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http://dx.doi.org/10.7314/APJCP.2014.15.18.7521

Amentoflavone Acts as a Radioprotector for Irradiated v79 Cells by Regulating Reactive Oxygen Species (ROS), Cell Cycle and Mitochondrial Mass  

Xu, Ping (Department of Pharmacy, Xinxiang Medical University)
Jiang, En-Jin (Institute of Radiation Medicine)
Wen, Si-Yuan (Institute of Radiation Medicine)
Lu, Dan-Dan (Institute of Radiation Medicine)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.18, 2014 , pp. 7521-7526 More about this Journal
Abstract
Radioprotective effects of amentoflavone were investigated by examining cell viability, apoptosis, cell cycling concentrations of intracellular ROS (reactive oxygen species), and relative mitochondrial mass by flow cytometry after $^{60}Co$ irradiation. Pretreatment with amentoflavone 24 hours prior to 8 Gy $^{60}Co$ ${\gamma}$-ray irradiation significantly inhibited apoptosis, promoted the G2 phase, decreased the concentration of ROS and mitochondrial mass. These results collectively indicate that amentoflavone is an effective radioprotective agent.
Keywords
Amentoflavone; radioprotector; ROS; mitochondrial mass; cell cycle;
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