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http://dx.doi.org/10.7314/APJCP.2014.15.5.2185

Gonadotrophin Releasing Hormone Analogues for Ovarian Function Preservation in Young Females Undergoing Chemotherapy  

Bansal, Anshuma (Radiation Oncology, Medical Education and Research)
Patel, Firuza Darius (Radiation Oncology, Medical Education and Research)
Rai, Bhavana (Radiation Oncology, Medical Education and Research)
Dhanireddy, Bhaswanth (Radiation Oncology, Medical Education and Research)
Sharma, Suresh Chand (Radiation Oncology, Medical Education and Research)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.5, 2014 , pp. 2185-2190 More about this Journal
Abstract
Chemotherapy has significantly improved the prognosis of cancer patients with various malignancies. However, female patients, especially those whoich are premenopausal, suffer from significant chemotherapy induced ovarian function impairment, which decreases their quality of life. Many new techniques for ovarian preservation have been established in recent years. Although the use of gonadotrophin releasing hormone analogues (GnRHa) for this purpose is not a new concept, its effectiveness in protection of ovarian function is still debatable. This article deals with studies and metaanalyses which have been undertaken in the past, demonstrating the impact of GnRHa in ovarian function preservation, and whether their use can be implemented in routine practice.
Keywords
Hemotherapy; gonadotrophin releasing hormone analogues; ovarian failure; gonadotoxicity;
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