Opisthorchis viverrini Infection Activates the PI3K/AKT/PTEN and Wnt/β-catenin Signaling Pathways in a Cholangiocarcinogenesis Model |
Yothaisong, Supak
(Department of Biochemistry, Faculty of Medicine, Khon Kaen University)
Thanee, Malinee (Department of Biochemistry, Faculty of Medicine, Khon Kaen University) Namwat, Nisana (Department of Biochemistry, Faculty of Medicine, Khon Kaen University) Yongvanit, Puangrat (Department of Biochemistry, Faculty of Medicine, Khon Kaen University) Boonmars, Thidarut (Department of Parasitology, Faculty of Medicine, Khon Kaen University) Puapairoj, Anucha (Department of Pathology, Faculty of Medicine, Khon Kaen University) Loilome, Watcharin (Department of Biochemistry, Faculty of Medicine, Khon Kaen University) |
1 | Bachmann IM, Straume O, Puntervoll HE, et al (2005). Importance of P-cadherin, beta-catenin, and Wnt5a/frizzled for progression of melanocytic tumors and prognosis in cutaneous melanoma. Clin Cancer Res, 11, 8606-14. DOI |
2 | Da Forno PD, Pringle JH, Hutchinson P, et al (2008). WNT5A expression increases during melanoma progression and correlates with outcome. Clin Cancer Res, 14, 5825-32. DOI |
3 | Daorueang D, Thuwajit P, Roitrakul S, et al (2012). Secreted Opisthorchis viverrini glutathione S-transferase regulates cell proliferation through AKT and ERK pathways in cholangiocarcinoma. Parasitol Int, 61, 155-61. DOI |
4 | David O (2001). Akt and PTEN: new diagnostic markers of nonsmall cell lung cancer? J Cell Mol Med, 5, 430-3. DOI |
5 | Dokduang H, Juntana S, Techasen A, et al (2013). Survey of activated kinase proteins reveals potential targets for cholangiocarcinoma treatment. Tumour Biol, 34, 3519-28 DOI |
6 | Dokduang H, Techasen A, Namwat N, et al (2014). STATs profiling reveals predominantly-activated STAT3 in cholangiocarcinoma genesis and progression. J Hepatobiliary Pancreat Sci, 21, 767-76. DOI |
7 | Fenton TR, Nathanson D, Ponte de Albuquerque C, et al (2012). Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240. Proc Natl Acad Sci USA, 109, 14164-9. DOI |
8 | Gong C, Liao H, Wang J, et al (2012). LY294002 induces G0/G1 cell cycle arrest and apoptosis of cancer stem-like cells from human osteosarcoma via down-regulation of PI3K activity. Asian Pac J Cancer Prev, 13, 3103-7. DOI ScienceOn |
9 | Jannesari-Ladani F, Hossein G, Izadi-Mood N (2014). Differential Wnt11 expression related to Wnt5a in highand low-grade serous ovarian cancer: implications for migration, adhesion and survival. Asian Pac J Cancer Prev, 15, 1489-95. DOI |
10 | Koumakpayi IH, Le Page C, Mes-Masson AM, et al (2010). Hierarchical clustering of immunohistochemical analysis of the activated ErbB/PI3K/Akt/NF-kappaB signalling pathway and prognostic significance in prostate cancer. Br J Cancer, 102, 1163-73. DOI |
11 | Lim K, Han C, Xu L, et al (2008). Cyclooxygenase-2-derived prostaglandin E2 activates beta-catenin in human cholangiocarcinoma cells: evidence for inhibition of these signaling pathways by omega 3 polyunsaturated fatty acids. Cancer Res, 68, 553-60. DOI ScienceOn |
12 | Loilome W, Bungkanjana P, Techasen A, et al (2014). Activated macrophages promote Wnt/beta-catenin signaling in cholangiocarcinoma cells. Tumour Biol, 35, 5357-67. DOI |
13 | Loilome W, Juntana S, Namwat N, et al (2011). PRKAR1A is overexpressed and represents a possible therapeutic target in human cholangiocarcinoma. Int J Cancer, 129, 34-44. DOI |
14 | Loilome W, Yongvanit P, Wongkham C, et al (2006). Altered gene expression in Opisthorchis viverrini-associated cholangiocarcinoma in hamster model. Mol Carcinog, 45, 279-87. DOI |
15 | Namwat N, Chusorn P, Loilome W, et al (2012). Expression profiles of oncomir miR-21 and tumor suppressor let-7a in the progression of opisthorchiasis-associated cholangiocarcinoma. Asian Pac J Cancer Prev, 13, 65-9. |
16 | Sripa B, Kaewkes S, Sithithaworn P, et al (2007). Liver fluke induces cholangiocarcinoma. PLoS Med, 4, 201. DOI |
17 | Pandurangan AK (2013). Potential targets for prevention of colorectal cancer: a focus on PI3K/Akt/mTOR and Wnt pathways. Asian Pac J Cancer Prev, 14, 2201-5. DOI ScienceOn |
18 | Patel R, Gao M, Ahmad I, et al (2013). Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression. J Clin Invest, 123, 1157-75. DOI ScienceOn |
19 | Sithithaworn P, Haswell-Elkins M (2003). Epidemiology of Opisthorchis viverrini. Acta Trop, 88, 187-94. DOI |
20 | Sugimachi K, Taguchi K, Aishima S, et al (2001). Altered expression of beta-catenin without genetic mutation in intrahepatic cholangiocarcinoma. Mod Pathol, 14, 900-5. DOI |
21 | Tan HK, Moad AI, Tan ML (2014). The mTOR signalling pathway in cancer and the potential mTOR inhibitory activities of natural phytochemicals. Asian Pac J Cancer Prev, 15, 6463-75. DOI |
22 | Thamavit W, Bhamarapravati N, Sahaphong S, et al (1978). Effects of dimethylnitrosamine on induction of cholangiocarcinoma in opisthorchis viverrini-infected syrian golden hamsters. Cancer Res, 38, 4634-9. |
23 | Watanapa P, Watanapa WB (2002). Liver fluke-associated cholangiocarcinoma. Br J Surg, 89, 962-70. DOI |
24 | Xu X, Kobayashi S, Qiao W, et al (2006). Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. J Clin Invest, 116, 1843-52. DOI |
25 | Yang Z, Yuan XG, Chen J, et al (2013). Reduced expression of PTEN and increased PTEN phosphorylation at residue Ser380 in gastric cancer tissues: a novel mechanism of PTEN inactivation. Clin Res Hepatol Gastroenterol, 37, 72-9. DOI ScienceOn |
26 | Yuan G, Regel I, Lian F, et al (2013). WNT6 is a novel target gene of caveolin-1 promoting chemoresistance to epirubicin in human gastric cancer cells. Oncogene, 32, 375-87. DOI |
27 | Yongvanit P, Pinlaor S, Bartsch H (2012). Oxidative and nitrative DNA damage: key events in opisthorchiasis-induced carcinogenesis. Parasitol Int, 61, 130-5. DOI |
28 | Yothaisong S, Dokduang H, Techasen A, et al (2013). Increased activation of PI3K/AKT signaling pathway is associated with cholangiocarcinoma metastasis and PI3K/mTOR inhibition presents a possible therapeutic strategy. Tumour Biol, 34, 3637-48. DOI |
![]() |