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http://dx.doi.org/10.7314/APJCP.2014.15.16.6787

Expression of Cyclooxygenase-2 (COX-2) in Colorectal Adenocarcinoma: an Immunohistochemical and Histopathological Study  

Mahmoud, Abla Sayed (Department of Oral Maxillofacial Sciences, Alfarabi College of Dentistry)
Umair, Ayesha (Department of Oral Maxillofacial Sciences, Alfarabi College of Nursing and Dentistry)
Azzeghaiby, Saleh Nasser (Department of Oral Maxillofacial Sciences, Alfarabi College of Nursing and Dentistry)
Alqahtani, Fahad Hussain (Department of Oral Maxillofacial Sciences, Alfarabi College of Nursing and Dentistry)
Hanouneh, Salah (Department of Oral Maxillofacial Sciences, Alfarabi College of Nursing and Dentistry)
Tarakji, Bassel (Department of Oral Maxillofacial Sciences, Alfarabi College of Nursing and Dentistry)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.16, 2014 , pp. 6787-6790 More about this Journal
Abstract
Background: The aim of this study was to evaluate cyclooxygenase-2 (COX-2) immunoreactivity in colorectal adenocarcinomas and to find correlations with different pathological features. Materials and Methods: This study included 35 cases of colorectal carcinoma foir which surgical colectomy specimens were collected. Immunohistochemical staining of COX-2 (cyclooxygenase-2) is done by using the Streptavidin-biotin technique. Results: This work reveals that COX-2 is positive in most cases of colorectal carcinoma and negative in normal colon tissue with statistically non significant relations between COX-2 immunostaining and different pathological features. Conclusions: Our data suggest over expression of COX-2 protein in colorectal carcinoma in contrast to normal mucosa, with a possible role in cell proliferation in carcinogenesis.
Keywords
COX-2; antibodies; colorectal adenocarcinoma; immunohistochemistry;
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