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http://dx.doi.org/10.7314/APJCP.2014.15.22.9707

Lack of Association between Polymorphisms in Genes MTHFR and MDR1 with Risk of Childhood Acute Lymphoblastic Leukemia  

Kreile, Madara (Riga Stradins University)
Rots, Dmitrijs (Riga Stradins University)
Piekuse, Linda (Riga Stradins University)
Cebura, Elizabete (Children Clinical University Hospital)
Grutupa, Marika (Children Clinical University Hospital)
Kovalova, Zhanna (Riga Stradins University)
Lace, Baiba (Latvian Biomedical Research and Study Centre)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.22, 2014 , pp. 9707-9711 More about this Journal
Abstract
Background: Acute lymphoblastic leukemia (ALL) is a complex disease caused by interactions between hazardous exogenous or/and endogenous agents and many mild effect inherited susceptibility mutations. Some of them are known, but their functional roles still requireinvestigation. Age is a recognized risk factor; children with disease onset after the age of ten have worse prognosis, presumably also triggered by inherited factors. Materials and Methods: The MDR1 gene polymorphisms rs1045642, rs2032582 and MTHFR gene polymorphisms rs1801131 and rs1801133 were genotyped in 68 ALL patients in remission and 102 age and gender matched controls; parental DNA samples were also available for 42 probands. Results: No case control association was found between analyzed polymorphisms and a risk of childhood ALL development. Linkage disequilibrium was not observed in a family-based association study either. Only marginal association was observed between genetic marker rs2032582A and later disease onset (p=0.04). Conclusions: Our data suggest that late age of ALL onset could be triggered by mild effect common alleles.
Keywords
Lymphoblastic leukemia; childhood cases; MDR1; MTHFR; polymorphisms;
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