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http://dx.doi.org/10.7314/APJCP.2014.15.22.9621

XRCC3 Thr241Met Gene Polymorphism and Risk of Colorectal Cancer in Kashmir: a Case Control Study  

Nissar, Saniya (Department of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences)
Sameer, Aga Syed (Department Biochemistry, Sher-I-Kashmir Institute of Medical Sciences Associated Medical College)
Lone, Tufail A. (Department General Surgery, Sher-I-Kashmir Institute of Medical Sciences)
Chowdri, Nissar A. (Department General Surgery, Sher-I-Kashmir Institute of Medical Sciences)
Rasool, Roohi (Department of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.22, 2014 , pp. 9621-9625 More about this Journal
Abstract
XRCC (X-ray cross-complementing group) genes contribute to important DNA repair mechanisms that play roles in the repair of single strand breaks (SSBs) induced by a variety of external and internal factors, including ionizing radiation, alkylating agents and reactive oxygen species. These repair genes have a pivotal role in maintaining genomic stability through different pathways of base excision repair (BER). The aim of this study was to investigate the XRCC3 Thr241Met gene polymorphism in colorectal cancer (CRC) in Kashmir. We investigated the genotype distribution of XRCC3 gene in 120 CRC cases in comparison with 150 healthy subjects and found a significant association between XRCC3 genotypes and CRC ($p{\leq}0.05$). Both heterozygous genotype (Thr/Met) as well as homozygous variant genotype (Met/Met) were moderately associated with elevated risk of CRC [OR=2.53; OR=2.29 respectively]. Also, Thr/Met and Met/Met genotypes demonstrated a significant association with the risk of CRC (p = 0.003). This study displayed a significantly elevated risk for CRC in individuals with XRCC3 Thr/Met and Met/Met Genotype of about 2.5 times that with the Thr/Thr wild genotype.
Keywords
Colorectal cancer; XRCC3; polymorphism; PCR-RFLP; Kashmir;
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