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http://dx.doi.org/10.7314/APJCP.2014.15.1.419

Metastatic Lymphadenopathy in Kashmir Valley: A Clinicopathological Study  

Qadri, Sumyra Khurshid (Department of Pathology, Sher-i-Kashmir Institute of Medical Sciences)
Hamdani, Nissar Hussain (Department of Surgical Gastroenterology, The Calcutta Medical Research Institute)
Shah, Parveen (Department of Pathology, Sher-i-Kashmir Institute of Medical Sciences)
Baba, Khalil Mohammad (Department of Pathology, Sher-i-Kashmir Institute of Medical Sciences)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.1, 2014 , pp. 419-422 More about this Journal
Abstract
Background: Lymphadenopathy is a common presentation in both benign and malignant diseases which need to be diagnosed without delay. Fine needle aspiration cytology (FNAC) helps us diagnose a disease and follow its course, including the response to therapy. Aim: This study aimed to analyze the clinicopathological features of metastatic lymphadenopathy and the diagnostic utility of FNAC in our setting. Materials and Methods: This two-year prospective study included all the patients with metastatic lymphadenopathy, diagnosed with FNAC. Results: A total of 412 cases (male:female ratio, 1.3:1; age range, 3 to 90 years) were studied. Supraclavicular lymph nodes were involved most commonly (50.5%). The commonest metastatic tumor was squamous cell carcinoma in general (30.1%) and in males (37.6%), and infiltrating ductal carcinoma (25.3%) in females. Lung, with 64 (15.5%) cases followed by esophagus, 60 (14.6%) cases; breast, 49 (11.9%) cases; skin, 32 (7.8%) cases; and stomach, 25 (6.1%) cases were the most common primary sites of malignancy. In 69 patients, excision biopsy was performed. Histopathological findings correlated well with that of cytology in all these cases. Conclusions: FNAC is an important tool in the diagnostic work up of metastatic lymphadenopathy, which in the hands of an experienced and skilful cytopathologist can avoid the need for excision biopsy.
Keywords
Metastatic; lymphadenopathy; lymph nodes; FNAC; Kashmir valley;
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1 Wilkinson AR, Mahore SD, Maimoon SA (2012). FNAC in the diagnosis of lymph node malignancies: A simple and sensitive diagnostic tool. Indian J Med Paediatr Oncol, 33, 21-4.   DOI   ScienceOn
2 Fatima S, Arshad S, Ahmed Z, Hasan SH (2011). Spectrum of cytological findings in patients with neck lymphadenopathyexperience in a tertiary care hospital in Pakistan. Asian Pac J Cancer Prev, 2, 1873-5.
3 Bhuyan MAH, Fakir MAY, Hossain ABMT, Huq AHMZ, Gupta S (2008). Role of fine needle aspiration cytology in the diagnosis of cervical lymphadenopathy. Bangladesh J Otorhinolaryngol, 14, 63-5.
4 Darnal HK, Karim N, Kamini K, Angela K (2005). The profile of lymphadenopathy in adults and children. Med J Malaysia, 60, 590-8.
5 Facundo DJ, Quionnez G, Ravinsky E (2003). Transmission electron microscopy of fine needle aspiration biopsies of metastasis; Accuracy of both techniques as established by biopsy diagnoses. Acta Cytol, 47, 457-61.   DOI
6 Ghartimagar D, Ghosh A, Ranabhat S, et al (2011). Utility of fine needle aspiration cytology in metastatic lymph nodes. J Pathol Nepal, 1, 92-5.
7 Hirachand S, Lakhey M, Akhter J, Thapa B (2009). Evaluation of fine needle aspiration cytology of lymph nodes in Kathmandu Medical College, Teaching hospital. Kathmandu Univ Med J, 7, 139-42.
8 Khajuria R, Goswami KC, Singh K, Dudey VK (2006). Pattern of lymphadenopathy on fine needle aspiration cytology in Jammu. JK Sci, 8, 157-9.
9 Mitra S, Ray S, Mitra PK (2011). Fine needle aspiration cytology of supraclavicular lymph nodes: Our experience over a threeyear period. J Cytol, 28, 108-10.   DOI   ScienceOn
10 Steel BL, Schwartz MR, Ramzy I (1995). Fine needle aspiration biopsy in diagnosis of lymphadenopathy in 1,103 patients. Role, limitations and analysis of diagnostic pitfalls. Acta Cytol, 39, 76-81.
11 Ageep AK (2012). Assessment of adult peripheral lymphadenopathy in Red Sea State, Sudan. Int J Trop Dis Health, 2, 24-32.
12 Ahmad SS, Akhtar S, Akhtar K, Naseem S, Mansoor T (2005). Study of fine needle aspiration cytology in lymphadenopathy with special reference to acid-fast staining in cases of tuberculosis. JK Science, 7, 1-4.
13 Ahmed N, Israr S, Ashraf MS (2009). Comparison of fine needle aspiration cytology (FNAC) and excision biopsy in the diagnosis of cervical lymphadenopathy. Pakistan J Surg, 25, 72-5.
14 Alam K, Khan A, Siddiqui F, et al (2010). Fine needle aspiration cytology (FNAC): A handy tool for metastatic lymphadenopathy. Int J Pathol, 10, 2.
15 Bagwan IN, Kane SV, Chinoy RF (2007). Cytologic evaluation of the enlarged neck node: FNAC utility in metastatic neck disease. Int J Pathol, 6, 2.
16 Hafez NH and Tahoun NS (2011). Reliability of fine needle aspiration cytology (FNAC) as a diagnostic tool in cases of cervical lymphadenopathy. J Egyptian Natl Cancer Inst, 23, 105-14.   DOI   ScienceOn