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http://dx.doi.org/10.7314/APJCP.2014.15.22.9763

Ifosfamide-containing Regimens for Treating Patients with Osteosarcomas  

Li, Yan-Yan (Department of Neurology, The Second People Hospital of Mudanjiang)
Jiang, Xiao-Ming (Intensive Care Unit.)
Dong, Yi-Guo (Department of Radiology, Hongqi Hospital, Mudanjiang Medical University)
Xu, Gang (Department of Orthopaedics, Hongqi Hospital, Mudanjiang Medical University)
Ma, Yu-Bo (Department of Orthopaedics, Hongqi Hospital, Mudanjiang Medical University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.22, 2014 , pp. 9763-9766 More about this Journal
Abstract
Background: This systemic analysis was conducted to evaluate the efficacy and safety of an ifosfamide-containing regimen in treating patients with osteosarcoma. Methods: Clinical studies evaluating the efficacy and safety of Ifosfamide-containing regimen on response and safety for patients with osteosarcoma were identified by using a predefined search strategy. Pooled response rate (RR) of treatment were calculated. Results: When ifosfamide-containing regimens were evaluated, 4 clinical studies which including 134 patients with osteosarcoma were considered eligible for inclusion. Systemic analysis suggested that, in all patients, pooled RR was 44.8% (60/134) in ifosfamide-containing regimens. Major adverse effects were neutropenia, leukopenia, and fatigue inIfosfamide-containing regimens; No treatment related death occurred in cantharidin combined regimens. Conclusion: This systemic analysis suggests that ifosfamide-containing regimens are associated with good response rate and acceptable toxicity in treating patients with osteosarcoma, but this result should be confirmed by randomized clinical trials.
Keywords
Ifosfamide; osteosarcoma; toxicity; adverse effects; response rate;
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