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http://dx.doi.org/10.7314/APJCP.2014.15.19.8245

5,10-Methylenetetrahydrofolate Reductase Polymorphisms and Colon Cancer Risk: a Meta-analysis  

Fang, Xin-Yu (Epidemiology and Statistics, School of Public Health, Anhui Medical University)
Xu, Wang-Dong (Epidemiology and Statistics, School of Public Health, Anhui Medical University)
Huang, Qian (Epidemiology and Statistics, School of Public Health, Anhui Medical University)
Yang, Xiao-Ke (Epidemiology and Statistics, School of Public Health, Anhui Medical University)
Liu, Yan-Yan (Epidemiology and Statistics, School of Public Health, Anhui Medical University)
Leng, Rui-Xue (Epidemiology and Statistics, School of Public Health, Anhui Medical University)
Pan, Hai-Feng (Epidemiology and Statistics, School of Public Health, Anhui Medical University)
Ye, Dong-Qing (Epidemiology and Statistics, School of Public Health, Anhui Medical University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.19, 2014 , pp. 8245-8250 More about this Journal
Abstract
Previous studies investigating the association between 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and colon cancer risk have generated conflicting results. The aim of our meta-analysis was to clarify the precise association. A systematic literature search was conducted to identify all relevant studies. Pooled odds ratio (ORs) with 95% confidence interval (CI) were used to estimate the strength of the association. In this meta-analysis, a total of 13 articles, involving 5,386 cases and 8,017 controls met the inclusion criteria. Overall, a significant association was found between colon cancer risk and the MTHFR C667 polymorphism (TT vs CC+CT: OR=0.79; 95%CI=0.65-0.96; p=0.017). Stratification by ethnicity revealed that MTHFRC667 was associated with colon cancer risk in the non-Asian group (TT vs CC+CT:OR=0.77, 95%CI=0.68-0.89, p=0.000; TT vs CC: OR=0.84, 95%CI=0.73-0.97, p=0.016). Stratification by source of control indicated that MTHFR C667 also correlated with colon cancer risk in the population-based subgroup (TT vs CC: OR=0.85, 95%CI=0.74-0.97, p=0.017; TT vs CC+CT: OR=0.78, 95%CI=0.68-0.89, p=0.000) and hospital-based subgroup (TT vs CC+CT: OR=0.65, 95%CI=0.49-0.86, p=0.003). However, risk was significantly increased for MTHFR A1298C polymorphisms and colon cancer risk in hospital-based studies (C vs A: OR=1.52, 95%CI=1.26-1.83, p=0.000; CC+AC vs AA: OR=1.93, 95%CI=1.47-2.49, p=0.000) but reduced in population-based studies (CC vs AA: OR=0.83, 95%CI=0.70-0.99, p=0.042). In conclusion, the results of our meta-analysis suggest that the MTHFR C667 polymorphism is associated with reduced colon cancer risk, especially for non-Asian populations.
Keywords
5, 10-methylenetetrahydrofolate reductase; polymorphisms; colon cancer; meta-analysis; non-Asians;
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