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http://dx.doi.org/10.7314/APJCP.2014.15.17.7333

Prevalence and Genotype Distribution of Human Papillomavirus among Women from Henan, China  

Wang, Xiao-Chuan (Department of Clinical Laboratory, No. 150 Central Hospital of PLA)
Sun, Liang-Qi (Department of Clinical Laboratory, No. 150 Central Hospital of PLA)
Ma, Li (Department of Clinical Laboratory, No. 150 Central Hospital of PLA)
Li, Hua-Xin (Department of Clinical Laboratory, No. 150 Central Hospital of PLA)
Wang, Xiu-Li (Department of Clinical Laboratory, No. 150 Central Hospital of PLA)
Wang, Xin (Department of Obstetrics and Gynecology, No. 150 Central Hospital of PLA)
Yun, Tian (Department of pathology, No. 150 Central Hospital of PLA)
Meng, Nian-Long (Department of pathology, No. 150 Central Hospital of PLA)
Lv, Da-Le (Department of Clinical Laboratory, No. 150 Central Hospital of PLA)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.17, 2014 , pp. 7333-7336 More about this Journal
Abstract
Human papillomavirus (HPV) infection has been implicated as a causative of cervical cancer. In the present study, a total of 578 samples from females attending the gynecological outpatient clinic in Henan province, China, were collected and the HPV genotypes were detected by gene chip and flow-through hybridization. Overall, 44.5% (257/578) females were found to be HPV DNA positive, and the high risk HPV (HR-HPV) rate was 35.1% (203/578). The first peak of HR-HPV infection appeared in the >60 year-old group (55.0%), and the second was within the 51-55 year-old group (50.0%) (${\chi}^2$=19.497, p<0.05). HPV 16 was the most prevalent genotype (9.2%), followed by HPV 52 (7.8%), HPV 6 (6.9%), HPV 11 (5.9%) and HPV 42 (5.0%). The single type HPV infection was 30.4%, with the five majority prevalent genotype HPV 16 (16.5%), HPV 52 (14.3%), HPV 6 (12.6%), HPV 42 (8.6%), HPV 31 (5.1%). The multiple-type HPV infections were 14.0%, and HPV 16 was the most prevalent type (29.6%), followed by HPV 52 (24.7%), HPV 6 (22.2%), HPV 11 (22.2%), HPV 42 (17.3%) and HPV 39 (17.3%).
Keywords
Human papillomavirus; prevalence; genotype; Henan, China;
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