Rapamycin and PF4 Induce Apoptosis by Upregulating Bax and Down-Regulating Survivin in MNU-Induced Breast Cancer |
Al-Astani Tengku Din, Tengku Ahmad Damitri
(Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia)
Shamsuddin, Shazana Hilda (Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia) Idris, Fauziah Mohamad (Department of Microbiology, Universiti Sains Malaysia) Wan Mansor, Wan Nor Ariffin (Biostatistic Unit, School of Medical Sciences, Universiti Sains Malaysia) Abdul Jalal, Muhammad Irfan (Institute for Research in Molecular Medicine (INFORMM), Health Campus, Universiti Sains Malaysia) Jaafar, Hasnan (Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia) |
1 | Zhou J, Luo YH, Wang JR, Lu BB, Tian Y (2013). Gambogenic acid induction of apoptosis in a breast cancer cell line. Asian Pac J Cancer Prev, 14, 7601-05. 과학기술학회마을 DOI ScienceOn |
2 | Verdecia M A, Huang Hk, Dutil E, et al (2000). Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement. Nature Structural Molec Biol, 7, 602-8. DOI ScienceOn |
3 | Yip C H, Taib N A, Mohamed I (2006). Epidemiology of breast cancer in Malaysia. Asian Pac J Cancer Prev, 7, 369-74. |
4 | Zhu N, Gu L, Findley H W, Li F, Zhou M (2004). An alternatively spliced survivin variant is positively regulated by p53 and sensitizes leukemia cells to chemotherapy. Oncogene, 23, 7545-51. DOI ScienceOn |
5 | Russo J, Russo I H (2000). Atlas and histologic classification of tumors of the rat mammary gland. J Mammary Gland Biol Neoplasia, 5, 187-200. DOI ScienceOn |
6 | Purcell J W, Davis J, Reddy M, et al (2010). Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer. Clinical Cancer Res, 16, 566-76. DOI ScienceOn |
7 | Reed J (1996). Balancing cell life and death: bax, apoptosis, and breast cancer. J Clin Invest, 97, 2403. DOI ScienceOn |
8 | Russo J, Russo I H (1995). The etiopathogenesis of breast cancer prevention. Cancer letters, 90, 81-9. DOI ScienceOn |
9 | Samkari A, Cooper Z A, Holloway M P, Liu J, Altura R A (2012). Rapamycin induces the anti-apoptotic protein survivin in neuroblastoma. Int J Biochem Mol Biol, 3, 28. |
10 | Shirouzu Y, Ryschich E, Salnikova O, et al (2010). Rapamycin inhibits proliferation and migration of hepatoma cells. J Surg Res, 159, 705-13. DOI ScienceOn |
11 | Shor B, Gibbons J J, Abraham R T, Yu K (2009). Targeting mTOR globally in cancer: thinking beyond rapamycin. Cell Cycle, 8, 3831-7. DOI |
12 | Signore M, Ricci-Vitiani L, De Maria R (2013). Targeting apoptosis pathways in cancer stem cells. Cancer letters, 332, 374-82. DOI ScienceOn |
13 | Tanaka K, Iwamoto S, Gon G, et al (2000). Expression of survivin and its relationship to loss of apoptosis in breast carcinomas. Clinical Cancer Res, 6, 127-34. |
14 | Thompson H J, McGinley J N, Rothhammer K, Singh M (1995). Rapid induction of mammary intraductal proliferations, ductal carcinoma in situ and carcinomas by the injection of sexually immature female rats with 1-methyl-1-nitrosourea. Carcinogenesis, 16, 2407-12. DOI ScienceOn |
15 | Jaafar H, Abdullah S, Murtey M D, Idris F M (2012). Expression of Bax and Bcl-2 in tumour cells and blood vessels of breast cancer and their association with angiogenesis and hormonal receptors. Asian Pac J Cancer Prev, 13, 3857-62. 과학기술학회마을 DOI ScienceOn |
16 | Jaafar H, Idris F M, Nafi S N M (2009). The association between phenotype and size of breast tumors induced by 1-methyl-1-nitrosourea (MNU) injection in rats. Med Sci Monit, 15. |
17 | Huang K, Huang Y, Diao Y (2012). Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K-AKT pathway. Int Immunopharmacol, 12, 334-41. DOI ScienceOn |
18 | Huynh H (2010). Molecularly targeted therapy in hepatocellular carcinoma. Biochemical Pharmacol, 80, 550-60. DOI ScienceOn |
19 | Jha K, Shukla M, Pandey M (2012). Survivin expression and targeting in breast cancer. Surgical Oncology, 21, 125-31. DOI ScienceOn |
20 | Jurgensmeier J M, Xie Z, Deveraux Q, et al (1998). Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci USA, 95, 4997-5002. DOI ScienceOn |
21 | Lu J, Tan M, Huang WC, et al (2009). Mitotic deregulation by survivin in ErbB2-overexpressing breast cancer cells contributes to Taxol resistance. Clin Cancer Res, 15, 1326-34. DOI ScienceOn |
22 | Maione T E, Gray G S, Hunt A J, Sharpe R J (1991). Inhibition of tumor growth in mice by an analogue of platelet factor 4 that lacks affinity for heparin and retains potent angiostatic activity. Cancer Res, 51, 2077-83. |
23 | Noh WC, Mondesire W H, Peng J, et al (2004). Determinants of rapamycin sensitivity in breast cancer cells. Clinical Cancer Res, 10, 1013-23. DOI ScienceOn |
24 | GLOBOCAN 2008 (IARC), S. o. C. I. (2008). Section of Cancer Information (29/8/2013) |
25 | Asanuma H, Torigoe T, Kamiguchi K, et al (2005). Survivin expression is regulated by coexpression of human epidermal growth factor receptor 2 and epidermal growth factor receptor via phosphatidylinositol 3-kinase/AKT signaling pathway in breast cancer cells. Cancer Res, 65, 11018-25. DOI ScienceOn |
26 | Ballou LM, Lin RZ (2008). Rapamycin and mTOR kinase inhibitors. J Chem Biol, 1, 27-36. DOI ScienceOn |
27 | Burz C, Berindan-Neagoe I, Balacescu O, Irimie A (2009). Apoptosis in cancer: key molecular signaling pathways and therapy targets. Acta oncologica, 48, 811-21. DOI ScienceOn |
28 | Gullino P, Pettigrew HM, Grantham F (1975). N-nitrosomethylurea as mammary gland carcinogen in rats. J Natl Cancer Inst, 54, 401-14. |
29 | Hassan Z K, Elamin M H, Omer S A, et al (2013). Oleuropein induces apoptosis via the p53 pathway in breast cancer cells. Asian Pac J Cancer Prev, 14, 6739-42. 과학기술학회마을 DOI ScienceOn |
30 | Hengartner M O (2000). The biochemistry of apoptosis. Nature, 407, 770-76. DOI ScienceOn |
31 | Namba R, Young L J, Abbey C K, et al (2006). Rapamycin inhibits growth of premalignant and malignant mammary lesions in a mouse model of ductal carcinoma in situ. Clinical Cancer Res, 12, 2613-21. DOI ScienceOn |
32 | Tan M L, Ooi J P, Ismail N, Moad A I H, Muhammad T S T (2009). Programmed cell death pathways and current antitumor targets. Pharmaceutical Res, 26, 1547-60. DOI ScienceOn |
33 | Hahm H, Davidson N (1998). Apoptosis in the mammary gland and breast cancer. Endocrine-related cancer, 5, 199-211. DOI ScienceOn |
34 | Wan L Z, Hu N, Liu XJ, et al (2014). Fangchinoline Inhibits cell proliferation via Akt/GSK-3beta/cyclin D1 signaling and induces apoptosis in MDA-MB-231 breast cancer cells. Asian Pac J Cancer Prev, 15, 769-73. 과학기술학회마을 DOI ScienceOn |