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http://dx.doi.org/10.7314/APJCP.2014.15.6.2405

Plant Extracts and Plant-Derived Compounds: Promising Players in Countermeasure Strategy Against Radiological Exposure: A Review  

Kma, Lakhan (Cancer and Radiation Countermeasures Unit, Department of Biochemistry, North-Eastern Hill University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.6, 2014 , pp. 2405-2425 More about this Journal
Abstract
Radiation exposure leads to several pathophysiological conditions, including oxidative damage, inflammation and fibrosis, thereby affecting the survival of organisms. This review explores the radiation countermeasure properties of fourteen (14) plant extracts or plant-derived compounds against these cellular manifestations. It was aimed at evaluating the possible role of plants or its constituents in radiation countermeasure strategy. All the 14 plant extracts or compounds derived from it and considered in this review have shown some radioprotection in different in vivo, ex-vivo and or in vitro models of radiological injury. However, few have demonstrated advantages over the others. C. majus possessing antioxidant, anti-inflammatory and immunomodulatory effects appears to be promising in radioprotection. Its crude extracts as well as various alkaloids and flavonoids derived from it, have shown to enhance survival rate in irradiated mice. Similarly, curcumin with its antioxidant and the ability to ameliorate late effect of radiation exposure, combined with improvement in survival in experimental animal following irradiation, makes it another probable candidate against radiological injury. Furthermore, the extracts of P. hexandrum and P. kurroa in combine treatment regime, M. piperita, E. officinalis, A. sinensis, nutmeg, genistein and ginsan warrants further studies on their radioprotective potentials. However, one that has received a lot of attention is the dietary flaxseed. The scavenging ability against radiation-induced free radicals, prevention of radiation-induced lipid peroxidation, reduction in radiation cachexia, level of inflammatory cytokines and fibrosis, are some of the remarkable characteristics of flaxseed in animal models of radiation injury. While countering the harmful effects of radiation exposure, it has shown its ability to enhance survival rate in experimental animals. Further, flaxseed has been tested and found to be equally effective when administered before or after irradiation, and against low doses (${\leq}5Gy$) to the whole body or high doses (12-13.5 Gy) to the whole thorax. This is particularly relevant since apart from the possibility of using it in pre-conditioning regime in radiotherapy, it could also be used during nuclear plant leakage/accidents and radiological terrorism, which are not pre-determined scenarios. However, considering the infancy of the field of plant-based radioprotectors, all the above-mentioned plant extracts/plant-derived compounds deserves further stringent study in different models of radiation injury.
Keywords
Radiation; plant extracts; antioxidant; inflammation; fibrosis; radioprotection;
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Times Cited By KSCI : 9  (Citation Analysis)
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1 Hari Kumar KB, Sabu MC, Lima PS, Kuttan R (2004). Modulation of haematopoetic system and antioxidant enzymes by Emblica officinalis gaertn and its protective role against gamma-radiation induced damages in mice. J Radiat Res, 45, 549-5.   DOI   ScienceOn
2 Gorshkova I, Zhou T, Mathew B, et al (2012). Inhibition of serine palmitoyltransferase delays the onset of radiationinduced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression. J Lipid Res, 53, 1553-68.   DOI   ScienceOn
3 Goel HC, Prakash H, Ali A, Bala M (2007). Podophyllum hexandrum modulates gamma radiation-induced immunosuppression in Balb/c mice: implications in radioprotection. Mol Cell Biochem, 295, 93-3.   DOI
4 Goel HC, Prasad J, Singh S, et al (2002). Radioprotection by a herbal preparation of Hippophae rhamnoides, RH-3, against whole body lethal irradiation in mice. Phytomedicine, 9, 15-5.   DOI   ScienceOn
5 Goel HC, Salin CA, Prakash H (2003). Protection of jejunal crypts by RH-3 (a preparation of Hippophae rhamnoides) against lethal whole body gamma irradiation. Phytother Res, 17, 222-6.   DOI   ScienceOn
6 Grigoleit HG, Grigoleit P (2005). Pharmacology and preclinical pharmacokinetics of peppermint oil. Phytomedicine, 12, 612-6.   DOI   ScienceOn
7 Grinevich Y, Shalimov S, Bendyuh G, Zahriychuk O, Hodysh Y (2005). Effect of Ukrain on the growth and metastasizing of Lewis carcinoma in C57BL/6 mice. Drugs Exp Clin Res, 31, 59-70.
8 Gullett NP, Ruhul Amin AR, Bayraktar S, et al (2010). Cancer prevention with natural compounds. Semin Oncol, 37, 258-81.   DOI   ScienceOn
9 Gupta D, Arora R, Garg AP, Bala M, Goel HC (2004). Modification of radiation damage to mitochondrial system in vivo by Podophyllum hexandrum: mechanistic aspects. Mol Cell Biochem, 266, 65-77.   DOI   ScienceOn
10 Gandhi NM, Nair CK (2004). Radiation protection by diethyldithiocarbamate: protection of membrane and DNA in vitro and in vivo against gamma-radiation. J Radiat Res, 45, 175-0.   DOI   ScienceOn
11 Francois S, Mouiseddine M, Allenet-Lepage B, et al (2013). Human mesenchymal stem cells provide protection against radiation-induced liver injury by antioxidative process, vasculature protection, hepatocyte differentiation, and trophic effects. Biomed Res Int, 2013, 151679-97.
12 Fu Y, Wang Y, Du L, et al (2013). Resveratrol inhibits ionising irradiation-induced inflammation in MSCs by activating SIRT1 and limiting NLRP-3 inflammasome activation. Int J Mol Sci, 14, 14105-18.   DOI
13 Gagliano N, Moscheni C, Torri C, et al (2007). Ukrain modulates glial fibrillary acidic protein, but not connexin 43 expression, and induces apoptosis in human cultured glioblastoma cells. Anticancer Drugs, 18, 669-6.   DOI   ScienceOn
14 Gao F, Fish BL, Szabo A, et al (2012). Short-term treatment with a SOD/catalase mimetic, EUK-207, mitigates pneumonitis and fibrosis after single-dose total-body or whole-thoracic irradiation. Radiat Res, 178, 468-80.   DOI
15 Gilca M, Gaman L, Stoian EPI, Atanasiu V (2010). Chelidonium majus-an integrative review: traditional knowledge versus modern findings. Forsch Komplementmed, 17, 241-8.   DOI   ScienceOn
16 Goel HC, Indraghanti P, Samanta N, Ranaz SV (2004). Induction of apoptosis in thymocytes by Hippophae rhamnoides: implications in radioprotection. J Environ Pathol Toxicol Oncol, 23, 123-37.   DOI
17 Goel HC, Kumar IP, Samanta N, Rana SV (2003). Induction of DNA-protein cross-links by Hippophae rhamnoides: implications in radioprotectionand cytotoxicity. Mol Cell Biochem, 245, 57-7.   DOI   ScienceOn
18 Day RM, Barshishat-Kupper M, Mog SR, et al (2008). Genistein protects against biomarkers of delayed lung sequelae in mice surviving high-dose total body irradiation. J Radiat Res, 49, 361-72.   DOI   ScienceOn
19 Dupasquier CM, Dibrov E, Kneesh AL, et al (2007). Dietary flaxseed inhibits atherosclerosis in the LDL receptordeficient mouse in part through antiproliferative and antiinflammatory actions. Am J Physiol Heart Circ Physiol, 293, 2394-2.   DOI   ScienceOn
20 Day RM, Davis TA, Barshishat-Kupper M, et al (2013). Enhanced hematopoietic protection from radiation by the combination of genistein and captopril. Int Immunopharmacol, 15, 348-6.   DOI   ScienceOn
21 Ding NH, Li JJ, Sun LQ (2013). Molecular mechanisms and treatment of radiation-induced lung fibrosis. Curr Drug Targets, 14, 1347-6.   DOI
22 Dutta A, Verma S, Sankhwar S, Flora SJ, Gupta ML (2012). Bioavailability, antioxidant and non toxic properties of a radioprotective formulation prepared from isolated compounds of Podophyllum hexandrum: a study in mouse model. Cell Mol Biol, 58, 1646-3.
23 Eklund PC, Langvik OK, Warna JP, et al (2005). Chemical studies on antioxidant mechanism and free radical scavenging properties of Lignans. Org Biomol Chem, 3, 3336-47.   DOI   ScienceOn
24 Flechsig P, Hartenstein B, Teurich S, et al (2010). Loss of matrix metalloproteinase-13 attenuates murine radiation-induced pulmonary fibrosis. Int J Radiat Oncol Biol Phys, 77, 582-0.   DOI   ScienceOn
25 Fleckenstein K, Gauter-Fleckenstein B, Jackson IL, et al (2007). Using biological markers to predict risk of radiation injury. Semin Radiat Oncol, 17, 89-8.   DOI   ScienceOn
26 Rodemann HP, Blaese MA (2007). Responses of normal cells to ionizing radiation. Semin Radiat Oncol, 17, 81-8.   DOI   ScienceOn
27 Roy SK, Agrahari UC, Gautam R, Srivastava A, Jachak SM (2012). Isointricatinol, a new antioxidant homoisoflavonoid from the roots of Caesalpinia digyna rottler. Nat Prod Res, 26, 690-5.   DOI   ScienceOn
28 Reboul FL (2004). Radiotherapy and chemotherapy in locally advanced non-small cell lung cancer: preclinical and early clinical data. Hematol Oncol Clin North Am, 18, 41-3.   DOI   ScienceOn
29 Regenbrecht CR, Jung M, Lehrach H, Adjaye J (2008). The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines. BMC Med Genomics, 1, 49-64.   DOI   ScienceOn
30 Fliedner TM, Dorr DH, Meineke V (2005). Multi-organ involvement as a pathogenetic principle of the radiation syndromes: a study involving 110 case histories documented in SEARCH and classified as the bases of haematopoietic indicators of effect. Br J Radiol Suppl, 27, 1-8.
31 Claro S, Kanashiro CA, Oshiro ME, Ferreira AT, Khalil RA (2007). Alpha-and epsilon-protein kinase C activity during smooth muscle cell apoptosis in response to gammaradiation. J Pharmacol Exp Ther, 322, 964-2.   DOI   ScienceOn
32 Christofidou-Solomidou M, Tyagi S, Pietrofesa R, et al (2012). Radioprotective role in lung of the flaxseed lignan complex enriched in the phenolic secoisolariciresinol diglucoside (SDG). Radiat Res, 178, 568-80.   DOI
33 Christofidou-Solomidou M, Tyagi S, Tan KS, et al (2011). Dietary flaxseed administered post thoracic radiation treatment improves survival and mitigates radiation-induced pneumonopathy in mice. BMC Cancer, 11, 269-83.   DOI
34 Citrin D, Cotrim AP, Hyodo F, et al (2010). Radioprotectors and mitigators of radiation-induced normal tissue injury. Oncologist, 15, 360-71.   DOI   ScienceOn
35 Copp RR, Peebles DD, Soref CM, Fahl WE (2013). Radioprotective efficacy and toxicity of a new family of aminothiol analogs. Int J Radiat Biol, 89, 485-2.   DOI   ScienceOn
36 Cordes N, Plasswilm L, Bamberg M, Rodemann HP (2002). Ukrain, an alkaloid thiophosphoric acid derivative of Chelidonium majus L. protects human fibroblasts but not human tumour cells in vitro against ionizing radiation. Int J Radiat Biol, 78, 17-7.   DOI
37 CrMErs P, Verhoeven EE, Filon AR, et al (2011). Impaired repair of ionizing radiation-induced DNA damage in Cockayne syndrome cells. Radiat Res, 175, 432-43.   DOI   ScienceOn
38 Samanta N, Kannan K, Bala M, Goel HC (2004). Radioprotective mechanism of Podophyllum hexandrum during spermatogenesis. Mol Cell Biochem, 267, 167-6.   DOI   ScienceOn
39 Saarinen NM, Power K, Chen J, Thompson LU (2006). Flaxseed attenuates the tumor growth stimulating effect of soy protein in ovariectomized athymic mice with MCF-7 human breast cancer xenografts. Int J Cancer, 119, 925-1.   DOI   ScienceOn
40 Saglam H, Arar G (2003). Cytotoxic activity and quality control determinations on Chelidonium majus. Fitoterapia, 74, 127-9.   DOI   ScienceOn
41 Samarth RM (2007). Protection against radiation induced hematopoietic damage in bone marrow of Swiss albino mice by Mentha piperita (Linn). J Rad Res, 48, 523-8.   DOI   ScienceOn
42 Samarth RM, Goyal PK, Kumar A (2004). Protection of Swiss albino mice against whole-body gamma irradiation by Mentha piperita (Linn.). Phytother Res, 18, 546-0.   DOI   ScienceOn
43 Samarth RM, Kumar A (2003). Radioprotection of Swiss albino mice by plant extract Mentha piperita (Linn.). J Radiat Res, 44, 101-9.   DOI   ScienceOn
44 Rajesh A, Sagar R, Singh S, et al (2007). Cytoprotective effect of Podophyllum hexandrum against gamma radiation is mediated via hemopoietic system stimulation and up-regulation of heme-oxygenase-1 and the prosurvival multidomain protein Bcl-2. Integr Cancer Ther, 6, 54-65.   DOI
45 Prouillac C, Vicendo P, Garrigues JC, Poteau R, Rima G (2009). Evaluation of new thiadiazoles and benzothiazoles as potential radioprotectors: free radical scavenging activity In vitro and theoretical studies (QSAR, DFT). Free Radic Biol Med, 46, 1139-8.   DOI   ScienceOn
46 Qiu J, Li J, He TC (2011). Endothelial cell damage induces a blood-alveolus barrier breakdown in the development of radiation-induced lung injury. Asia Pac J Clin Oncol, 7, 392-8.   DOI   ScienceOn
47 Checker R, Chatterjee S, Sharma D, et al (2008). Immunomodulatory and radioprotective effects of lignans derived from fresh nutmeg mace (Myristica fragrans) in mammalian splenocytes. Int Immunopharmacol, 8, 661-9.   DOI   ScienceOn
48 Davis TA, Clarke TK, Mog SR, Landauer MR (2007). Subcutaneous administration of genistein prior to lethal irradiation supports multilineage, hematopoietic progenitor cell recovery and survival. Int J Radiat Biol, 83, 141-1.   DOI   ScienceOn
49 Davis TA, Mungunsukh O, Zins S, Day RM, Landauer MR (2008). Genistein induces radioprotection by hematopoietic stem cell quiescence. Int J Radiat Biol, 84, 713-26.   DOI   ScienceOn
50 Chen Y, Duan JA, Qian D, et al (2010). Assessment and comparison of immunoregulatory activity of four hydrosoluble fractions of AngelicA. sinensis in vitro on the peritoneal macrophages in ICR mice. Int Immunopharmacol, 10, 422-0.   DOI   ScienceOn
51 Chen B, Zhou X, Taghizadeh K, et al (2007). GC/MS methods to quantify the 2-deoxypentos-4-ulose and 3'-phosphoglycolate pathways of 4' oxidation of 2-deoxyribose in DNA: application to DNA damage produced by gamma radiation and bleomycin. Chem Res Toxicol, 20, 1701-8.   DOI   ScienceOn
52 Chen J, Saggar JK, Corey P, Thompson LU (2009). Flaxseed and pure secoisolariciresinol diglucoside, but not flaxseed hull, reduce human breast tumor growth (MCF-7) in athymic mice. J Nutr, 139, 2061-6.   DOI   ScienceOn
53 Chen Y, Okunieff P (2004). Radiation and third-generation chemotherapy. Hematol Oncol Clin North Am, 18, 55-80.   DOI   ScienceOn
54 Cheng J, Kondo K, Suzuki Y, et al (2003). Inhibitory effects of total flavones of Hippophae rhamnoides L. on thrombosis in mouse femoral artery and in vitro platelet aggregation. Life Sci, 72, 2263-1.   DOI   ScienceOn
55 Razi SS, Latif MJ, Li X, et al (2011). Dietary flaxseed protects against lung ischemia reperfusion injury via inhibition of apoptosis and inflammation in a murine model. J Surg Res, 171, 113-1.   DOI   ScienceOn
56 Qiu X, Aiken KJ, Chokas AL, Beachy DE, Nick HS (2008). Distinct functions of CCAAT enhancer-binding protein isoforms in the regulation of manganese superoxide dismutase during interleukin-1beta stimulation. J Biol Chem, 283, 25774-85.   DOI   ScienceOn
57 Rao BSS, Shanbhoge R, Upadhya D, et al (2006). Antioxidant, anticlastogenic and radioprotective effect of Coleus aromaticus on Chinese hamster fibroblast cells (V79) exposed to gamma radiation. Mutagenesis, 21, 237-2.   DOI   ScienceOn
58 Rastogi S, Coates PJ, Lorimore SA, Wright EG (2012). Bystander-type effects mediated by long-lived inflammatory signaling in irradiated bone marrow. Radiat Res, 177, 244-0.   DOI
59 Peebles DD, Soref CM, Copp RR, Thunberg AL, Fahl WE (2012). ROS-scavenger and radioprotective efficacy of the new PrC-210 aminothiol. Radiat Res, 178, 57-68.   DOI
60 Para AE, Bezjak A, Yeung IW, Van Dyk J, Hill RP ( 2009). Effects of genistein following fractionated lung irradiation in mice. Radiother Oncol, 92, 500-0.   DOI   ScienceOn
61 Parihar VK, Dhawan J, Kumar S, et al (2007). Free radical scavenging and radioprotective activity of dehydrozingerone against whole body gamma irradiation in Swiss albino mice. Chem Biol Interact, 170, 49-8.   DOI   ScienceOn
62 Park E, Hwang I, Song JY, Jee Y (2011). Acidic polysaccharide of Panax ginseng as a defense against small intestinal damage by whole-body gamma irradiation of mice. Acta Histochem, 113, 19-3.   DOI   ScienceOn
63 Calveley VL, Jelveh S, Langan A, et al (2010). Genistein can mitigate the effect of radiation on rat lung tissue. Radiat Res, 173, 602-1.   DOI   ScienceOn
64 Chirathaworn C, Kongcharoensuntorn W, Dechdoungchan T, et al (2007). Myristica fragrans Houtt. methanolic extract induces apoptosis in a human leukemia cell line through SIRT1 mRNA downregulation. J Med Assoc Thai, 90, 2422-8.
65 Cho YJ, Yi CO, Jeon BT, et al (2013). Curcumin attenuates radiation-induced inflammation and fibrosis in rat lungs. Korean J Physiol Pharmacol, 17, 267-4.   DOI   ScienceOn
66 Choudhary GP (2009). Diuretic activity of the leaves of Coleus aromaticus Benth. Anc Sci Life, 29, 20-1.
67 Brown AP, Chung EJ, Urick ME, et al (2010). Evaluation of the fullerene compound DF-1 as a radiation protector. Radiat Oncol, 5, 34-46.   DOI   ScienceOn
68 Cahlikova L, Opletal L, Kurfurst M, et al (2010). Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Chelidonium majus (Papaveraceae). Nat Prod Commun, 5, 1751-4.
69 Cai HB, Luo RC (2003). Prevention and therapy of radiation induced pulmonary injury with traditional Chinese medicine. Di Yi Jun Yi Da Xue Xue Bao, 23, 958-0.
70 Cao W, Li XQ, Wang X, et al (2010a). Characterizations and anti-tumor activities of three acidic polysaccharides from AngelicA. sinensis (Oliv.) Diels. Int J Biol Macromol, 46, 115-2.   DOI   ScienceOn
71 Cao W, Li XQ, Wang X, et al (2010b). A novel polysaccharide, isolated from AngelicA. sinensis (Oliv.) Diels induces the apoptosis of cervical cancer hela cells through an intrinsic apoptotic pathway. Phytomedicine, 17, 598-5.   DOI   ScienceOn
72 Prakash H, Bala M, Ali A, Goel HC (2005). Modification of gamma radiation induced response of peritoneal macrophages and splenocytes by Hippophae rhamnoides (RH-3) in mice. J Pharm Pharmacol, 57, 1065-2.   DOI   ScienceOn
73 Piaru SP, Mahmud R, Abdul Majid AM, Mahmoud Nassar ZD (2012). Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia. Asian Pac J Trop Med, 5, 294-8.   DOI   ScienceOn
74 Pietrofesa R, Turowski J, Tyagi S, et al (2013). Radiation mitigating properties of the lignan component in flaxseed. BMC Cancer, 13, 179-96.   DOI
75 Pragya P, Shukla AK, Murthy RC, Abdin MZ, Kar Chowdhuri D (2014). Over-expression of superoxide dismutase meliorates Cr(vi) induced adverse effects via modulating cellular immune system of Drosophila melanogaster. PLoS One, 9, 88181-201.   DOI
76 Pritima RA, Pandian RS (2007). Antimicrobial activity of Coleus aromaticus (Benth) against microbes of reproductive tract infections among women. African J Infec Disease, 1, 18-2.
77 Nadova S, Miadokova E, Alfoldiova L, et al (2008). Potential antioxidant activity, cytotoxic and apoptosis-inducing effects of Chelidonium majus L. extract on leukemia cells. Neuro Endocrinol Lett, 29, 649-2.
78 Mukherjee D, Coates PJ, Lorimore SA, Wright EG (2012). The in vivo expression of radiation-induced chromosomal instability has an inflammatory mechanism. Radiat Res, 177, 18-4.   DOI
79 Mukherjee D, Coates PJ, Lorimore SA, Wright EG (2014). Responses to ionizing radiation mediated by inflammatory mechanisms. J Pathol, 232, 289-9.   DOI   ScienceOn
80 Multhoff G, Radons J (2012). Radiation, inflammation, and immune responses in cancer. Front Oncol, 2, 58-92.
81 Barg M, Rezin GT, Leffa DD, et al (2013). Evaluation of the protective effect of Ilex paraguariensis and CamelliA. sinensis extracts on the prevention of oxidative damage caused by ultraviolet radiation. Environ Toxicol Pharmacol, 37, 195-1.
82 Chawla R, Arora R, Kumar R, et al (2005). Antioxidant activity of fractionated extracts of rhizomes of high-altitude Podophyllum hexandrum: role in radiation protection. Mol Cell Biochem, 273, 193-08.   DOI
83 Chawla R, Arora R, Sagar RK, et al (2005). 3-O-beta-DGalactopyranoside of quercetin as an active principle from high altitude Podophyllum hexandrum and evaluation of its radioprotective properties. Z Naturforsch C, 60, 728-8.
84 Chawla R, Arora R, Singh S, et al (2006). Podophyllum hexandrum offers radioprotection by modulating free radical flux: role of aryl-tetralin lignans. Evid Based Complement Alternat Med, 3, 503-1.   DOI
85 Arora R, Gupta D, Chawla R, et al (2005). Radioprotection by plant products: present status and future prospects. Phytother Res, 19, 1-22.   DOI   ScienceOn
86 Baliga MS, Bhat HP, PereiramM, Mathias N, Venkatesh P (2010). Radioprotective effects of Aegle marmelos (L.) Correa (Bael): a concise review. J Altern Complement Med, 16, 1109-6.   DOI   ScienceOn
87 Baliga MS, Dsouza JJ (2011). Amla (Emblica officinalis Gaertn), a wonder berry in the treatment and prevention of cancer. Eur J Cancer Prev, 20, 225-39.   DOI   ScienceOn
88 Bergman Jungestrom M, Thompson LU, Dabrosin C (2007). Flaxseed and its lignans inhibit estradiol-induced growth, angiogenesis, and secretion of vascular endothelial growth factor in human breast cancer xenografts in vivo. Clin Cancer Res, 13, 1061-7.   DOI   ScienceOn
89 Nemavarkar P, Chourasia BK, Pasupathy K (2004). Evaluation of radioprotective action of compounds using Saccharomyces cerevisiae. J Environ Pathol Toxicol Oncol, 23, 145-1.   DOI
90 Nawrot R, Zauber H, Schulze WX (2014). Global proteomic analysis of Chelidonium majus and Corydalis cava (Papaveraceae) extracts revealed similar defense-related protein compositions. Fitoterapia, [Epub ahead of print].
91 Pal A, Pal AK (2005). Radioprotection of turmeric extracts in bacterial system. Acta Biol Hung, 56, 333-3.   DOI   ScienceOn
92 Pal S, Saha C, Dey SK (2013). Studies on black tea (CamelliA. sinensis) extract as a potential antioxidant and a probable radioprotector. Radiat Environ Biophys, 52, 269-8.   DOI   ScienceOn
93 Palombo EA (2006). Phytochemicals from traditional medicinal plants used in the treatment of diarrhoea: modes of action and effects on intestinal function. Phytother Res, 20, 717-4.   DOI   ScienceOn
94 Panganiban RA, Mungunsukh O, Day RM (2013). X-irradiation induces ER stress, apoptosis, and senescence in pulmonary artery endothelial cells. Int J Radiat Biol, 1, 656-67.
95 Mehta V (2005). Radiation pneumonitis and pulmonary fibrosis in non-small-cell lung cancer: pulmonary function, prediction, and prevention. Int J Radiat Oncol Biol Phys, 63, 5-24.   DOI   ScienceOn
96 Madan B, Ghosh B (2003). Diferuloylmethane inhibits neutrophil infiltration and improves survival of mice in high-dose endotoxin shock. Shock, 19, 91-6.
97 McCurdy M, Bergsma DP, Hyun E, et al (2013). The role of lung lobes in radiation pneumonitis and radiation-induced inflammation in the lung: a retrospective study. J Radiat Oncol, 2, 203-8.   DOI   ScienceOn
98 Bouvard V, Zaitchouk T, Vacher M, et al (2000). Tissue and cellspecific expression of the p53-target genes: bax, fas, mdm2 and waf1/p21, before and following ionising irradiation in mice. Oncogene, 19, 649-60.   DOI
99 Bing SJ, Kim MJ, Ahn G, et al (2013). Acidic polysaccharide of Panax ginseng regulates the mitochondria/caspasedependent apoptotic pathway in radiation-induced damage to the jejunum in mice. Acta Histochem, [Epub ahead of print].
100 Biswas SJ, Bhattacharjee N, Khuda-Bukhsh AR (2008). Efficacy of a plant extract (Chelidonium majus L.) in combating induced hepatocarcinogenesis in mice. Food Chem Toxicol, 46, 1474-87.   DOI   ScienceOn
101 Brand RM, Jendrzejewski JL (2008). Topical treatment with -epigallocatechin-3-gallate and genistein after a single UV exposure can reduce skin damage. J Dermatol Sci, 50, 69-2.   DOI   ScienceOn
102 Alok A, Adhikari JS, Chaudhury NK (2013). Radioprotective role of clinical drug diclofenac sodium. Mutat Res, 755, 156-2.   DOI   ScienceOn
103 Agrawala PK, Adhikari JS (2009). Modulation of radiationinduced cytotoxicity in U 87 cells by RH-3 (a preparation of Hippophae rhamnoides). Indian J Med Res, 130, 542-9.
104 Agrawala PK, Goel HC (2002). Protective effect of RH-3 with special reference to radiation induced micronuclei in mouse bone marrow. Indian J Exp Biol, 40, 525-0.
105 Akinboro A, Mohmed KB, Asmawi MZ, Sulaiman SF, Sofiman OA (2011). Antioxidants in aqueous extract of Myristica fragrans (Houtt.) suppress mitosis and cyclophosphamideinduced chromosomal aberrations in Allium cepa L cells. J Zhejiang Univ Sci B, 12, 915-2.   DOI   ScienceOn
106 Alves JG, de Brito Rde C, Cavalcanti TS (2012). Effectiveness of Mentha piperita in the treatment of infantile colic: a crossover study. Evid Based Complement Alternat Med, 2012, 981352-7.
107 Monceau V, Meziani L, Strup-Perrot C, et al (2013). Enhanced sensitivity to low dose irradiation of ApoE-/- mice mediated by early pro-inflammatory profile and delayed activation of the TGF$\beta$1 cascade involved in fibrogenesis. PLoS One, 8, 57052-66.   DOI
108 McFarland HI, Puig M, Grajkowska LT, et al (2012). Regulatory T cells in $\gamma$-irradiation-induced immune suppression. PLoS One, 7, 39092-2.   DOI
109 Mikhailenko VM, Diomina EA, Muzalov II, Gerashchenko BI (2013). Nitric oxide coordinates development of genomic instability in realization of combined effect with ionizing radiation. Exp Oncol, 35, 58-4.
110 Mitra SK, Kannan R, Sundaram R (2007). Pharmacognostical and physicochemical characteristics of roots of lesser known medicinal plant Caesalpinia digyna rottl. Anc Sci Life, 26, 35-9.
111 Moore ED, Kooshki M, Metheny-Barlow LJ, Gallagher PE, Robbins ME (2013). Angiotensin-(1-7) prevents radiationinduced inflammation in rat primary astrocytes through regulation of MAP kinase signaling. Free Radic Biol Med, 65, 1060-8.   DOI   ScienceOn
112 Morita T, Jinno K, Kawagishi H, et al (2003). Hepatoprotective effect of Myristicin from Nutmeg (Myristica fragrans) on lipopolysaccharide/D-galactosamine-induced liver injury. J Agric Food Chem, 51, 15605.
113 Lindahl G, Saarinen N, Abrahamsson A, Dabrosin C (2011). Tamoxifen, flaxseed, and the lignan enterolactone increase stroma- and cancer cell-derived IL-1Ra and decrease tumor angiogenesis in estrogen-dependent breast cancer. Cancer Res, 71, 51-0.
114 Lee YC, Kim SH, Roh SS, Choi HY, Seo YB (2007). Suppressive effects of Chelidonium majus methanol extract in knee joint, regional lymph nodes, and spleen on collagen-induced arthritis in mice. J Ethnopharmacol, 112, 40-8.   DOI   ScienceOn
115 Arora R, Chawla R, Puri SC, et al (2005). Radioprotective and antioxidant properties of low-altitude Podophyllum hexandrum (LAPH). J Environ Pathol Toxicol Oncol, 24, 299-14.   DOI   ScienceOn
116 Anand P, Thomas SG, Kunnumakkara AB, et al (2008). Biological activities of curcumin and its analogues (congeners) made by man and mother nature. Biochem Pharmacol, 76, 1590-11.   DOI   ScienceOn
117 Aravindan N, Madhusoodhanan R, Ahmad S, Johnson D, Herman TS (2008). Curcumin inhibits NF-kappaB mediated radioprotection and modulate apoptosis related genes in human neuroblastoma cells. Cancer Biol Ther, 7, 569-6.
118 Arora R, Chawla R, Dhaker AS, et al (2010). Podophyllum hexandrum as a potential botanical supplement for the medical management of nuclear and radiological emergencies (NREs) and free radical-mediated ailments: leads from In vitro/in vivo radioprotective efficacy evaluation. J Diet Suppl, 7, 31-50.   DOI   ScienceOn
119 Adil MD, Kaiser P, Satti NK, et al (2010). Effect of Emblica officinalis (fruit) against UVB-induced photo-aging in human skin fibroblasts. J Ethnopharmacol, 132, 109-4.   DOI   ScienceOn
120 Zhang Z, Guo Y, Wei X (2011). Screen for natural benzylisoquinoline alkaloids against tumor. Zhongguo Zhong Yao Za Zhi, 36, 2684-8.
121 Zhang P, Mao YC, Sun B, Qian M, Qu WJ (2005). Changes in apoptosis-related genes expression profile in human breast carcinoma cell line Bcap-37 induced by flavonoids from seed residues of Hippophae rhamnoides L. Ai Zheng, 24, 454-0.
122 Zhang S, He B, Ge J, et al (2010). Extraction, chemical analysis of AngelicA. sinensis polysaccharides and antioxidant activity of the polysaccharides in ischemia-reperfusion rats. Int J Biol Macromol, 47, 546-0.   DOI   ScienceOn
123 Liu C, Li J, Meng FY, et al (2010). Polysaccharides from the root of AngelicA. sinensis promotes hematopoiesis and thrombopoiesis through the PI3K/AKT pathway. BMC Complement Altern Med, 10, 79-93.   DOI   ScienceOn
124 Li XL, Yao JY, Zhou ZM, et al (2011). Activity of the chelerythrine, a quaternary benzo[c]phenanthridine alkaloid from Chelidonium majus L. on Dactylogyrus intermedius. Parasitol Res, 109, 247-2.   DOI   ScienceOn
125 Linard C, Marquette C, Mathieu J, et al (2004). Acute induction of inflammatory cytokine expression after gamma-irradiation in the rat: effect of an NF-kB inhibitor. Int J Radiat Oncol Biol Phys, 58, 427-4.   DOI   ScienceOn
126 Little JB (2000). Radiation carcinogenesis. Carcinogenesis, 21, 397-4.   DOI   ScienceOn
127 Liu LN, Guo ZW, Zhang Y, Qin H, Han Y (2012). Polysaccharide extracted from Rheum tanguticum prevents irradiationinduced immune damage in mice.. Asian Pac J Cancer Prev, 13, 4101-5.   DOI   ScienceOn
128 Luksa-Lichtenthaeler GL, Ladutko EI, Nowicky JW (2000). Radiomodification effects of Ukrain, a cytostatic and immunomodulating drug, on intracellular glucocorticoid reception during short-term gamma-irradiation. Drugs Exp Clin Res, 26, 311-5.
129 Machtay M, Scherpereel A, Santiago J, et al (2006). Systemic polyethylene glycol-modified (PE Gylated) superoxide dismutase and catalase mixture attenuates radiation pulmonary fibrosis in the C57/bl6 mouse. Radiother Oncol, 81, 196-5.   DOI   ScienceOn
130 Lanvers-Kaminsky C, Nolting DM, Koster J, et al (2006). Invitro toxicity of Ukrain against human Ewing tumor cell lines. Anticancer Drugs, 17, 1025-0.   DOI   ScienceOn
131 Zuo GY, Meng FY, Hao XY, et al (2008). Antibacterial alkaloids from Chelidonium majus L (papaveraceae) against clinical isolates of methicillin-resistant Staphylococcus aureus. J Pharm Pharm Sci, 11, 90-4.
132 Zhang Y, Zhu G, Gu S, et al (2010). Genistein inhibits osteolytic bone metastasis and enhances bone mineral in nude mice. Environ Toxicol Pharmacol, 30, 37-4.   DOI   ScienceOn
133 Zhao L, Wang Y, Shen HL, et al (2012). Structural characterization and radioprotection of bone marrow hematopoiesis of two novel polysaccharides from the root of AngelicA. sinensis (Oliv.) diels. Fitoterapia, 83, 1712-0.   DOI   ScienceOn
134 Zhou Y, Mi MT (2005). Genistein stimulates hematopoiesis and increases survival in irradiated mice. J Radiat Res, 46, 425-3.   DOI   ScienceOn
135 Yao JY, Zhou ZM, Pan XY, et al (2011). In vivo anthelmintic activity of chelidonine from Chelidonium majus L. against Dactylogyrus intermedius in carassius auratus. Parasitol Res, 109, 1465-9.   DOI   ScienceOn
136 Yang T, Jia M, Meng J, Wu H, Mei Q (2006). Immunomodulatory activity of polysaccharide isolated from AngelicA. sinensis. Int J Biol Macromol, 39, 179-4.   DOI   ScienceOn
137 Yang T, Jia M, Zhou S, Pan F, Mei Q (2012). Antivirus and immune enhancement activities of sulfated polysaccharide from AngelicA. sinensis. Int J Biol Macromol, 50, 768-2.   DOI   ScienceOn
138 Yu H, Zheng L, Yin L, et al (2014). Protective effects of the total saponins from Dioscorea nipponica makino against carbon tetrachloride-induced liver injury in mice through suppression of apoptosis and inflammation. Int Immunopharmacol, [Epub ahead of print].
139 Zeb A (2004). Important therapeutic uses of sea buckthorn (Hippophae), J Biol Sci, 4, 687-3.   DOI
140 Kunwar A, Narang H, Priyadarsini KI, et al (2007). Delayed activation of PKCdelta and NF-kappaB and higher radioprotection in splenic lymphocytes by copper (II)- Curcumin (1:1) complex as compared to curcumin. J Cell Biochem, 102, 1214-4.   DOI   ScienceOn
141 Lachumy SJ, Oon CE, Deivanai S, et al (2013). Herbal remedies for combating irradiation: a green anti- irradiation approach. Asian Pac J Cancer Prev, 14, 5553-65.   DOI   ScienceOn
142 Lans C (2007). Ethnomedicines used in Trinidad and Tobago for reproductive problems. J Ethnobiol Ethnomed, 15, 3-3.
143 Lata M, Prasad J, Singh S, et al (2009). Whole body protection against lethal ionizing radiation in mice by REC-2001: a semi-purified fraction of Podophyllum hexandrum. Phytomedicine, 16, 47-5.   DOI   ScienceOn
144 Lee JC, Kinniry PA, Arguiri E, et al (2010). Dietary curcumin increases antioxidant defenses in lung, ameliorates radiationinduced pulmonary fibrosis, and improves survival in mice. Radiat Res, 173, 590-01.   DOI   ScienceOn
145 Lee JC, Bhora F, Sun J, et al (2008). Dietary flaxseed enhances antioxidant defenses and is protective in a mouse model of lung ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol, 294, 255-5.
146 Lee JC, Krochak R, Blouin A, et al (2009). Dietary flaxseed prevents radiation-induced oxidative lung damage, inflammation and fibrosis in a mouse model of thoracic radiation injury. Cancer Biol Ther, 8, 47-3.   DOI
147 Lee JG, Hsieh WT, Chen SU, Chiang BH (2012). Hematopoietic and myeloprotective activities of an acidic AngelicA. sinensis polysaccharide on human CD34+stem cells. J Ethnopharmacol, 139, 739-5.   DOI   ScienceOn
148 Zhang LY, Wang XL, Sun DX, et al (2008). Regulation of zinc transporters by dietary flaxseed lignan in human breast cancer xenografts. Mol Biol Rep, 35, 595-0.   DOI
149 Zemskov V, Prokopchuk O, Susak Y, et al (2002). Efficacy of ukrain in the treatment of pancreatic cancer. Langenbecks Arch Surg, 387, 84-9.   DOI   ScienceOn
150 Zhang C, Qi X, Shi Y, et al (2012). Estimation of trace elements in mace (Myristica fragrans houtt) and their effect on uterine cervix cancer induced by methylcholanthrene. Biol Trace Elem Res, 149, 431-4.   DOI   ScienceOn
151 Wang J, Xu HW, Li BS, Zhang J, Cheng J (2012). Preliminary study of protective effects of flavonoids against radiationinduced lung injury in mice. Asian Pac J Cancer Prev, 13, 6441-6.   DOI   ScienceOn
152 Uglyanitsa KN, Nefyodov LI, Doroshenko YM, et al (2000). Ukrain: a novel antitumor drug. Review. Drugs Exp Clin Res, 26, 341-56.
153 Upadhyay D, Dash RP, Anandjiwala S, Nivsarkar M (2013). comparative pharmacokinetic profiles of picrosides I and II from kutkin, Picrorhiza kurroa extract and its formulation in rats. Fitoterapia, 85, 76-3.   DOI   ScienceOn
154 Vijayavel K, Anbuselvam C, Ashokkumar B (2013). Protective effect of Coleus aromaticus benth (Lamiaceae) against naphthalene-induced hepatotoxicity. Biomed Environ Sci, 26, 295-2.
155 Wang L, Chen J, Thompson LU (2005). The inhibitory effect of flaxseed on the growth and metastasis of estrogen receptor negative human breast cancer xenograftsis attributed to both its lignan and oil components. Int J Cancer, 116, 793-8.   DOI   ScienceOn
156 Wang YN, Wu W, Chen HC, Fang H (2010). Genistein protects against UVB-induced senescence-like characteristics in human dermal fibroblast by p66Shc down-regulation. J Dermatol Sci, 58, 19-7.   DOI   ScienceOn
157 Krishnaveni M, Mirunalini S (2010). Therapeutic potential of Phyllanthus emblica (amla): the ayurvedic wonder. Review. J Basic Clin Physiol Pharmacol, 21, 93-105.
158 Kuenzel J, Geisler K, Strahl O, et al (2013). Chelidonium majus and its effects on uterine contractility in a perfusion model. Eur J Obstet Gynecol Reprod Biol, 169, 213-7.   DOI   ScienceOn
159 Koriem KM, Arbid MS, Asaad GF (2013). Chelidonium majus leaves methanol extract and its chelidonine alkaloid ingredient reduce cadmium-induced nephrotoxicity in rats. J Nat Med, 67, 159-7.   DOI   ScienceOn
160 Korolenko TA, Poteryaeva ON, Djanayeva SJ, et al (2000). Cystatin C in LS lymphosarcoma and HA-1 hepatoma treated with Ukrain and cyclophosphamide and involvement of apoptosis. Drugs Exp Clin Res, 26, 285-2.
161 Kucuktulu E (2012). Protective effect of melatonin against radiation induced nephrotoxicity in rats. Asian Pac J Cancer Prev, 13, 4101-5.   DOI   ScienceOn
162 Kulp M, Bragina O, Kogerman P, Kaljurand M (2011). Capillary electrophoresis with LED-induced native fluorescence detection for determination of isoquinoline alkaloids and their cytotoxicity in extracts of Chelidonium majus L. J Chromatogr A, 1218, 5298-4.   DOI   ScienceOn
163 Kumar IP, Namita S, Goel HC (2002). Modulation of chromatin organization by RH-3, a preparation of Hippophae rhamnoides, a possible role in radioprotection. Mol Cell Biochem, 238, 1-9.   DOI   ScienceOn
164 Kumar R, Singh PK, Sharma A, et al (2005). Podophyllum hexandrum (Himalayan mayapple) extract provides radioprotection by modulating the expression of proteins associated with apoptosis. Biotechnol Appl Biochem, 42, 81-92.   DOI   ScienceOn
165 Talhouk RS, Karam C, Fostok S, El-Jouni W, Barbour EK (2007). Anti-inflammatory bioactivities in plant extracts. Review. J Med Food, 10, 1-10.   DOI   ScienceOn
166 Wang ZD, Qiao YL, Tian XF, et al (2012). Toll-like receptor 5 agonism protects mice from radiation pneumonitis and pulmonary fibrosis. Asian Pac J Cancer Prev, 13, 4763-7.   DOI
167 Weiss JF, Landauer MR (2003). Protection against ionizing radiation by antioxidant nutrients and phytochemicals. Toxicology, 189, 1-20.   DOI   ScienceOn
168 Xie CH, Zhang MS, Zhou YF, et al (2006). Chinese medicine AngelicA. sinensis suppresses radiation-induced expression of TNF-alpha and TGF-beta1 in mice. Oncol Rep, 15, 1429-6.
169 Sureshbabu AV, Barik TK, Namita I, Prem Kumar I (2008). Radioprotective properties of Hippophae rhamnoides (sea buckthorn) extract in vitro. Int J Health Sci, 2, 45-62.
170 Swarts SG, Gilbert DC, Sharma KK, et al (2007). Mechanisms of direct radiation damage in DNA, based on a study of the yields of base damage, deoxyribose damage, and trapped radicals in d(GCACGCGTGC)(2). Radiat Res, 168, 367-81.   DOI
171 Tajuddin, Ahmad S, Latif A, Qasmi IA, Amin KM (2005). An experimental study of sexual function improving effect of Myristica fragrans Houtt. (nutmeg). BMC Complement Altern Med, 5, 16-6.   DOI   ScienceOn
172 Tayarani-Najaran Z, Talasaz-Firoozi E, Nasiri R, Jalali N, Hassanzadeh M (2013). Antiemetic activity of volatile oil from Mentha spicata and Mentha piperita in chemotherapyinduced nausea and vomiting. Ecancermedicalscience, 7, 290-5.
173 Thotala D, Chetyrkin S, Hudson B, et al (2009). Pyridoxamine protects intestinal epithelium from ionizing radiationinduced apoptosis. Free Radic Biol Med, 47, 779-5.   DOI
174 Kasem RF, Hegazy RH, Arafa MA, Abdelmohsenm M (2014). Chemopreventive effect of Mentha piperita on dimethylbenz[a]anthracene and formaldehydeinduced tongue carcinogenesis in mice (histological and immunohistochemical study). J Oral Pathol Med, [Epub ahead of print].
175 Kim HJ, Kim MH, Byon YY, et al (2007). Radioprotective effects of an acidic polysaccharide of Panax ginseng on bone marrow cells. J Vet Sci, 8, 39-4.   DOI   ScienceOn
176 Jindal A, Soyal D, Sharma A, Goyal PK (2009). Protective effect of an extract of Emblica officinalis against radiation-induced damage in mice. Integr Cancer Ther, 8, 98-5.   DOI
177 Kapoor S (2013). Ukrain and its emerging role as an antineoplastic agent in systemic malignancies. Exp Oncol, 35, 127-2.
178 Kim SH, Lee SE, Oh H, et al (2002). The radioprotective effects of buzhong-yi-qi-tang: a prescription of traditional Chinese medicine. Am J Chin Med, 30, 127-7.   DOI   ScienceOn
179 Kinniry P, Amrani Y, Vachani A, et al (2006). Dietary flaxseed supplementation ameliorates inflammation and oxidative tissue damage in experimental models of acute lung injury in mice. J Nutr, 136, 1545-1.
180 Kitagawa S, Inoue K, Teraoka R, Morita SY (2010). Enhanced skin delivery of genistein and other two isoflavones by microemulsion and prevention against UV irradiationinduced erythema formation. Chem Pharm Bull, 58, 398-1.   DOI   ScienceOn
181 Kma L, Gao F, Fish BL, et al (2012). Angiotensin converting enzyme inhibitors mitigate collagen synthesis induced by a single dose of radiation to the whole thorax. J Radiat Res, 53, 10-7.   DOI
182 Kong FM, Ten Haken R, Eisbruch A, Lawrence TS (2005). Non-small cell lung cancer therapy-related pulmonary toxicity: an update on radiation pneumonitis and fibrosis. Semin Oncol, 32, S42-4.
183 Singh U, Kunwar A, Srinivasan R, Nanjan MJ, Priyadarsini IK (2009). Differential free radical scavenging activity and radioprotection of Caesalpinia digyna extracts and its active constituent. J Radiat Res, 50, 425-3.   DOI   ScienceOn
184 Thuong PT, Hung TM, Khoi NM, et al (2013). Cytotoxic and anti-tumor activities of lignans from the seeds of Vietnamese nutmeg Myristica fragrans. Arch Pharm Res, [Epub ahead of print].
185 Tiwari SS, PandeymM, Srivastava S, Rawat AK (2012). TLC densitometric quantification of picrosides (picroside-I and picroside-II) in Picrorhiza kurroa and its substitute Picrorhiza scrophulariiflora and their antioxidant studies. Biomed Chromatogr, 26, 61-8.   DOI
186 Tokalov SV, Abramyuk AM, Abolmaali ND (2010). Protection of p53 wild type cells from taxol by genistein in the combined treatment of lung cancer. Nutr Cancer, 62, 795-1.   DOI
187 Shuryak I, Brenner DJ (2010). Effects of radiation quality on interactions between oxidative stress, protein and DNA damage in Deinococcus radiodurans. Radiat Environ Biophys, 49, 693-3.   DOI
188 Si HY, Li DP, Wang TM, et al (2010). Improving the anti-tumor effect of genistein with a biocompatible superparamagnetic drug delivery system. J Nanosci Nanotechnol, 10, 2325-1.   DOI
189 Singh I, Sharma A, Nunia V, Goyal PK (2005). Radioprotection of Swiss albino mice by Emblica officinalis. Phytother Res, 19, 444-6.   DOI
190 Son TG, Gong EJ, Bae MJ, et al (2013). Protective effect of genistein on radiation-induced intestinal injury in tumor bearing mice. BMC Complement Altern Med, 13, 103-14.   DOI
191 Song JY, Yang HO, Shim JY, et al (2003). Radiation protective effect of an extract from Chelidonium majus. Int J Hematol, 78, 226-2.   DOI   ScienceOn
192 Jagetia GC, Venkatesh P, Baliga MS (2004a). Evaluation of the radioprotective effect of bael leaf (Aegle marmelos) extract in mice. Int J Radiat Biol, 80, 281-0.   DOI   ScienceOn
193 Jagetia GC, Venkatesh P, Baliga MS (2004b). Fruit extract of Aegle marmelos protects mice against radiation-induced lethality. Integr Cancer Ther, 3, 323-2.   DOI
194 Jagetia GC, Venkatesh P, Archana P, Krishnanand BR, Baliga MS (2006). Effects of Aegle marmelos (L.) Correa on the peripheral blood and small intestine of mice exposed to gamma radiation. J Environ Pathol Toxicol Oncol, 25, 611-24.   DOI
195 Jagetia GC, Venkatesh P, Baliga MS (2003). Evaluation of the radioprotective effect of Aegle marmelos (L.) correa in cultured human peripheral blood lymphocytes exposed to different doses of $\gamma$-radiation: a micronucleus study. Mutagenesis, 18, 387-3.   DOI   ScienceOn
196 Janko M, Ontiveros F, Fitzgerald TJ, et al (2012). IL-1 generated subsequent to radiation-induced tissue injury contributes to the pathogenesis of radiodermatitis. Radiat Res, 178, 166-2.   DOI
197 Jelveh S, Kaspler P, Bhogal N, e al (2013). Investigations of antioxidant-mediated protection and mitigation of radiationinduced DNA damage and lipid peroxidation in murine skin. Int J Radiat Biol, 89, 618-7.   DOI   ScienceOn
198 Jiang F, Dusting GJ (2003). Natural phenolic compounds as cardiovascular therapeutics: potential role of their antiinflammatory effects. Review. Curr Vasc Pharmacol, 1, 135-56.   DOI
199 Jiang YJ, Teichert AE, Fong F, Oda Y, Bikle DD (2013). 1$\alpha$,25(OH)2-dihydroxyvitamin D3/VDR protects the skin from UVB-induced tumor formation by interacting with the $\beta$-catenin pathway. J Steroid Biochem Mol Biol, 136, 229-2.   DOI   ScienceOn
200 Srinivasan M, Rajendra Prasad N, Menon VP (2006). Protective effect of curcumin on gamma-radiation induced DNA damage and lipid peroxidation in cultured human lymphocytes. Mutat Res, 611, 96-3.   DOI   ScienceOn
201 Srinivasan R, Chandrasekar MJ, Nanjan MJ, Suresh B (2007). Antioxidant activity of Caesalpinia digyna root. J Ethnopharmacol, 113, 284-1.   DOI   ScienceOn
202 Suleyman H, Gumustekin K, Taysi S (2002). Beneficial effects of Hippophae rhamnoides L on nicotine induced oxidative stress in rat blood compared with vitamin E. Biol Pharm Bull, 25, 1133-6.   DOI   ScienceOn
203 Sun Y, Tang J, Gu X, Li D (2005). Water-soluble polysaccharides from AngelicA. sinensis (Oliv.) Diels: Preparation, characterization and bioactivity. Int J Biol Macromol, 36, 283-9.   DOI   ScienceOn
204 Sharan RN, OdyuomM, Purkayastha, S (2011). Oxygen free radicals and its biomedical implications: A mini review. Mini Rev Org Chem, 8, 372-6.   DOI
205 Samarth RM, Panwar M, Kumar M, et al (2008). Evaluation of antioxidant and radical-scavenging activity of certain radioprotective plant extracts. Food Chem, 106, 868-3.   DOI   ScienceOn
206 Samarth RM, Samarth M (2009). Protection against radiationinduced testicular damage in swiss albino mice by Mentha piperita (Linn.). Basic Clin Pharmacol Toxicol, 104, 329-4.   DOI   ScienceOn
207 Samojlik I, Petkovic S, Mimica-Dukic N, Bozin B (2012). Acute and chronic pretreatment with essential oil of peppermint (Mentha piperita L, Lamiaceae) influences drug effects. Phytother Res, 26, 820-5.   DOI
208 Sharma A, Sharma MK, Kumar M (2007). Protective effect of Mentha piperita against arsenic-induced toxicity in liver of Swiss albino mice. Basic Clin Pharmacol Toxicol, 100, 249-7.   DOI
209 Hassan HA, Hafez HS, Goda MS (2013). Mentha piperita as a pivotal neuro-protective agent against gamma irradiation induced DNA fragmentation and apoptosis : mentha extract as a neuroprotective against gamma irradiation. Cytotechnology, 65, 145-56.   DOI   ScienceOn
210 Hei TK, Zhao Y, Zhou H, Ivanov V (2011). Mechanism of radiation carcinogenesis: role of the TGFBI gene and the inflammatory signaling cascade. Adv Exp Med Biol, 720, 163-0.   DOI
211 Haston CK, Begin M, Dorion G, Cory SM (2007). Distinct loci influence radiation-induced alveolitis from fibrosing alveolitis in the mouse. Cancer Res, 67, 10796-3.   DOI   ScienceOn
212 Hatcher H, Planalp R, Cho J, Torti FM, Torti SV (2008). Curcumin: from ancient medicine to current clinical trials. Cell Mol Life Sci, 65, 1631-52.   DOI   ScienceOn
213 Hill RP, Zaidi A, Mahmood J, Jelveh S (2011). Investigations into the role of inflammation in normal tissue response to irradiation. Radiother Oncol, 101, 73-9.   DOI   ScienceOn
214 Horton JA, Hudak KE, Chung EJ, et al (2013). Mesenchymal stem cells inhibit cutaneous radiation-induced fibrosis by suppressing chronic inflammation. Stem Cells, 31, 2231-1.   DOI
215 Hussain A, Shadma W, Maksood A, Ansari SH (2013). Protective effects of Picrorhiza kurroa on cyclophosphamide-induced immunosuppression in mice. Pharmacognosy Res, 5, 30-5.
216 Jagetia GC (2007). Radioprotection and radiosensitization by curcumin. Review. Adv Exp Med Biol, 595, 301-20.   DOI
217 Jagetia GC (2007). Radioprotective potential of plants and herbs against the effects of ionizing radiation. J Clin Biochem Nutr, 40, 74-1.   DOI   ScienceOn
218 Sharma M, Kumar M (2007). Radioprotection of Swiss albino mice by Myristica fragrans houtt. J Radiat Res, 48, 135-1.   DOI   ScienceOn
219 Sharma KK, Milligan JR, Bernhard WA (2008). Multiplicity of DNA single-strand breaks produced in pUC18 exposed to the direct effects of ionizing radiation. Radiat Res, 170, 156-2.   DOI
220 Sharma KK, Razskazovskiy Y, Purkayastha S, Bernhard WA (2009). Mechanisms of strand break formation in DNA due to the direct effect of ionizing radiation: the dependency of free base release on the length of alternating CG oligodeoxynucleotides. J Phys Chem B, 113, 8183-1.   DOI
221 Shukla SK, Chaudhary P, Kumar IP, et al (2006). Protection from radiation-induced mitochondrial and genomic DNA damage by an extract of Hippophae rhamnoides. Environ Mol Mutagen, 47, 647-6.   DOI
222 Gupta ML, Tyagi S, Flora SJ, et al (2007). Protective efficacy of semi purified fraction of high altitude Podophyllum hexandrum rhizomes in lethally irradiated Swiss albino mice. Cell Mol Biol, 53, 29-41.
223 Jagetia GC, Venkatesh P (2005). Radioprotection by oral administration of Aegle marmelos (L.) correa in vivo. J Environ Pathol Toxicol Oncol, 24, 315-32.   DOI
224 Habermehl D, Kammerer B, Handrick R, et al (2006). Proapoptotic activity of Ukrain is based on Chelidonium majus L. alkaloids and mediated via a mitochondrial death pathway. BMC Cancer, 6, 14-35.   DOI
225 Gupta ML, Sankhwar S, Verma S, et al (2008). Whole body protection to lethally irradiated mice by oral administration of semipurified fraction of podophyllum hexandrum and post irradiation treatment of Picrorhiza kurroa. Tokai J Exp Clin Med, 33, 6-12.
226 Ha CT, Li XH, Fu D, Xiao M, Landauer MR (2013). Genistein nanoparticles protect mouse hematopoietic system and prevent proinflammatory factors after gamma irradiation. Radiat Res, 180, 316-5.   DOI   ScienceOn
227 Han G, Zhou YF, Zhang MS, et al (2006). AngelicA. sinensis down-regulates hydroxyproline and TGF-$\beta$1 and provides protection in mice with radiation-induced pulmonary fibrosis. Radiat Res, 165, 546-2.   DOI   ScienceOn
228 Han Y, Son SJ, Akhalaia M, et al (2005). Modulation of radiationinduced disturbances of antioxidant defense systems by ginsan. Evid Based Complement Alternat Med, 2, 529-6.   DOI   ScienceOn
229 Han Y, Wang Y, Xu HT, et al (2009). X-radiation induces nonsmall- cell lung cancer apoptosis by upregulation of axin expression. Int J Radiat Oncol Biol Phys, 75, 518-6.   DOI   ScienceOn
230 Ramachandran L, Nair CK (2011). Protection against genotoxic damages following whole body gamma radiation exposure in mice by lipoic acid. Mutat Res, 724, 52-8.   DOI   ScienceOn
231 Kulp M, Bragina O (2013). Capillary electrophoretic study of the synergistic biological effects of alkaloids from Chelidonium majus L. in normal and cancer cells. Anal Bioanal Chem, 405, 3391-7.   DOI   ScienceOn
232 Gottfredsen RH, Goldstrohm DA, Hartney JM, et al (2014). The cellular distribution of extracellular superoxide dismutase in macrophages is altered by cellular activation but unaffected by the natural occurring R213G substitution. Free Radic Biol Med, Feb 7, [Epub ahead of print].
233 Yang X, Zhao Y, Zhou Y, et al (2007). Component and antioxidant properties of polysaccharide fractions isolated from AngelicA. sinensis (OLIV.) DIELS. Biol Pharm Bull, 30, 1884-0.   DOI   ScienceOn