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http://dx.doi.org/10.7314/APJCP.2014.15.21.9385

Association of Adiponectin Receptor (Adipo-R1/-R2) Expression and Colorectal Cancer  

Ayyildiz, Talat (Department of Gastroenterology, Medical Faculty, Ondokuz Mayis University)
Dolar, Enver (Department of Gastroenterology, Medical Faculty, Uludag University)
Ugras, Nesrin (Department of Pathology, Medical Faculty, Uludag University)
Adim, Saduman Balaban (Department of Pathology, Medical Faculty, Uludag University)
Yerci, Omer (Department of Pathology, Medical Faculty, Uludag University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.21, 2014 , pp. 9385-9390 More about this Journal
Abstract
Introduction: Human adiponectin (ApN) is a 30 kDa glycoprotein of 244-amino acids which is extensively produced by adipocytes. ApN acts via two receptors, namely adiponectin receptor-1 (Adipo-R1) and adiponectin receptor-2 (Adipo-R2). Studies have shown the presence of Adipo-R1 and Adipo-R2 expression immunohistochemically in human colorectal cancers (CRCs). However, only a few studies exist which investigated effects of adiponectin receptor expression on CRC characteristics. Objectives: In the present study, we aimed to explore Adipo-R1/-R2 expression in human colorectal cancers and any association with clinicopathological characteristics and survival. Materials and Methods: The study enrolled 58 colorectal cancer patients with tumor resection and a control group of 30 subjects with normal colon mucosa. Results: Positivity for Adipo-R1/-R2 expression was significantly more common in the control group in comparison to the patient group (both p<0.001). There was no significant association between Adipo-R1/-R2 expression and clinicopathological characteristics including age, sex tumor location, pTNM stage, Duke's stage, metastasis, histological differentiation, perineural invasion, venous invasion sex, lymphatic invasion, cancer-related mortality, tumor size and recurrence. Adipo- R1/-R2 positivity was also not significantly linked to progression-free or overall survival [p values (0.871, 0.758) and (0.274, 0.232), respectively]. Conclusions: Although significantly reduced Adipo-R1/-R2 expression was found in colorectal cancer patients, it had no influence on survival.
Keywords
Adiponectin receptor; Adipo-R1/-R2; colorectal carcinoma; prognosis;
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