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http://dx.doi.org/10.7314/APJCP.2014.15.22.9835

Interference of Fisetin with Targets of the Nuclear Factor-κB Signal Transduction Pathway Activated by Epstein-Barr Virus Encoded Latent Membrane Protein 1  

Li, Rong (Department of Pathology and Pathophysiology, School of Basic Medicine Science)
Liang, Hong-Ying (Laboratory of Physiological Science, Guangdong Medical College)
Li, Ming-Yong (Department of Pathology and Pathophysiology, School of Basic Medicine Science)
Lin, Chun-Yan (Laboratory of Physiological Science, Guangdong Medical College)
Shi, Meng-Jie (Department of Pathology and Pathophysiology, School of Basic Medicine Science)
Zhang, Xiu-Juan (Department of Physiology, School of Basic Medicine Science)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.22, 2014 , pp. 9835-9839 More about this Journal
Abstract
Fisetin is an effective compound extracted from lacquer which has been used in the treatment of various diseases. Preliminary data indicate that it also exerts specific anti-cancer effects. However, the manner in which fisetin regulates cancer growth remains unknown. In this study, we elucidated interference of fisetin with targets of the nuclear factor ${\kappa}B$ signal transduction pathway activated by Epstein-Barr virus encoding latent membrane protein 1 (LMP1)in nasopharyngeal carcinoma (NPC) cells, Results showed that fisetin inhibited the survival rate of CNE-LMP1 cells and NF-${\kappa}B$ activation caused by LMP1. Fisetin also suppressed nuclear translocation of NF-${\kappa}B$ (p65) and $I{\kappa}B{\alpha}$ phosphorylation, while inhibiting CyclinD1, all key targets of the NF-${\kappa}B$ signal transduction pathway. It was suggested that interference effects of fisetin with signal transduction activated by LMP1 encoded by the Epstein-Barr virus may play an important role in its anticancer potential.
Keywords
Fisetin; nasopharyngeal carcinoma; latent membrane protein 1; NF-${\kappa}B$;
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Times Cited By KSCI : 2  (Citation Analysis)
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