methods, 341, 50-8.   DOI
17 Grandjean M, Dieu M, Raes M, Feron O (2013). A new method combining sequential immunoaffinity depletion and differential in gel electrophoresis to identify autoantibodies as cancer biomarkers. J Immunol Methods, 396, 23-2.   DOI
18 Hori SS, Gambhir SS (2011). Mathematical model identifies blood biomarker-based early cancer detection strategies and limitations. Sci Transl Med, 3, 109-6
19 Hardouin J, Lasserre JP, Sylvius L, Joubert-Caron R, and Caron M (2007). Cancer immunomics: from serological proteome analysis to multiple affinity protein profiling. Ann N Y Acad Sci, 1107, 223-0.   DOI
20 Heo CK, Bahk YY, Cho EW (2012). Tumor-associated autoantibodies as diagnostic and prognostic biomarkers. BMB Rep, 45, 677-5.   DOI
21 Hughes AK, Cichacz Z., Scheck A, et al (2012). Immunosignaturing can detect products from molecular markers in brain cancer. PLoS One, 7, 40201.   DOI
22 Kellner R, Lichtenfels R, Atkins D, et al (2002). Targeting of tumor associated antigens in renal cell carcinoma using proteome-based analysis and their clinical significance. Proteomics, 2, 1743-1.   DOI
23 Klade CS, Voss T, Krystek E, et al (2001). Identification of tumor antigens in renal cell carcinoma by serological proteome analysis. Proteomics, 1, 890-8.   DOI
24 Koziol JA, Zhang JY, Casiano CA, et al (2003). Recursive partitioning as an approach to selection of immune markers for tumor diagnosis. Clin Cancer Res, 9, 5120-6.
25 Kroening K., Johnston SA, Legutki JB (2012). Autoreactive antibodies raised by self derived de novo peptides can identify unrelated antigens on protein microarrays. Are autoantibodies really autoantibodies? Exp Mol Pathol, 92, 304-1.   DOI
26 Kukreja M, Johnston SA, Stafford P (2012). Comparative study of classification algorithms for immunosignaturing data. BMC Bioinformatics, 13, 139.   DOI
27 MacBeath G, Schreiber SL (2000). Printing proteins as microarrays for high-throughput function determination. Science, 289, 1760-3.
28 Kulasingam V, Diamandis EP (2008). Strategies for discovering novel cancer biomarkers through utilization of emerging technologies. Nat Clin Pract Oncol, 5, 588-9.   DOI
29 Legutki JB, Magee DM, Stafford P, and Johnston SA (2010). A general method for characterization of humoral immunity induced by a vaccine or infection. Vaccine, 28, 4529-7.   DOI
30 Legutki JB, Zhao ZG, Greving M, et al (2014). Scalable high-density peptide arrays for comprehensive health monitoring. Nat Commun, 5, 4785.   DOI
31 Matsutani T, Hiwasa T, Takiguchi M, et al (2012). Autologous antibody to src-homology 3-domain GRB2-like 1 specifically increases in the sera of patients with low-grade gliomas. J Exp Clin Cancer Res, 31, 85.   DOI
32 O'Rourke D J, DiJohnson DA, Caiazzo RJ, et al (2012). Autoantibody signatures as biomarkers to distinguish prostate cancer from benign prostatic hyperplasia in patients with increased serum prostate specific antigen. Clin Chim Acta, 413, 561-7.   DOI
33 Parkin DM, Bray F, Ferlay J, Pisani P (2001). Estimating the world cancer burden: Globocan 2000. Int J Cancer, 94, 153-6.   DOI
34 Pulford, K, Falini B, Banham AH, et al (2000). Immune response to the ALK oncogenic tyrosine kinase in patients with anaplastic large-cell lymphoma. Blood, 96, 1605-7.
35 Qin JJ, Wang XR, Wang P, et al (2014). Mini-array of multiple tumor-associated antigens (TAAs) in the immunodiagnosis of esophageal cancer. Asian Pac J Cancer Prev, 15, 2635-0.   DOI
36 Shi XZ, Jin X, Xu P, Shen HM (2014). Relationship between breast cancer and levels of serum thyroid hormones and antibodies: a meta-analysis. Asian Pac J Cancer Prev, 15, 6643-7.   DOI
37 Restrepo L, Stafford P, Johnston SA (2013). Feasibility of an early Alzheimer's disease immunosignature diagnostic test. J Neuroimmunol, 254, 154-0.   DOI
38 Sawyers CL (2008). The cancer biomarker problem. Nature, 452, 548-2.   DOI
39 Scanlan MJ, Gordan JD, Williamson B, et al (1999). Antigens recognized by autologous antibody in patients with renal-cell carcinoma. Int J Cancer, 83, 456-4.   DOI
40 Stafford P, Cichacz Z, Woodbury NW, Johnston SA (2014). Immunosignature system for diagnosis of cancer. Proc Natl Acad Sci U S A, 111, 3072-0.   DOI
41 Stafford P, Halperin R, Legutki JB, et al (2012). Physical characterization of the "immunosignaturing effect. Mol Cell Proteomics, 11, 111.
42 Sykes KF, Legutki JB, Stafford P (2013). Immunosignaturing: a critical review. Trends Biotechnol, 31, 45-1.   DOI
43 Tan HT, Low J, Lim SG, Chung MC (2009). Serum autoantibodies as biomarkers for early cancer detection. FEBS J, 276, 6880-4.   DOI
44 Wang X, Yu J, Sreekumar A, et al (2005). Autoantibody signatures in prostate cancer. N Engl J Med, 353, 1224-5.   DOI   ScienceOn
45 Wang YQ, Zhang HH, Liu CL, et al (2012). Correlation between auto-antibodies to survivin and MUC1 variable number tandem repeats in colorectal cancer. Asian Pac J Cancer Prev, 13, 5557-2.   DOI
46 Zhong L, Peng X, Hidalgo GE, et al (2004). Identification of circulating antibodies to tumor-associated proteins for combined use as markers of non-small cell lung cancer. Proteomics, 4, 1216-5.   DOI   ScienceOn
47 Wu X, Molinaro C, Johnson N, Casiano CA (2001). Secondary necrosis is a source of proteolytically modified forms of specific intracellular autoantigens: implications for systemic autoimmunity. Arthritis Rheum, 44, 2642-2.   DOI
48 Zhang JY, Casiano CA, Peng XX, et al (2003). Enhancement of antibody detection in cancer using panel of recombinant tumor-associated antigens. Cancer Epidemiol Biomarkers Prev, 12, 136-3.