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http://dx.doi.org/10.7314/APJCP.2014.15.5.2273

Bioinformatics Analysis Reveals Significant Genes and Pathways to Targetfor Oral Squamous Cell Carcinoma  

Jiang, Qian (Department of Stomatology, Zhongshan Hospital, Fudan University)
Yu, You-Cheng (Department of Stomatology, Zhongshan Hospital, Fudan University)
Ding, Xiao-Jun (Department of Stomatology, Zhongshan Hospital, Fudan University)
Luo, Yin (Department of Stomatology, Zhongshan Hospital, Fudan University)
Ruan, Hong (Department of Stomatology, Zhongshan Hospital, Fudan University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.5, 2014 , pp. 2273-2278 More about this Journal
Abstract
Purpose: The purpose of our study was to explore the molecular mechanisms in the process of oral squamous cells carcinoma (OSCC) development. Method: We downloaded the affymetrix microarray data GSE31853 and identified differentially expressed genes (DEGs) between OSCC and normal tissues. Then Gene Ontology (GO) and Protein-Protein interaction (PPI) networks analysis was conducted to investigate the DEGs at the function level. Results: A total 372 DEGs with logFCI >1 and P value < 0.05 were obtained, including NNMT, BAX, MMP9 and VEGF. The enriched GO terms mainly were associated with the nucleoplasm, response to DNA damage stimuli and DNA repair. PPI network analysis indicated that GMNN and TSPO were significant hub proteins and steroid biosynthesis and synthesis and degradation of ketone bodies were significantly dysregulated pathways. Conclusion: It is concluded that the genes and pathways identified in our work may play critical roles in OSCC development. Our data provides a comprehensive perspective to understand mechanisms underlying OSCC and the significant genes (proteins) and pathways may be targets for therapy in the future.
Keywords
Bioinformatics; oral SCC; differentially expressed genes; protein-protein interactions; pathways;
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