Browse > Article
http://dx.doi.org/10.7314/APJCP.2014.15.9.4095

Association of the XRCC1 c.1178G>A Genetic Polymorphism with Lung Cancer Risk in Chinese  

Wang, Lei (Department of Respiratory Medicine, Shandong Jining NO.1 People's Hospital)
Lin, Yong (Department of Respiratory Medicine, Shandong Jining NO.1 People's Hospital)
Qi, Cong-Cong (Department of Respiratory Medicine, Shandong Jining NO.1 People's Hospital)
Sheng, Bao-Wei (Department of Respiratory Medicine, Shandong Jining NO.1 People's Hospital)
Fu, Tian (Department of Respiratory Medicine, Shandong Jining NO.1 People's Hospital)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.9, 2014 , pp. 4095-4099 More about this Journal
Abstract
The X-ray repair cross-complementing group 1 protein (XRCC1) plays important roles in the DNA base excision repair pathway which may influence the development of lung cancer. This study aimed to evaluate the potential association of the XRCC1 c.1178G>A genetic polymorphism with lung cancer risk. The created restriction site-polymerase chain reaction (CRS-PCR) and DNA sequencing methods were utilized to evaluate the XRCC1 c.1178G>A genetic polymorphism among 376 lung cancer patients and 379 controls. Associations between the genetic polymorphism and lung cancer risk were determined with an unconditional logistic regression model. Our data suggested that the distribution of allele and genotype in lung cancer patients was significantly different from that of controls. The XRCC1 c.1178G>A genetic polymorphism was associated with an increased risk of lung cancer (AA vs GG: OR=2.91, 95%CI 1.70-4.98, p<0.001; A vs G: OR=1.52, 95%CI 1.22-1.90, p<0.001). The allele A and genotype AA may contribute to risk of lung cancer. These preliminary results suggested that the XRCC1 c.1178G>A genetic polymorphism is statistically associated with lung cancer risk in the Chinese population.
Keywords
Lung cancer; XRCC1 gene; genetic polymorphisms; susceptibility;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 Zhang J, Zeng XT, Lei JR, et al (2014). No association between XRCC1 gene Arg194Trp polymorphism and risk of lung cancer: evidence based on an updated cumulative meta-analysis. Tumour Biol, 35, DOI: 10.1007/s13277-014-1745-z.   DOI   ScienceOn
2 Zhao CJ, Li N, Deng XM (2003). The establishment of method for identifying SNP genotype by CRS-PCR. Yi Chuan, 25, 327-9.
3 Wang R, Zhang Y, Zhang J, Zhi X (2014). Association of X-ray repair cross-complementing group 1 promoter rs3213245 polymorphism with lung cancer risk. Tumour Biol, 35, 1739-43.   DOI   ScienceOn
4 Viktorsson K, De Petris L, Lewensohn R (2005). The role of p53 in treatment responses of lung cancer. Biochem Biophys Res Commun, 331, 868-80.   DOI   ScienceOn
5 Wang JY, Cai Y (2013). X-ray repair cross-complementing group 1 codon 399 polymorphism and lung cancer risk: an updated meta-analysis. Tumour Biol, 35, DOI: 10.1007/s13277-014-1702-x.
6 Wang L, Chen Z, Wang Y, et al (2014). The association of c.1471G>A genetic polymorphism in XRCC1 gene with lung cancer susceptibility in Chinese Han population. Tumour Biol.
7 Wang Y, Yang H, Li H, et al (2009). Association between X-ray repair cross complementing group 1 codon 399 and 194 polymorphisms and lung cancer risk: a meta-analysis. Cancer Lett, 285, 134-40.   DOI   ScienceOn
8 Wu T, Xu YH, Ye XL (2013). X-ray repair cross-complementing group 1 Arg194Trp polymorphism is associated with increased risk of lung cancer in Chinese Han population. Tumour Biol, 34, 2611-5.   DOI   ScienceOn
9 Yin Z, Zhou B, He Q, et al (2009). Association between polymorphisms in DNA repair genes and survival of non-smoking female patients with lung adenocarcinoma. BMC Cancer, 9, 439.   DOI   ScienceOn
10 Yuan Z, Zeng X, Yang D, et al (2013). Effects of common polymorphism rs11614913 in Hsa-miR-196a2 on lung cancer risk. PLoS One, 8, 61047.   DOI
11 Yuan ZR, Li J, Li JY, et al (2013). SNPs identification and its correlation analysis with milk somatic cell score in bovine MBL1 gene. Mol Biol Rep, 40, 7-12.   DOI   ScienceOn
12 Perez-Morales R, Mendez-Ramirez I, Castro-Hernandez C, et al (2011). Polymorphisms associated with the risk of lung cancer in a healthy Mexican Mestizo population: Application of the additive model for cancer. Genet Mol Biol, 34, 546-52.   DOI   ScienceOn
13 Lopez-Cima MF, Gonzalez-Arriaga P, Garcia-Castro L, et al (2007). Polymorphisms in XPC, XPD, XRCC1, and XRCC3 DNA repair genes and lung cancer risk in a population of northern Spain. BMC Cancer, 7, 162.   DOI
14 Natukula K, Jamil K, Pingali UR, et al (2013). The codon 399 Arg/Gln XRCC1 polymorphism is associated with lung cancer in Indians. Asian Pac J Cancer Prev, 14, 5275-79.   과학기술학회마을   DOI   ScienceOn
15 Ouyang FD, Yang FL, Chen HC, et al (2013). Polymorphisms of DNA repair genes XPD, XRCC1, and OGG1, and lung adenocarcinoma susceptibility in Chinese population. Tumour Biol, 34, 2843-48.   DOI   ScienceOn
16 Qian B, Zhang H, Zhang L, et al (2011). Association of genetic polymorphisms in DNA repair pathway genes with non-small cell lung cancer risk. Lung Cancer, 73, 138-46.   DOI   ScienceOn
17 Rybarova S, Hodorova I, Muri J, et al (2011). Prognostic significance of p53 protein and X-ray repair cross-complementing protein 1 in non-small cell lung cancer. Tumori, 97, 79-85.   DOI
18 Karkucak M, Yakut T, Evrensel T, et al (2012). XRCC1 gene polymorphisms and risk of lung cancer in Turkish patients. Int J Hum Genet, 2, 113-7.
19 Siegel R, Naishadham D, Jemal A (2012). Cancer statistics, 2012. CA Cancer J Clin, 62, 10-29.   DOI   ScienceOn
20 Sun Y, Zhang YJ, Kong XM (2013). No association of XRCC1 and CLPTM1L polymorphisms with non-small cell lung cancer in a non-smoking Han Chinese population. Asian Pac J Cancer Prev, 14, 5171-4.   과학기술학회마을   DOI   ScienceOn
21 Huang G, Cai S, Wang W, et al (2013). Association between XRCC1 and XRCC3 polymorphisms with lung cancer risk: a meta-analysis from case-control studies. PLoS One, 8, 68457.   DOI
22 Huang J, Zhang J, Zhao Y, et al (2011). The Arg194Trp polymorphism in the XRCC1 gene and cancer risk in Chinese Mainland population: a meta-analysis. Mol Biol Rep, 38, 4565-73.   DOI
23 Kalikaki A, Kanaki M, Vassalou H, et al (2009). DNA repair gene polymorphisms predict favorable clinical outcome in advanced non-small-cell lung cancer. Clin Lung Cancer, 10, 118-23.   DOI   ScienceOn
24 Ke HG, Li J, Shen Y, et al (2012). Prognostic significance of GSTP1, XRCC1 and XRCC3 polymorphisms in non-small cell lung cancer patients. Asian Pac J Cancer Prev, 13, 4413-16.   과학기술학회마을   DOI   ScienceOn
25 Letkova L, Matakova T, Musak L, et al (2013). DNA repair genes polymorphism and lung cancer risk with the emphasis to sex differences. Mol Biol Rep, 40, 5261-73.   DOI   ScienceOn
26 Li D, Zhou Q, Liu Y, et al (2012). DNA repair gene polymorphism associated with sensitivity of lung cancer to therapy. Med Oncol, 29, 1622-28.   DOI   ScienceOn
27 Dai L, Duan F, Wang P, et al (2012). XRCC1 gene polymorphisms and lung cancer susceptibility: a meta-analysis of 44 case-control studies. Mol Biol Rep, 39, 9535-47.   DOI   ScienceOn
28 Li W, Li K, Zhao L, Zou H (2013). DNA repair pathway genes and lung cancer susceptibility: A meta-analysis. Gene, 538, 361-5.
29 Li Y, Huang XE, Jin GF, et al (2011). Lack of any relationship between chemotherapy toxicity in non-small cell lung cancer cases and polymorphisms in XRCC1 codon 399 or XPD codon 751. Asian Pac J Cancer Prev, 12, 739-42.
30 Li Y, Huang Y, Cao YS, et al (2013). Assessment of the association between XRCC1 Arg399Gln polymorphism and lung cancer in Chinese. Tumour Biol, 34, 3681-5.   DOI   ScienceOn
31 Chang JS, Wrensch MR, Hansen HM, et al (2009). Base excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African-Americans. Carcinogenesis, 30, 78-87.   DOI
32 Chen J, Zhao QW, Shi GM, Wang LR (2012). XRCC1 Arg399Gln and clinical outcome of platinum-based treatment for advanced non-small cell lung cancer: a meta-analysis in 17 studies. J Zhejiang Univ Sci B, 13, 875-83.
33 Cui Z, Yin Z, Li X, et al (2012). Association between polymorphisms in XRCC1 gene and clinical outcomes of patients with lung cancer: a meta-analysis. BMC Cancer, 12, 71.   DOI   ScienceOn
34 Giachino DF, Ghio P, Regazzoni S, et al (2007). Prospective assessment of XPD Lys751Gln and XRCC1 Arg399Gln single nucleotide polymorphisms in lung cancer. Clin Cancer Res, 13, 2876-81.   DOI   ScienceOn
35 Guilbert JJ (2003). The world health report 2002-reducing risks, promoting healthy life. Educ Health, 16, 230.   DOI   ScienceOn
36 Hao B, Miao X, Li Y, et al (2006). A novel T-77C polymorphism in DNA repair gene XRCC1 contributes to diminished promoter activity and increased risk of non-small cell lung cancer. Oncogene, 25, 3613-20.   DOI   ScienceOn
37 Guo QX, Yang WH, Zhai JF, et al (2013). XRCC1 codon 280 polymorphism and susceptibility to lung cancer: a meta-analysis of the literatures. Tumour Biol, 34, 2989-94.   DOI   ScienceOn
38 Guo S, Li X, Gao M, et al (2013). The relationship between XRCC1 and XRCC3 gene polymorphisms and lung cancer risk in northeastern Chinese. PLoS One, 8, 56213.   DOI
39 Haliassos A, Chomel JC, Tesson L, et al (1989). Modification of enzymatically amplified DNA for the detection of point mutations. Nucleic Acids Res, 17, 3606.   DOI
40 Butkiewicz D, Rusin M, Sikora B, et al (2011). An association between DNA repair gene polymorphisms and survival in patients with resected non-small cell lung cancer. Mol Biol Rep, 38, 5231-41.   DOI   ScienceOn
41 Sreeja L, Syamala VS, Syamala V, et al (2008). Prognostic importance of DNA repair gene polymorphisms of XRCC1 Arg399Gln and XPD Lys751Gln in lung cancer patients from India. J Cancer Res Clin Oncol, 134, 645-52.   DOI
42 Zhang Q, Jin H, Wang L, et al (2014). Lung cancer risk and genetic variants in East Asians: a meta-analysis. Tumour Biol, 35, DOI:10.1007/s13277-014-1671-0.   DOI   ScienceOn
43 Yuan ZR, Li JY, Li J, et al (2013). Effects of DGAT1 gene on meat and carcass fatness quality in Chinese commercial cattle. Mol Biol Rep, 40, 1947-54.   DOI   ScienceOn
44 Yuan ZR, Li JY, Li J, et al (2012). Investigation on BRCA1 SNPs and its effects on mastitis in Chinese commercial cattle. Gene, 505, 190-4.   DOI   ScienceOn
45 Yin J, Vogel U, Ma Y, et al (2009). Association of DNA repair gene XRCC1 and lung cancer susceptibility among nonsmoking Chinese women. Cancer Genet Cytogenet, 188, 26-31.   DOI   ScienceOn