Inotodiol Inhabits Proliferation and Induces Apoptosis through Modulating Expression of cyclinE, p27, bcl-2, and bax in Human Cervical Cancer HeLa Cells |
Zhao, Li-Wei
(Department of Pathology, Jilin Medical College)
Zhong, Xiu-Hong (Department of Pathology, Jilin Medical College) Yang, Shu-Yan (Department of Pathology, Jilin Medical College) Zhang, Yi-Zhong (Department of Pathology, Jilin Medical College) Yang, Ning-Jiang (Department of Pathology, Affiliated Hospital of Jilin Medical College) |
1 | Lim S, Kaldis P (2013). Cdks, cyclins and CKIs: roles beyond cell cycle regulation. Development, 140, 3079-93. DOI ScienceOn |
2 | Kanthan R, Senger JL, Diudea D (2010), Malignant mixed Mullerian tumors of the uterus: histopathological evaluation of cell cycle and apoptotic regulatory proteins. World J Surg Oncol, 19, 8, 60. |
3 | Koehn FE, Carter GT (2005). The evolving role of natural products in drug discovery. Nat Rev Drug Discov, 4, 206-20. DOI ScienceOn |
4 | Ma L, Chen H, Dong P, Lu X (2013). Anti-inflammatory and anticancer activities of extracts and compounds from the mushroom Inonotus obliquus. Food Chem, 139, 503-8. DOI ScienceOn |
5 | Mishra BB, Tiwari VK (2011). Natural products: An evolving role in future drug discovery. Eur J Med Chem, 46, 4769-807. DOI ScienceOn |
6 | Nakajima Y, Nishida H, Matsugo S, et al (2009). Cancer cell cytotoxicity of cxtracts and small phenolic compounds from chaga [Inonotus obliquus (persoon) Pilat]. J Med Food, 12, 501-7. DOI |
7 | Nakata T, Yamada T, Taji S, et al (2007). Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus. Bioorg Med Chem, 15, 257-64. DOI ScienceOn |
8 | Nomura M, Takahashi T, Uesugi A, et al (2008). Inotodiol, a lanostane triterpenoid, from Inonotus obliquus inhibits cell proliferation through caspase-3-dependent apoptosis. Anticancer Res, 28, 2691-6. |
9 | Pachon G, Rasoanaivo H, Azqueta A, et al (2007). Anticancer effect of a new benzophenanthridine isolated from Zanthoxylum madagascariense (Rutaceline). In Vivo, 21, 417-22. |
10 | Chung MJ, Chung C-K, Jeong Y, et al (2010). Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells. Nutr Res Pract, 4, 177-82. DOI |
11 | Chung MJ, Walker PA, Brown RW, et al (2005). Zinc-mediated gene expression offers protection against -induced cytotoxicity. Toxicol Appl Pharmacol, 205, 225-36. DOI ScienceOn |
12 | Darzynkiewicz Z, Bedner E, Smolewski P (2001). Flow cytometry in analysis of cell cycle and apoptosis. Semin Hematol, 38, 179-93. DOI ScienceOn |
13 | Ferlay J, Shin HR, Bray F, et al (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer, 127, 2893-917. DOI ScienceOn |
14 | Ham SS, Kim SH, Moon SY, et al (2009). Antimutagenic effects of subfractions of Chaga Mushroom (Inonotus obliquus) extract. Mutat Res, 672, 55-9. DOI ScienceOn |
15 | KahlosK (1987). Antitumor activity of some compounds and fractions from an n-hexane extract of Inonotus obliquus. Acta Pharm Fenn, 96, 33-40. |
16 | Ramachandran S, Kwon KY, Shin SJ, et al (2008). Cyclin-dependent kinase inhibitor p27Kip1 controls growth and cell cycle progression in human uterine leiomyoma. J Korean Med Sci, 23, 667-73. DOI ScienceOn |
17 | Zhong XH, Ren K, Lu SJ, et al (2009). Progress of research on Inonotus obliquus. Chin J Integr Med, 15, 156-60. DOI ScienceOn |
18 | Zhong XH, Wang LB, Sun DZ (2011). Effects of inotodiol extracts from inonotus obliquus on proliferation cycle and apoptotic gene of human lung adenocarcinoma cell line A549. Chin J Integr, 17, 218-23. DOI ScienceOn |
19 | Suryadinata R, Sadowski M, Steel R, et al (2011). Cyclin-dependent kinase-mediated phosphorylation of RBP1 and pRb promotes their dissociation to mediate release of the SAP30.mSin3.HDAC transcriptional repressor complex. J Biol Chem, 286, 5108-18. DOI ScienceOn |
20 | Slingerlad J, Pagano M (2000). Regulation of the CDK inhibitor p27 and its deregulation in cancer. J Cell Physiol, 183, 10-7. DOI |
21 | Song FQ, Liu Y, Kong XS, et al (2013). Progress on understanding the anticancer mechanisms of medicinal mushroom: Inonotus obliquus. Asian Pac J Cancer Prev, 14, 1571-8. 과학기술학회마을 DOI ScienceOn |
22 | van Meir H, Kenter GG, Burggraaf J, et al (2014). The need for improvement of the treatment of advanced and metastatic cervical cancer, the rationale for combined Chemo-immunotherapy. Anticancer Agents Med Chem, 14, 190-203. DOI |
23 | Vermeulen K, Van Bockstaele DR, Berneman ZN (2003). The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer. Cell Prolif, 36, 131-49. DOI ScienceOn |
24 | Youn MJ, Kim JK, Park SY, et al (2008). Chaga mushroom (Inonotus obliquus) induces arrest and apoptosis in human hepatoma HepG2 cells. World J Gastroenterol, 14, 511-7. DOI ScienceOn |
25 | Youn MJ, Kim JK, Park SY, et al (2009). Potential anticancer properties of the water extract of Inonotus obliquus by induction of apoptosis in melanoma B16-F10 cells. J Ethnopharmacol, 21, 221-8. |
26 | Zhao FQ, Piao HS (2006). Studies of anti-mutation active constituents from Inonotus obliquus. Chinese Traditional and Herbal Drugs, 37, 1777-80. |
27 | Zhao FQ, Yan L, Cui XH,et al (2012). Triterpenoids from Inonotus obliquus protect mice against oxidative damage induced by CCl4. Yao Xue Xue Bao, 47, 680-84. |
28 | Krajewski S, Krajewska M, Shabaik A, et al (1994). Immunohistochemical determination of in vivo distribution of Bax, adominant inhibitor of Bcl-2. Am J Pathol, 145, 1323-36. |