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http://dx.doi.org/10.7314/APJCP.2014.15.8.3635

Induced Abortion and Breast Cancer: Results from a Population-Based Case Control Study in China  

Wu, Jun-Qing (Department of Epidemiology and Social Science on RH, Shanghai Institute of Planned Parenthood Research, WHO Collaborating Center on Human Research on Reproductive Health)
Li, Yu-Yan (Department of Epidemiology and Social Science on RH, Shanghai Institute of Planned Parenthood Research, WHO Collaborating Center on Human Research on Reproductive Health)
Ren, Jing-Chao (College of Medical in Xinxiang)
Zhao, Rui (Department of Epidemiology and Social Science on RH, Shanghai Institute of Planned Parenthood Research, WHO Collaborating Center on Human Research on Reproductive Health)
Zhou, Ying (Department of Epidemiology and Social Science on RH, Shanghai Institute of Planned Parenthood Research, WHO Collaborating Center on Human Research on Reproductive Health)
Gao, Er-Sheng (Department of Epidemiology and Social Science on RH, Shanghai Institute of Planned Parenthood Research, WHO Collaborating Center on Human Research on Reproductive Health)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.8, 2014 , pp. 3635-3640 More about this Journal
Abstract
Aim: To determine whether induced abortion (IA) increases breast cancer (BC) risk. Materials and Methods: A population-based case-control study was performed from Dec, 2000 to November, 2004 in Shanghai, China, where IA could be verified through the family planning network and client medical records. Structured questionnaires were completed by 1,517 cases with primary invasive epithelial breast cancer and 1,573 controls frequency-matched to cases for age group. The information was supplemented and verified by the family planning records. Statistical analysis was conducted with SAS 9.0. Results: After adjusting for potential confounders, induced abortions were not found to be associated with breast cancer with OR=0.94 (95%CI= 0.79-1.11). Compared to parous women without induced abortion, parous women with 3 or more times induced abortion (OR=0.66, 95%CI=0.46 to 0.95) and women with 3 or more times induced abortion after the first live birth (OR=0.66, 95%CI =0.45 to 0.97) showed a lower risk of breast cancer, after adjustment for age, level of education, annual income per capita, age at menarche, menopause, parity times, spontaneous abortion, age at first live birth, breast-feeding, oral contraceptives, hormones drug, breast disease, BMI, drinking alcohol, drinking tea, taking vitamin/calcium tablet, physical activity, vocation, history of breast cancer, eating the bean. Conclusions: The results suggest that a history of induced abortions may not increase the risk of breast cancer.
Keywords
Breast cancer; induced abortion; case control study;
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1 Ozmen V, Ozcinar B, Karanlik H, et al (2009). Breast cancer risk factors in Turkish women-a University Hospital based nested case control study. World J Surg Oncol, 7, 37.   DOI   ScienceOn
2 Hulka BS, Moorman PG (2001). Breast cancer: hormones and other risk factors. Maturitas, 38, 103-16.   DOI   ScienceOn
3 Henderson KD, Sullivan-Halley J, Reynolds P, et al (2008). Incomplete pregnancy is not associated with breast cancer risk: the California Teachers Study. Contraception, 77, 391-6.   DOI   ScienceOn
4 Hadjisavvas A, Loizidou MA, Middleton N, et al (2010). An investigation of breast cancer risk factors in Cyprus: a case control study. BMC Cancer, 10, 447.   DOI   ScienceOn
5 Mahue-Giangreco M, Ursin G, Sullivan-Halley J, et al (2003). Induced abortion, miscarriage, and breast cancer risk of young women. Cancer Epidemiol Biomarkers Prev, 12, 209-14.
6 Michels KB, Xue F, Colditz GA, et al (2007). Induced and spontaneous abortion and incidence of breast cancer among young women: a prospective cohort study. Arch Intern Med, 167, 814-20.   DOI   ScienceOn
7 Jemal A, Center MM, Desantis C, et al (2010). Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev, 19, 1893-907.   DOI   ScienceOn
8 Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90.   DOI
9 Jiang AR, Gao CM, Ding JH, et al (2012). Abortions and breast cancer risk in premenopausal and postmenopausal women in Jiangsu Province in China. Asian Pac J Cancer Prev, 13, 33-5.   과학기술학회마을   DOI   ScienceOn
10 Coleman PK, Rue VM, Coyle CT (2009). Induced abortion and intimate relationship quality in the Chicago Health and Social Life Survey. Public Health, 4, 331-8.
11 Costarelli V, Yiannakouris N (2010). Breast cancer risk in women: the protective role of pregnancy. Nurs Stand, 24, 35-40.
12 Michels KB, Hsieh CC, Trichopoulos D, et al (1995). Abortion and breast cancer risk in seven countries. Cancer Causes Control, 6, 75-82.   DOI   ScienceOn
13 Ministry of Public Health of the People's Republic of China (2010). China Statistical Yearbook. Publishing House of China Statistics, Beijing, 207.
14 Naieni KH, Ardalan A, Mahmoodi M, et al (2007). Risk factors of breast cancer in north of Iran: a case-control in Mazandaran Province. Asian Pac J Cancer Prev, 8, 395-8.
15 Russo J, Russo IH (1987). Biological and molecular bases of mammary carcinogenesis. Lab Invest, 57, 112-37.
16 Russo IH, Koszalka M, Russo J (1991). Comparative study of the influence of pregnancy and hormonal treatment on mammary carcinogenesis. Br J Cancer, 64, 481-4.   DOI   ScienceOn
17 Sanderson M, Shu XO, Jin F, et al (2001). Abortion history and breast cancer risk: results from the Shanghai Breast Cancer Study. Int J Cancer, 92, 899-905.   DOI   ScienceOn
18 Thorp JM, Hartmann KE, Shadigian E (2003). Long-term physical and psychological health consequences of induced abortion: review of the evidence. Obstet Gynecol Surv, 58, 67-7.   DOI   ScienceOn
19 Ye Z, Gao DL, Qin Q, et al (2002). Breast cancer in relation to induced abortions in a cohort of Chinese women. Br J Cancer, 87, 977-81.   DOI   ScienceOn
20 Yan Zhou, Jingrong Xiao, Huijuan Jiang (2010). Incidence trend of female breast cancer in Fuzhou city, 1991-2005. Chin J Nat Med, 12, 183-5.
21 Lindefors-Harris BM, Edklund G, Meirik O, et al (1989). Risk of cancer of the breast after legal abortion during first trimester: a Swedish register study. BMJ, 299, 1430-2.   DOI
22 Friedman E, Kotsopoulos J, Lubinski, J, et al (2006). Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers. Breast Cancer Res, 8, R15.   DOI   ScienceOn
23 Daling JR, Brinton LA, Voigt LF, et al (1996). Risk of breast cancer among white women following induced abortion. Am J Epidemiol, 144, 373-80.   DOI   ScienceOn
24 Dandan He, Chunfang Wang, Lili Cao, et al (2010). Epidemic trend of female breast cancer incidence in Minhang district, Shanghai. China Cancer, 19, 108-10.
25 Erlandsson G, Montgomery SM, Cnattingius S, et al (2003). Abortions and breast cancer: record-based case-control study. Int J Cancer, 103, 676-9.   DOI   ScienceOn
26 Yanhua C, Greater A, You J, et al (2012). Reproductive variables and risk of breast malignant and benign tumours in Yunnan province, China. Asian Pac J Cancer Prev, 13, 2179-84.   과학기술학회마을   DOI   ScienceOn
27 Toleutay U, Reznik V, Kalmatayeva Z, et al (2013). Risk factors of breast cancer in Kyzylorda oblast of Kazakhstan: a casecontrol study. Asian Pac J Cancer Prev, 14, 5961-4.   과학기술학회마을   DOI   ScienceOn
28 Ma H, Henderson KD, Sullivan-Halley J, et al (2010). Pregnancy-related factors and the risk of breast carcinoma in situ and invasive breast cancer among postmenopausal women in the California Teachers Study cohort. Breast Cancer Res, 12, 35.