Browse > Article
http://dx.doi.org/10.7314/APJCP.2014.15.9.3895

Expression of C4.4A is a Potential Independent Prognostic Factor for Patients with Gastric Cancer  

Cheng, Da-Qing (Department of General Surgery, Huashan Hospital, Fudan University)
Gu, Xiao-Dong (Department of General Surgery, Huashan Hospital, Fudan University)
Li, Zhen-Yang (Department of General Surgery, Huashan Hospital, Fudan University)
Xiang, Jian-Bin (Department of General Surgery, Huashan Hospital, Fudan University)
Chen, Zong-You (Department of General Surgery, Huashan Hospital, Fudan University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.9, 2014 , pp. 3895-3899 More about this Journal
Abstract
C4.4A, a metastasis-associated gene, encodes a glycolipid-anchored membrane protein which is overexpressed in several human malignancies. However, there are few data available on C4.4A expression and its relationship with progression in gastric cancer. Our study was designed to explore the expression of C4.4A in gastric cancer and to correlate it with clinical outcome. C4.4A expression was studied by quantitative real-time RT-PCR and immunohistochemistry for assessment of correlations with clinicopathological factors. C4.4A mRNA expression was significantly up-regulated in gastric cancer as compared with noncancerous tissue (p<0.05)., being observed in 107 (88.4%) of the 121 gastric cancer cases by immunohistochemistry. We found that the expression of C4.4A mRNA was correlated with size of the tumor, depth of invasion, lymph node metastasis, distant metastasis and TNM stage. Moreover, patients with overexpression of C4.4A has a significantly worse survival (p<0.05). Further multivariable analysis indicated that the expression of C4.4A was an independent prognostic indicator for gastric cancer (p<0.05). In conclusion, overexpression of C4.4A correlates with metastatic potential of gastric cancer and C4.4A could be a novel independent prognostic marker for predicting outcome.
Keywords
C4.4A; gastric cancer; prognosis; metastasis;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Wurfel J, Seiter S, Stassar M, et al (2001). Cloning of the human homologue of the metastasis-associated rat C4.4A. Gene, 262, 35-41.   DOI   ScienceOn
2 Smith BA, Kennedy WJ, Harnden P, et al (2001). Identification of genes involved in human urothelial cell-matrix interactions: implications for the progression pathways of malignant urothelium. Cancer Res, 61, 1678-85.
3 Udayakumar TS, Chen ML, Bair EL, et al (2003). Membrane type-1-matrix metalloproteinase expressed by prostate carcinoma cells cleaves human laminin-5 beta3 chain and induces cell migration. Cancer Res, 63, 2292-9.
4 Wang J, Yu JC, Kang WM, Ma ZQ (2012). Treatment strategy for early gastric cancer. Surg Oncol, 21, 119-23.   DOI   ScienceOn
5 Yamamoto H, Oshiro R, Ohtsuka M, et al (2013). Distinct expression of C4.4A in colorectal cancer detected by different antibodies. Int J Oncol, 42, 197-201.   DOI
6 Mondino A, Resnati M, Blasi F (1999). Structure and function of the urokinase receptor. Thromb Haemost, 82, 19-22.
7 Li FX, Zhang RP, Liang H, et al (2013). Validity and necessity of sub-classification of N3 in the 7th UICC TNM stage of gastric cancer. Asian Pac J Cancer Prev, 14, 2091-5.   과학기술학회마을   DOI   ScienceOn
8 Ma YY, Tao HQ (2012). Role of urokinase plasminogen activator receptor in gastric cancer: a potential therapeutic target. Cancer Biother Radiopharm, 27, 285-90.   DOI   ScienceOn
9 Matzku S, Wenzel A, Liu S, Zoller M (1989). Antigenic differences between metastatic and nonmetastatic BSp73 rat tumor variants characterized by monoclonal antibodies. Cancer Res, 49, 1294-9.
10 Omejc M, Juvan R, Jelenc F, Repse S (2001). Lymph node metastases in gastric cancer: correlation between new and old UICC TNM classification. Int Surg, 86, 14-9.
11 Paret C, Bourouba M, Beer A, et al (2005). Ly6 family member C4.4A binds laminins 1 and 5, associates with galectin-3 and supports cell migration. Int J Cancer, 115, 724-33.   DOI   ScienceOn
12 Paret C, Hildebrand D, Weitz J, et al (2007). C4.4A as a candidate marker in the diagnosis of colorectal cancer. Br J Cancer, 97, 1146-56.   DOI   ScienceOn
13 Rosel M, Claas C, Seiter S, Herlevsen M, Zoller M (1998). Cloning and functional characterization of a new phosphatidyl-inositol anchored molecule of a metastasizing rat pancreatic tumor. Oncogene, 17, 1989-2002.   DOI
14 Sadowski T, Dietrich S, Koschinsky F, et al (2005). Matrix metalloproteinase 19 processes the laminin 5 gamma 2 chain and induces epithelial cell migration. Cell Mol Life Sci, 62, 870-80.   DOI
15 Hansen LV, Gardsvoll H, Nielsen BS, et al (2004). Structural analysis and tissue localization of human C4.4A: a protein homologue of the urokinase receptor. Biochem J, 380, 845-57.   DOI   ScienceOn
16 Seiter S, Stassar M, Rappl G, et al (2001). Upregulation of C4.4A expression during progression of melanoma. J Invest Dermatol, 116, 344-7.   DOI   ScienceOn
17 Hansen LV, Laerum OD, Illemann M, Nielsen BS, Ploug M (2008). Altered expression of the urokinase receptor homologue, C4.4A, in invasive areas of human esophageal squamous cell carcinoma. Int J Cancer, 122, 734-41.   DOI   ScienceOn
18 Gao XH, Yang XQ, Wang BC, Liu SP, Wang FB (2013). Overexpression of twist and matrix metalloproteinase-9 with metastasis and prognosis in gastric cancer. Asian Pac J Cancer Prev, 14, 5055-60.   과학기술학회마을   DOI   ScienceOn
19 Hansen LV, Skov BG, Ploug M, Pappot H (2007). Tumour cell expression of C4.4A, a structural homologue of the urokinase receptor, correlates with poor prognosis in non-small cell lung cancer. Lung Cancer, 58, 260-6.   DOI   ScienceOn
20 Hartgrink HH, Jansen EP, van Grieken NC, van de Velde CJ (2009). Gastric cancer. Lancet, 374, 477-90.   DOI   ScienceOn
21 Jacobsen B, Ploug M (2008). The urokinase receptor and its structural homologue C4.4A in human cancer: expression, prognosis and pharmacological inhibition. Curr Med Chem, 15, 2559-73.   DOI   ScienceOn
22 Jemal A, Center MM, DeSantis C, Ward EM (2010). Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev, 19, 1893-907.   DOI   ScienceOn
23 Frank DE, Carter WG (2004). Laminin 5 deposition regulates keratinocyte polarization and persistent migration. J Cell Sci, 117, 1351-63.   DOI   ScienceOn
24 Konishi K, Yamamoto H, Mimori K, et al (2010). Expression of C4.4A at the invasive front is a novel prognostic marker for disease recurrence of colorectal cancer. Cancer Sci, 101, 2269-77.   DOI   ScienceOn
25 Esselens CW, Malapeira J, Colome N, et al (2008). Metastasis-associated C4.4A, a GPI-anchored protein cleaved by ADAM10 and ADAM17. Biol Chem, 389, 1075-84.
26 Fletcher GC, Patel S, Tyson K, et al (2003). hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan. Br J Cancer, 88, 579-85.   DOI   ScienceOn
27 Fries F, Nazarenko I, Hess J, et al (2007). CEBPbeta, JunD and c-Jun contribute to the transcriptional activation of the metastasis-associated C4.4A gene. Int J Cancer, 120, 2135-47.   DOI   ScienceOn