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http://dx.doi.org/10.7314/APJCP.2014.15.7.3261

Serum Vascular Endothelial Growth Factor-A (VEGF-A) as a Biomarker in Squamous Cell Carcinoma of Head and Neck Patients Undergoing Chemoradiotherapy  

Srivastava, Vikas Kumar (Department of Radiotherapy, King George's Medical University)
Gara, Rishi Kumar (Department of Endocrinology, Central Drug Research Institute)
Rastogi, Namrata (Department of Endocrinology, Central Drug Research Institute)
Mishra, Durga Prasad (Department of Endocrinology, Central Drug Research Institute)
Ahmed, Mohd Kaleem (Department of Biochemistry, King George's Medical University)
Gupta, Shalini (Department of Oral Pathology, King George's Medical University)
Goel, Madhu Mati (Department of Pathology, King George's Medical University)
Bhatt, Madan Lal Brahma (Department of Radiation Oncology, Dr. Ram Manohar Lohia Institute of Medical Sciences)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.7, 2014 , pp. 3261-3265 More about this Journal
Abstract
Background: To evaluate serum VEGF-A levels in squamous cell carcinoma of head and neck (SCCHN) patients and relationships with response to therapy. Materials and Methods: Serum VEGF-A levels in patients (n=72) treated with radiotherapy (RT) or radio-chemotherapy (RCT) and controls (n=40) were measured by ELISA. Results: Serum VEGF-A levels of the SCCHN cases were significantly higher (p=0.001) than in healthy controls, and in patients with positive as compared to negative lymph node status (p=0.004). Similarly, patients with advanced stage (Stage III-IV) disease had more greatly elevated levels of serum VEGF-A level than their early stage (Stage I-II) counterparts (p=0.001). In contrast, there was no significant difference (p=0.57) in serum level of VEGF-A in patients with advanced T-stage (T3-4) as compared to early stage (T1-2). Similarly, patients with distant metastasis had no significant (p=0.067) elevation in serum VEGF-A level as compared to non-metastatic disease. However, the non-responder patients had significantly higher serum VEGF-A level as compared to responders (p=0.001). Conclusions: Our results suggest that the serum VEGF-A level may be a useful biomarker for the prediction of response to therapy in SCCHN.
Keywords
VEGF-A; squamous cell carcinoma of head and neck; serum levels; prognostic marker;
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