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http://dx.doi.org/10.7314/APJCP.2014.15.2.1057

Potential Study Perspectives on Mechanisms and Correlations Between Adiposity and Malignancy  

Lu, Kun (Shanghai Tenth People's Hospital, Tongji University School of Medicine)
Song, Xiao-Lian (Shanghai Tenth People's Hospital, Tongji University School of Medicine)
Han, Shi-Long (Shanghai Tenth People's Hospital, Tongji University School of Medicine)
Wang, Chang-Hui (Shanghai Tenth People's Hospital, Tongji University School of Medicine)
Zhong, Ni (Shanghai Tenth People's Hospital, Tongji University School of Medicine)
Qi, Li-Feng (The Institute for Biomedical Engineering & Nano Science (iNANO), Tongji University School of Medicine)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.2, 2014 , pp. 1057-1060 More about this Journal
Abstract
Adiposity is a well-recognized risk factor of type 2 diabetes and cardiovascular disease, and recently there is increasing evidence that excess body weight is an avoidable cause of cancer, including gastrointestinal, endometrial, esophageal adenocarcinoma, colorectal, postmenopausal breast, prostate, and renal malignancies. The mechanisms whereby adiposity is associated with tumor development remains not well understood. There are some most studied hypothesized mechanisms such as, high levels of insulin and free levels of insulin-like growth factors, sex hormones, adipocytokines, and inflammatory cytokines, adiposity-induced hypoxia, and so on. The potential mechanisms and conclusions in adiposity associated with increased risk for developing malignancy, and the underlying cellular and molecular mechanisms will be studied very well in the near future.
Keywords
Perspectives; adiposity; malignancy;
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1 McTiernan A (2000). Associations between energy balance and body mass index and risk of breast carcinoma in women from diverse racial and ethnic backgrounds in the U.S. Cancer, 88 (5 Suppl), 1248-55.   DOI
2 WHO/NUT/NCD (2000). Obesity: Preventing and Managing the Global Epidemic. Report of a WHO Consultation in Obesity. WHO TRS 894: Geneva.
3 Wolf AM and Colditz GA (1998). Current Estimates of the Economic Cost of Obesity in the United States. Obes Res, 6, 97-106.   DOI   ScienceOn
4 Johnson IT and Lund EK (2007). Review article: nutrition, obesity and colorectal cancer. Aliment Pharmaco Ther, 26, 161-81.
5 Lundell L, Ruth M, Sandberg N and Bove-Nielsen M (1995). Does massive obesity promote abnormal gastroesophageal reflux? Dig Dis Sci, 40, 4632-5.
6 Martinez ME, Giovannucci E, Spiegelman D, et al (1997). Leisure-time physical activity, body size, and colon cancer in women. Nurses' Health Study Research Group. J Natl Cancer Inst, 89, 948-55.   DOI   ScienceOn
7 Moghaddam AA, Woodward M and Huxley R (2007). Obesity and risk of colorectal cancer: a meta-analysis of 31 studies with 70, 000 events.Cancer Epidemiol Biomarkers Prev, 16, 2533-47.   DOI   ScienceOn
8 Murphy K, Calle EE, Rodriguez C, et al (2000). Body mass index and colon cancer mortality in a large prospective study. Am J Epidemiol, 152, 847-54.   DOI   ScienceOn
9 Rose PG (1996). Endometrial carcinoma. N Engl J Med, 335, 640-9.   DOI   ScienceOn
10 Skibola CF (2007). Obesity, diet and risk of non-Hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev, 16, 392-5.   DOI   ScienceOn
11 Stene-Larsen G, Weberg R, Larsen I, et al (1988). Relationship of overweight to hiatus hernia and ux oesophagitis. Scand J Gastroenterol, 23, 427-32.   DOI   ScienceOn
12 Van Gaal LF and Mertens I (1998). Effects of obesity on cardiovascular system and blood pressure control, digestive disease and cancer, in Clinical Obesity (eds P. Kopelman and M. Stock), Blackwell Science, Oxford, pp. 205-25.
13 Verrijken A, Demunck S, Mertens I and Van Gaal L (2006). Overgewicht, obesitas en kanker. Tijdschr Genees, 62, 1304-11.   DOI
14 Bird CL, Frankl HD, Lee ER and Haile RW (1998). Obesity, weight gain, large weight changes, and adenomatous polyps of the left colon and rectum. Am J Epidemiol, 147, 670-80.   DOI   ScienceOn
15 Barnard RJ, Aronson WJ, Tymchuk CN and Ngo TH (2002). Prostate cancer: another aspect of the insulin-resistance syndrome? Obes Rev, 3, 303-8.   DOI   ScienceOn
16 Batty GD, Shipley M, Jarrett RJ, et al (2005). 0besity and overweight in relation to disease-specific mortality in men with and without existing coronary heart disease in London: the original Whitehall study. Int J Obes, 29, 1267-74.   DOI
17 Bergstrom A, Pisani P, Tenet V, et al (2001). Over-weight as an avoidable cause of cancer in Europe. Int J Cancer, 91 (3), 421-30.   DOI
18 Bray GA (2002). The underlying basis for obesity: relationship to cancer. J Nutr, 132, S3451-5.
19 Calle EE, Rodriguez C, Walker-Thurmond K and Thun MJ (2003). Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults. N Engl J Med, 348, 1625-38.   DOI   ScienceOn
20 Eliassen AH, Colditz GA, Rosner B, et al (2006). Adult weight change and risk of postmenopausal breast cancer. J Am Med Assoc, 296, 193-201.   DOI   ScienceOn
21 Giovannucci E, Ascherio A, Rimm EB, et al (1995). Physical activity, obesity, and risk for colon cancer and adenoma in men. Annal Int Med, 122, 327-34.   DOI   ScienceOn
22 IARC (2002). Weight Control and Physical Activity, IARC Press, Lyon. IARC Handbooks of Cancer Prevention, Vol 6..
23 James WPT, Jackson-Leach R, Ni Mhurchu C, et al (2004). Comparative quantification of health risks: Global and regional burden of disease attributable to selected major risk factors, Vol. 1. Ezzati M, Lopez A, Roge A and Murray C (eds). WHO: Geneva, pp. 495-596.