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http://dx.doi.org/10.7314/APJCP.2014.15.8.3641

Positive Effects of Oral β-Glucan on Mucositis and Leukopenia in Colorectal Cancer Patients Receiving Adjuvant FOLFOX-4 Combination Chemotherapy  

Karaca, Halit (Department of Medical Oncology, Erciyes University Medical Faculty)
Bozkurt, Oktay (Department of Medical Oncology, Erciyes University Medical Faculty)
Ozaslan, Ersin (Department of Medical Oncology, Erciyes University Medical Faculty)
Baldane, Suleyman (Department of Internal Medicine, Erciyes University Medical Faculty)
Berk, Veli (Department of Medical Oncology, Erciyes University Medical Faculty)
Inanc, Mevlude (Department of Medical Oncology, Erciyes University Medical Faculty)
Duran, Ayse Ocak (Department of Medical Oncology, Erciyes University Medical Faculty)
Dikilitas, Mustafa (Department of Medical Oncology, Acibadem Hospital)
Er, Ozlem (Department of Medical Oncology, Acibadem Hospital)
Ozkan, Metin (Department of Medical Oncology, Erciyes University Medical Faculty)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.8, 2014 , pp. 3641-3644 More about this Journal
Abstract
The present study aimed to determine the effect of oral ${\beta}$-glucan on mucositis and leukopenia in 62 consecutive patients with colorectal cancer treated with an adjuvant FOLFOX-4 regimen. The patients were retrospectively evaluated in 2 groups: one group received ${\beta}$-glucan and the other did not (control group). Leucocytes, neutrophils, and platelets were evaluated before and 1 week after chemotherapy and oral mucositis and diarrhea were noted. Leucocyte and neutrophil counts after chemotherapy in the ${\beta}$-glucan group were $7,300/mm^3$ and $3,800/mm^3$, respectively, and the reductions, as compared to baseline, were not significant (p=0.673 and 0.784). The median platelet count was $264,000/mm^3$ after chemotherapy in the ${\beta}$-glucan group and the reduction, as compared to baseline, was borderline significant (p=0.048). In the control group, reduction in leucocyte, neutrophil, and platelet counts was statistically significant. Oral mucositis and diarrhea were less common in the ${\beta}$-glucan group. We conclude that ${\beta}$-glucan can be used to reduce the adverse effects of chemotherapy.
Keywords
${\beta}$-glucan; chemotherapy; neutropenia; mucositis; colorectal cancer;
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