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http://dx.doi.org/10.7314/APJCP.2014.15.19.8367

Prognostic Value of Caveolin-1 Expression in Gastric Cancer: a Meta-analysis  

Ye, Yang (Department of Preventive Medicine, School of Medicine, Jiangsu University)
Miao, Shu-Han (Department of Health Care, the Fourth Affiliated Hospital of Jiangsu University)
Lu, Rong-Zhu (Department of Preventive Medicine, School of Medicine, Jiangsu University)
Zhou, Jian-Wei (Department of Molecular Cell Biology and Toxicology, Cancer Center, School of Public Health, Nanjing Medical University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.19, 2014 , pp. 8367-8370 More about this Journal
Abstract
The relationship between caveolin-1 (Cav-1) and clinicopathological characteristics of gastric cancer is controversial, although Cav-1 plays an important role in tumor metastasis. To evaluate the clinicopathological and prognostic value of expression in patients with gastric cancer, a meta-analysis was performed to investigate the impact on clinicopathological parameters and prognosis in gastric cancer cases. Studies assessing these parameters for Cav-1 in gastric cancer were identified up to June 2014. Finally, a total of six studies met the inclusion criteria. Our combined results showed that Cav-1 expression was significantly associated with the Lauren classification (pooled OR=0.603, 95% CI: 0.381-0.953, P=0.030). Furthermore, we found that Cav-1 expression predicted a better overall survival in gastric cancer patients (pooled OR=0.590, 95% CI: 0.360-0.970, P=0.038, fixed-effect). In conclusion, the overall data of the present meta analysis showed that Cav-1 expression was not correlated with clinicopathological features except for the Lauren classification. Simultaneously, Cav-1 overexpression predicted a better overall survival in gastric cancer. Cav-1 expression in tumors is a candidate positive prognostic biomarker for gastric cancer patients.
Keywords
Cav-1; gastric cancer; clinicopathological characteristics; prognosis;
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