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http://dx.doi.org/10.7314/APJCP.2014.15.5.1905

Ionizing Radiations Induce Apoptosis in TRAIL Resistant Cancer Cells: in vivo and in vitro Analysis  

Silva, Marcela Fernandes (Universidade Estadual de Maringa)
Khokhar, Abdur Rehman (Department of Radiology, RLMC)
Qureshi, Muhammad Zahid (Department of Chemistry, GCU)
Farooqi, Ammad Ahmad (Laboratory for Translational Oncology and Personalized Medicine, RLMC)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.5, 2014 , pp. 1905-1907 More about this Journal
Abstract
Increasingly it is being realized that despite considerable advancements in therapeutic interventions related to treatment of cancer, satisfactory results are still difficult to achieve. Rapidly accumulating evidence has started to shed light on the fact that cancer cells escape from death via constitutive activation of pro-survival signaling cascades. Cell biology and genetics have extensively enhanced our current understanding of the molecular mechanisms that underlie loss of apoptosis in cancer cells. This review is focused on ionizing radiation mediated restoration of TRAIL mediated apoptosis as evidenced by cell culture and animal model studies. Moreover, we also bring to the limelight radiation induced expression of miRNAs and how miRNAs further control response of cancer cells to radiation.
Keywords
Ionizing radiation; TRAIL; apoptosis;
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