Browse > Article
http://dx.doi.org/10.7314/APJCP.2014.15.6.2857

The G801A Polymorphism in the CXCL12 Gene and Risk of Breast Carcinoma: Evidence from a Meta-Analysis Including 2,931 Subjects  

Xia, Yong (Department of Clinical Laboratory Medicine, the Third Affiliated Hospital of Guangzhou Medical University)
Guo, Xu-Guang (Department of Clinical Laboratory Medicine, the Third Affiliated Hospital of Guangzhou Medical University)
Ji, Tian-Xing (Department of Clinical Laboratory Medicine, the Third Affiliated Hospital of Guangzhou Medical University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.6, 2014 , pp. 2857-2861 More about this Journal
Abstract
More and more evidence indicates that the G801A polymorphism in the CXCL12 gene might be associated with susceptibility to breast carcinoma in humans being. However, individually published results have been inconsistent. The purpose of this meta-analysis was to investigate the association between the G801A polymorphism in the CXCL12 gene and breast carcinoma risk. A complete search strategy was done by the electronic databases including PubMed and Chinese Biomedical Literature Database. A meta-analysis including seven individual studies was carried out in order to explore the association between the G801A polymorphism in the CXCL12 gene polymorphisms and breast carcinoma. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals (95%CIs) between the G801A polymorphism in the CXCL12 gene and breast carcinoma risk were assessed by the random-effects model. A significant relationship between the G801A polymorphism in the CXCL12 gene and breast carcinoma was discovered in an allelic genetic model (OR: 1.214, 95%CI: 1.085-1.358, p=0.001), a homozygote model (OR: 1.663, 95%CI: 1.240-2.232, p=0.001), a heterozygote model (OR: 1.392, 95%CI: 1.190-1.629, p=0.000), a recessive genetic model (OR: 1.407, 95%CI: 1.060-1.868, p=0.018) and a dominant genetic model (OR: 1.427, 95%CI: 1.228-1.659, p=0.000). On sub-group analysis based on ethnicity, significance was observed between the European group and the mixed group. A significant relationship was found between the G801A polymorphism in the CXCL12 gene and breast carcinoma risk. Individuals with the A allele of the G801A polymorphism in the CXCL12 gene are under a higher risk for breast carcinoma.
Keywords
Breast carcinoma; breast cancer; meta-analysis; G810A; polymorphism; CXCL12;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Mantel N, Haenszel W (1959). Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 22, 719-48.
2 Zafiropoulos A, Crikas N, Passam AM, Spandidos DA (2004). Significant involvement of CCR2-64I and CXCL12-3a in the development of sporadic breast cancer. J Med Genet, 41,59.   DOI
3 Kontogianni P, Zambirinis CP, Theodoropoulos G, et al (2013). The impact of the stromal cell-derived factor-1-3'A and E-selectin S128R polymorphisms on breast cancer. Mol Biol Rep, 40, 43-50.   DOI   ScienceOn
4 Kruszyna L, Lianeri M, Rubis B, et al (2010). CXCL12-3' G801A polymorphism is not a risk factor for breast cancer. DNA Cell Biol, 29, 423-7.   DOI   ScienceOn
5 Lin GT, Tseng HF, Yang CH, et al (2009). Combinational polymorphisms of seven CXCL12-related genes are protective against breast cancer in Taiwan. OMICS, 13, 165-72.   DOI
6 Ma XY, Jin Y, Sun HM, et al (2012). CXCL12 G801A polymorphism contributes to cancer susceptibility: a metaanalysis. Cell Mol Biol, 58, 1702-8.
7 Razmkhah M, Doroudchi M, Ghayumi SM, et al (2005). Stromal cell-derived factor-1 (SDF-1) gene and susceptibility of Iranian patients with lung cancer. Lung Cancer, 49, 311-5.   DOI   ScienceOn
8 Razmkhah M, Talei AR, Doroudchi M, et al (2005). Stromal cell-derived factor-1 (SDF-1) alleles and susceptibility to breast carcinoma. Cancer Lett, 225, 261-6.   DOI   ScienceOn
9 Shen W, Cao X, Xi L, Deng L (2012). CXCL12 G801A polymorphism and breast cancer risk: a meta-analysis. Mol Biol Rep, 39, 2039-44.   DOI
10 Siegel R, Naishadham D, Jemal A (2013). Cancer statistics, 2013. CA Cancer J Clin, 63, 11-30.   DOI   ScienceOn
11 Stuck AE, Rubenstein LZ, Wieland D (1998). Bias in metaanalysis detected by a simple, graphical test. Asymmetry detected in funnel plot was probably due to true heterogeneity. BMJ, 316, 470-1.
12 Thakkinstian A, McElduff P, D'Este C, et al (2005). A method for meta-analysis of molecular association studies. Stat Med, 24, 1291-306.   DOI   ScienceOn
13 de Oliveira KB, Oda JM, Voltarelli JC, et al (2009). CXCL12 rs1801157 polymorphism in patients with breast cancer, Hodgkin's lymphoma, and non-Hodgkin's lymphoma. J Clin Lab Anal, 23, 387-93.   DOI   ScienceOn
14 Cochran WG (1968). The effectiveness of adjustment by subclassification in removing bias in observational studies. Biometrics, 24, 295-313.   DOI   ScienceOn
15 de Oliveira KB, Guembarovski RL, Guembarovski AM, et al (2013). CXCL12, CXCR4 and IFNgamma genes expression: implications for proinflammatory microenvironment of breast cancer. Clin Exp Med, 13, 211-9.   DOI   ScienceOn
16 de Oliveira KB, Guembarovski RL, Oda JM, et al (2011). CXCL12 rs1801157 polymorphism and expression in peripheral blood from breast cancer patients. Cytokine, 55, 260-5.   DOI   ScienceOn
17 Desantis C, Ma J, Bryan L, Jemal A (2014). Breast cancer statistics, 2013. CA Cancer J Clin, 64, 52-62.   DOI   ScienceOn
18 Dimberg J, Hugander A, Lofgren S, Wagsater D. (2007). Polymorphism and circulating levels of the chemokine CXCL12 in colorectal cancer patients. Int J Mol Med, 19, 11-5.
19 Donnelly TT, Khater AH, Al-Bader SB, et al (2013). Arab women's breast cancer screening practices: a literature review. Asian Pac J Cancer Prev, 14, 4519-28.   DOI   ScienceOn
20 Gong H, Tan M, Wang Y, et al (2012). The CXCL12 G801A polymorphism and cancer risk: evidence from 17 casecontrol studies. Gene, 509, 228-31.   DOI   ScienceOn
21 Hinton CV, Avraham S, Avraham HK (2010). Role of the CXCR4/CXCL12 signaling axis in breast cancer metastasis to the brain. Clin Exp Metastasis, 27, 97-105.   DOI
22 Hassan S, Baccarelli A, Salvucci O, and Basik M (2008). Plasma stromal cell-derived factor-1: host derived marker predictive of distant metastasis in breast cancer. Clin Cancer Res, 14, 446-54.   DOI   ScienceOn
23 Chuang LY, Chang HW, Lin MC, Yang CH (2012). Chaotic particle swarm optimization for detecting SNP-SNP interactions for CXCL12-related genes in breast cancer prevention. Eur J Cancer Prev, 21, 336-42.   DOI