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http://dx.doi.org/10.7314/APJCP.2014.15.7.3323

Locally Advanced Breast Cancer in Jamaica: Prevalence, Disease Characteristics and Response to Preoperative Therapy  

Chin, Sheray Nicole (Department of Pathology, University of the West Indies)
Green, Cheryl May Antoinette (Department of Pathology, University of the West Indies)
Gordon-Strachan, Georgiana Marie (Faculty of Medical Sciences, University of the West Indies)
Wharfe, Gilian Helen Frances (Department of Pathology, University of the West Indies)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.7, 2014 , pp. 3323-3326 More about this Journal
Abstract
Breast cancer is the most common cancer in Jamaican women. Locally advanced breast cancer (LABC) is associated with aggressive biology and poor prognosis, and has a predilection for African-American women. In this retrospective review, we assessed the prevalence of LABC as a breast cancer presentation in a population of mainly Afro-centric ethnicity, and determined disease characteristics and response to pre-operative chemotherapy. LABC was prevalent (20%), and had a low pathological response rate to pre-operative chemotherapy, with a high risk of disease recurrence. Increased utilization of breast cancer screening may help detect cancer at less advanced stages, and optimizing pre-operative chemotherapy is recommended to improve response rates and ultimately survival.
Keywords
Breast cancer; locally advanced breast cancer; neoadjuvant chemotherapy; preoperative chemotherapy;
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