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http://dx.doi.org/10.7314/APJCP.2014.15.4.1767

In Vitro and in Vivo Antitumor Evaluation of Berbamine for Lung Cancer Treatment  

Hou, Zhi-Bo (First Department of Respiratory Medicine, Nanjing Chest Hospital & Clinical Center of Nanjing Respiratory Diseases)
Lu, Kai-Jin (Department of Thoracic Surgery, Jiangsu Taizhou People's Hospital)
Wu, Xiao-Li (Department of Women Health Care, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University)
Chen, Cong (Department of Gynecology of Traditional Chinese Medicine, Jiangsu Provincial Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Traditional Chinese Medicine)
Huang, Xin-En (Department of Chemotherapy, JiangSu Cancer Hospital & Research Institute)
Yin, Hai-Tao (Department of Radiotherapy, the Central Hospital of Xuzhou, Affiliated Hospital of Southeast University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.4, 2014 , pp. 1767-1769 More about this Journal
Abstract
Purpose: Lung cancer, one of the most frequently diagnosed cancers in the world, is characterized by relatively high morbidity and mortality. Berbamine (BER) has been initially reported to exert anti-proliferative effects against a series of cancers. Methods: In this study the in vitro cytotoxicity of BER was measured by MTT assay. In vivo anti-cancer efficacy of BER was assessed in A549 xenografts. Results: Cytotoxicity tests showed dose-dependent cell growth inhibition effects of BER against A549 cells. Moreover, BER significantly reduced the growth of lung cancer in a dose-dependent manner in nude mice with prolonged survival time. Conclusion: Therefore, BER might be in herbal medicine for cancer therapy and further efforts are needed to explore therapeutic strategies.
Keywords
Berbamine; antitumor; lung cancer; therapy;
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