Browse > Article
http://dx.doi.org/10.7314/APJCP.2014.15.9.3911

Application of Tumor Markers SCC-Ag, CEA, and TPA in Patients with Cervical Precancerous Lesions  

Farzaneh, Farah (Preventive Gynecology Research Center, Department of Obstetrics and Gynecology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences)
Shahghassempour, Shapour (Tissue Engineering and Nanomedicine Research Center, Taleghani Teaching Hospital, Shahid Beheshti University of Medical Sciences)
Noshine, Bahram (Tissue Engineering and Nanomedicine Research Center, Taleghani Teaching Hospital, Shahid Beheshti University of Medical Sciences)
Arab, Maliheh (Preventive Gynecology Research Center, Department of Obstetrics and Gynecology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences)
Yaseri, Mehdi (Clinical Research and Development Center, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences)
Rafizadeh, Mitra (Department of Pathology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences)
Alizadeh, Kamyab (Preventive Gynecology Research Center, Department of Obstetrics and Gynecology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.9, 2014 , pp. 3911-3914 More about this Journal
Abstract
Background: To determine the potential clinical utility of tumor markers CEA, TPA, and SCC-Ag for early detection of cervical precancerous lesions. Materials and Methods: A case-control study was carried out on 120 women (46 patients with histologically confirmed cervical precancerous lesions and 74 healthy controls). The significance of serum selected tumor markers in early detection of cervical intraepithelial neoplasia (CIN) were assessed. Results: Of the case group, the rates of CIN I, II, III, was 69.6%, 23.9%, and 6.5%, respectively. According to the manufacturer's cut-off values of 2ng/ml, 5ng/ml, and 70 U/ml for SCC-Ag, CEA and TPA tests, in that order, SCC-Ag test had a sensitivity of 13%, but CEA and TPA tests could not distinguish between case and control groups. The diagnostic sensitivities were highest at cut-off values of 0.55 ng/ml for SCC-Ag, 2.6ng/ml for CEA, and 25.5 U/ml for TPA which were 93%, 61%, and 50%, respectively. However, the area under the receiver operating characteristic curve was the largest for SCC-Ag (0.95 vs. 0.61 and 0.60 for CEA and TPA, respectively). Moreover, there was a highly significant direct correlation between SCC-Ag concentration and the degree of cervical precancerous lesions (r=0.847, p<0.001). Conclusions: The new cutoff of 0.5 for SCC-Ag test might be useful as a tumor marker in Iranian patients with CIN and it needs to be more evaluated by studies with larger populationa.
Keywords
Cervical cancer; CIN; SCC antigen; TPA antigen; carcinoembryonic antigen; tumour markers;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Tendler A, Kaufman HL, Kadish AS (2000). Increased carcinoembryonic antigen expression in cervical intraepithelial neoplasia grade 3 and in cervical squamous cell carcinoma. Hum Pathol, 31, 1357-62.   DOI   ScienceOn
2 Volgger B, Aspisirengil C, Genser-Krimbacher E, et al (2008). Prognostic significance of TPA versus SCC-Ag, CEA and neopterin in carcinoma of the uterine cervix. Cancer Lett, 262, 183-9.   DOI   ScienceOn
3 Wallace D, Hunter J, Papenfuss M, et al (2007). Pap smear screening among women >/=40 years residing at the United States-Mexico border. Health Care Women Int, 28, 799-816.   DOI   ScienceOn
4 Jesdapatarakul S, Tangjitgamol S, Nguansangiam S, Manusirivithaya S (2011). Liqui-Prep(R) versus conventional Papanicolaou smear to detect cervical cells abnormality by split-sample technique: a randomized double-blind controlled trial. Diagn Cytopathol, 39, 22-7.   DOI   ScienceOn
5 Juang CM, Wang PH, Yen MS, et al (2000). Application of tumor markers CEA, TPA, and SCC-Ag in patients with low-risk FIGO stage IB and IIA squamous cell carcinoma of the uterine cervix. Gynecol Oncol, 76, 103-6.   DOI   ScienceOn
6 Kato H, Torigoe T (1977). Radioimmunoassay for tumor antigen of human cervical squamous cell carcinoma. Cancer, 40, 1621-8.   DOI
7 Mousavi SM, Gouya MM, Ramazani R, et al (2009). Cancer incidence and mortality in Iran. Ann Oncol, 20, 556-63.
8 Parkin DM, Almonte M, Bruni L, et al (2008). Burden and trends of type-specific human papillomavirus infections and related diseases in the Latin America and Caribbean region. Vaccine, 11, 1-15.
9 Porika M, Vemunoori AK, Tippani R, et al (2010). Squamous cell carcinoma antigen and cancer antigen 125 in Southern Indian cervical cancer patients. Asian Pac J Cancer Prev, 11, 1745-7.
10 Reesink-Peters N, van der Velden J, Ten Hoor KA, et al (2005). Preoperative serum squamous cell carcinoma antigen levels in clinical decision making for patients with early-stage cervical cancer. J Clin Oncol, 23, 1455-62.   DOI   ScienceOn
11 Takeshima N, Hirai Y, Katase K, et al (1998). The value of squamous cell carcinoma antigen as a predictor of nodal metastasis in cervical cancer. Gynecol Oncol, 68, 263-6.   DOI   ScienceOn
12 Forni F, Ferrandina G, Deodato F, et al (2007). Squamous cell carcinoma antigen in follow-up of cervical cancer treated with radiotherapy: evaluation of cost-effectiveness. Int J Radiat Oncol Biol Phys, 69, 1145-9.   DOI   ScienceOn
13 Chen C, Yang Z, Li Z Li L (2012). Accuracy of several cervical screening strategies for early detection of cervical cancer: a meta-analysis. Int J Gynecol Cancer, 22, 908-21.   DOI   ScienceOn
14 Cuzick J, Arbyn M, Sankaranarayanan R, et al (2008). Overview of human papillomavirus-based and other novel options for cervical cancer screening in developed and developing countries. Vaccine, 10, 29-41.
15 Esajas MD, Duk JM, de Bruijn HW, et al (2001). Clinical value of routine serum squamous cell carcinoma antigen in follow-up of patients with early-stage cervical cancer. J Clin Oncol, 19, 3960-6.   DOI
16 Gadducci A, Cosio S, Carpi A, Nicolini A, Genazzani AR (2004). Serum tumor markers in the management of ovarian, endometrial and cervical cancer. Biomed Pharmacother, 58, 24-38.   DOI   ScienceOn
17 Jeong BK, Choi DH, Huh SJ, et al (2011). The role of squamous cell carcinoma antigen as a prognostic and predictive factor in carcinoma of uterine cervix. Radiat Oncol J, 29, 191-8.   DOI   ScienceOn
18 Hong JH, Tsai CS, Chang JT, et al (1998). The prognostic significance of pre- and posttreatment SCC levels in patients with squamous cell carcinoma of the cervix treated by radiotherapy. Int J Radiat Oncol Biol Phys, 41, 823-30.   DOI   ScienceOn
19 Indarti J, Aziz MF, Suryawati B, Fernando D (2013). Scoring system and management algorithm assessing the role of survivin expression in predicting progressivity of HPV infections in precancerous cervical lesions. Asian Pac J Cancer Prev, 14, 1643-7.   과학기술학회마을   DOI   ScienceOn
20 Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90.   DOI
21 Mathew A, George PS (2009). Trends in incidence and mortality rates of squamous cell carcinoma and adenocarcinoma of cervix--worldwide. Asian Pac J Cancer Prev, 10, 645-50.