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http://dx.doi.org/10.7314/APJCP.2014.15.23.10171

Differences in the Prognostic Significance of the SUVmax between Patients with Resected Pulmonary Adenocarcinoma and Squamous Cell Carcinoma  

Motono, Nozomu (Department of Thoracic Surgery, Kanazawa Medical University)
Ueno, Masakatsu (Department of Thoracic Surgery, Kanazawa Medical University)
Tanaka, Makoto (Department of Thoracic Surgery, Kanazawa Medical University)
Machida, Yuichiro (Department of Thoracic Surgery, Kanazawa Medical University)
Usuda, Katsuo (Department of Thoracic Surgery, Kanazawa Medical University)
Sakuma, Tsutomu (Department of Thoracic Surgery, Kanazawa Medical University)
Sagawa, Motoyasu (Department of Thoracic Surgery, Kanazawa Medical University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.23, 2015 , pp. 10171-10174 More about this Journal
Abstract
Background: The purpose of this study was to determine the prognostic significance of the maximum standardized uptake value (SUVmax) on F-18-fluorodeoxyglucose (FDG)-positron emission tomography (PET) in patients undergoing surgical treatment for non-small cell lung cancer. Materials and Methods: Seventy-eight consecutive patients (58 with adenocarcinomas, 20 with squamous cell carcinomas) treated with potentially curative surgery were retrospectively reviewed. Results: The SUVmax was significantly higher in the patients with recurrent than with non-recurrent adenocarcinoma (p<0.01). However, among the patients with squamous cell carcinoma, there were no differences with or without recurrence (p=0.69). Multivariate analysis indicated that the SUVmax of adenocarcinoma lesions was a significant predictor of disease-free survival (p=0.04). In addition, an SUVmax of 6.19, the cut-off point based on ROC curve analysis of the patients with pathological IB or more advanced stage adenocarcinomas, was found to be a significant predictor of disease-free survival (p<0.01). Conclusions: SUVmax is a useful predictor of disease-free survival in patients with resected adenocarcinoma, but not squamous cell carcinoma. Patients with adenocarcinoma exhibiting an SUVmax above 6.19 are candidates for more intensive adjuvant therapy.
Keywords
Non-small cell lung cancer; histologic type; PET; maximum standardized uptake value; prognosis;
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