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http://dx.doi.org/10.7314/APJCP.2014.15.19.8301

The -765G>C Polymorphism in the Cyclooxygenase-2 Gene and Digestive System Cancer: a Meta-analysis  

Zhao, Fen (Department of Pathophysiology, West China School of Preclinical and Forensic Medicine, Sichuan University)
Cao, Yue (Department of Physiology and Pathology, Basic Medicine College, Chengdu University of Traditional Chinese Medicine)
Zhu, Hong (Department of Abdominal Cancer, West China Hospital, Sichuan University)
Huang, Min (Department of Pathophysiology, West China School of Preclinical and Forensic Medicine, Sichuan University)
Yi, Cheng (Department of Abdominal Cancer, West China Hospital, Sichuan University)
Huang, Ying (Department of Pathophysiology, West China School of Preclinical and Forensic Medicine, Sichuan University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.19, 2014 , pp. 8301-8310 More about this Journal
Abstract
Background: Published data regarding associations between the -765G>C polymorphism in cyclooxygenase-2 (COX-2) gene and digestive system cancer risk have been inconclusive. The aim of this study was to comprehensively evaluate the genetic risk of the -765G>C polymorphism in the COX-2 gene for digestive system cancer. Materials and Methods: A search was performed in Pubmed, Medline (Ovid), Embase, CNKI, Weipu, Wanfang and CBM databases, covering all studies until Feb 10, 2014. Statistical analysis was performed using Revman5.2. Results: A total of 10,814 cases and 16,174 controls in 38 case-control studies were included in this meta-analysis. The results indicated that C allele carriers (GC+CC) had a 20% increased risk of digestive system cancer when compared with the homozygote GG (odds ratio (OR)=1.20, 95% confidence interval (CI), 1.00-1.44 for GC+CC vs GG). In the subgroup analysis by ethnicity, significant elevated risks were associated with C allele carriers (GC+CC) in Asians (OR = 1.46, 95% CI=1.07-2.01, and p=0.02) and Africans (OR=2.12, 95% CI=1.57-2.87, and p< 0.00001), but not among Caucasians, Americans and mixed groups. For subgroup analysis by cancer type (GC+CC vs GG), significant associations were found between the -765G>C polymorphism and higher risk for gastric cancer (OR=1.64, 95% CI=1.03-2.61, and p=0.04), but not for colorectal cancer, oral cancer, esophageal cancer, and others. Regarding study design (GC+CC vs GG), no significant associations were found in then population-based case-control (PCC), hospital-based case-control (HCC) and family-based case-control (FCC) studies. Conclusions: This meta-analysis suggested that the -765G>C polymorphism of the COX-2 gene is a potential risk factor for digestive system cancer in Asians and Africans and gastric cancer overall.
Keywords
Cyclooxygenase-2; digestive system cancer; meta-analysis; polymorphism;
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