Browse > Article
http://dx.doi.org/10.7314/APJCP.2014.15.15.6301

Preliminary Evaluation of the in vitro Efficacy of 1, 2-di (Quinazolin-4-yl) Diselane against SiHa Cervical Cancer Cells  

Huang, Yin-Jiu (Department of Bioscience, Bengbu Medical College)
Zhang, Yu-Yuan (Department of Preventive Medicune, Bengbu Medical College)
Liu, Gang (School of Chemistry and Materials Science, Ludong University)
Tang, Jie (Scientific Research Center, Bengbu Medical College)
Hu, Jian-Guo (Scientific Research Center, Bengbu Medical College)
Feng, Zhen-Zhong (Department of Pathology, Bengbu Medical College)
Liu, Fang (Faculty of Pharmacy, Bengbu Medical College)
Wang, Qi-Yi (Scientific Research Center, Bengbu Medical College)
Li, Dan (Department of Bioscience, Bengbu Medical College)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.15, 2014 , pp. 6301-6306 More about this Journal
Abstract
Cervical cancer is one the most common malignancies among females. In recent years, its incidence rate has shown a rising trend in some countries so that development of anticancer drugs for cervical cancer is an urgent priority. In our recent anticancer drug discovery screen, 1, 2-di (quinazolin-4-yl)diselane (LG003) was found to possess wide spectrum anticancer efficacy. In the present work, the in vitro anticancer activity of LG003 was evaluated in the SiHa cervical cancer cell line. Compared with commercial anticancer drugs 10-hydroxycamptothecin, epirubicin hydrochloride, taxol and oxaliplatin, LG003 showed better anticancer activity. Furthermore, inhibition effects were time- and dose-dependent. Morphological observation exhibited LG003 treatment results in apoptosis like shrinking and blebbing, and cell membrane damage. Lactate dehydrogenase release assay revealed that LG003 exerts such effects in SiHa cells through a physiology pathway rather than cytotoxicity, which suggests that title compound LG003 can be a potential candidate agent for cervical cancer.
Keywords
1, 2-di (quinazolin-4-yl)diselane; cervical cancer; SiHa cells; anticancer activity;
Citations & Related Records
Times Cited By KSCI : 13  (Citation Analysis)
연도 인용수 순위
1 Baskaran P, Subramanian P, Rahman RA, et al (2013). Perceived susceptibility, and cervical cancer screening benefits and barriers in Malaysian women visiting outpatient clinics. Asian Pac J Cancer Prev, 14, 7693-9.   과학기술학회마을   DOI   ScienceOn
2 Berthier S, Bertrand MR, Ghirenghelli F, et al (2002). Elevation of serum lactate dehydrogenase. Diagnostic, prognostic and evolutive values. Presse Med, 31, 107-12 (in French).
3 Cadron I, Van Gorp T, Amant F, et al (2007). Chemotherapy for recurrent cervical cancer. Gynecol Oncol, 107, 113-8.   DOI   ScienceOn
4 Chen W, Zheng R, Zhang S, et al (2014). Annual report on status of cancer in china, 2010. Chin J Cancer Res, 26, 48-58.
5 Chiranjeevi P, Spurthi KM, Rani NS, et al (2014). Gelatinase B (-1562C/T) polymorphism in tumor progression and invasion of breast cancer. Tumour Biol, 35, 1351-6.   DOI
6 Ferlay J, Shin HR, Bray F, et al (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer, 127, 2893-917.   DOI   ScienceOn
7 Hu Y, Li M, Jia X, et al (2013). HPV16 CTL Epitope peptideactivated dendritic cell and natural killer co-culture for therapy of cervical cancer in an animal model. Asian Pac J Cancer Prev, 14, 7335-8.   DOI   ScienceOn
8 Huang Y, Liu F, Zhao L, et al (2012). The antitumor bioactivity of 4- (4-fluorophenyl)amino-5, 6, 7-trimethoxyquinazoline against tumor cells in vitro. Cell Biol Int, 36, 377-82.   DOI   ScienceOn
9 Huang Y, Liu G, Hu X, et al (2014). A potential anticancer agent 1, 2-di (quinazolin-4-yl)diselane. Lett Drug Des Discov, 11, 731-5.   DOI   ScienceOn
10 Huang Y, Su L, Wang H, et al (2012). Antitumor effect of N-(4-chlorophenyl)-5, 6, 7-trimethoxyquinazolin-4-amine dihydrochloride on tumor cells in vitro. Afr J Pharm Pharmaco, 6, 1536-44.
11 Kesic V (2006). Management of cervical cancer. Eur J Surg Oncol, 32, 832-37.   DOI   ScienceOn
12 Li N, Wang H, Fan J, et al (2014). Overexpression of 14-3-3θ promotes tumor metastasis and indicates poor prognosis in breast carcinoma. Oncotarget, 5, 249-57.
13 McRae J, Martin C, O'Leary J, et al (2014). “If you can't treat HPV, why test for it?” Women's attitudes to the changing face of cervical cancer prevention: a focus group study. BMC Women's Health, 14, 64.   DOI   ScienceOn
14 Mowa S. Rodriguez L, Arias-Pulido H, et al (2009). Novel chemotherpy approaches for cervical cancer. Cancer, 115, 3166-80.   DOI   ScienceOn
15 Rai B, Dhanireddy B, Patel FD, et al (2014). Toxicity and sexual outcomes in patients of cervical cancer undergoing image based brachytherapy. Asian Pac J Cancer Prev, 15, 3619-23.   과학기술학회마을   DOI   ScienceOn
16 Munoz N (2000). Human papillomavirus and cancer: the epidemological evidence. J Clin Virol, 19, 1-5.   DOI   ScienceOn
17 Natphopsuk S, Settheetham-Ishida W, Pientong C, et al (2013). Human papillomavirus genotypes and cervical cancer in Northeast Thailand. Asian Pac J Cancer Prev, 14, 6961-4.   과학기술학회마을   DOI   ScienceOn
18 Natphopsuk S, Settheetham-Ishida W, Sinawat S, et al (2012). Risk factors for cervical cancer in northeastern Thailand: detailed analyses of sexual and smoking behavior. Asian Pac J Cancer Prev, 13, 5489-95.   과학기술학회마을   DOI   ScienceOn
19 Sharma C, Nusri QE, Begum S, et al (2012). (-)-Epigallocatechin-3-gallate induces apoptosis and inhibits invasion and migration of human cervical cancer cells. Asian Pac J Cancer Prev, 13, 4815-22 .   과학기술학회마을   DOI   ScienceOn
20 Simayi D, Yang L, Li F, et al (2013). Implementing a cervical cancer awareness program in low-income settings in western china: a community-based locally affordable intervention for risk reduction. Asian Pac J Cancer Prev, 14, 7459-66.   과학기술학회마을   DOI   ScienceOn
21 Wongwatcharanukul L, Promthet S, Bradshaw P, et al (2014). Factors affecting cervical cancer screening uptake by Hmong hilltribe women in Thailand. Asian Pac J Cancer Prev, 15, 3753-6.   과학기술학회마을   DOI   ScienceOn
22 Srisuwan S, Hamontri S, Kongsomboon K, et al (2014). Seeand-treat approach to cervical intraepithelial lesions in HRH Princess Maha Chakri Sirindhorn Medical Center. Asian Pac J Cancer Prev, 15, 3483-6.   과학기술학회마을   DOI   ScienceOn
23 Wang H, Wu S, (2013). HPV vaccine knowledge and perceived risk of cervical cancer among female college students in Taiwan. Asian Pac J Cancer Prev, 14, 7371-4.   과학기술학회마을   DOI   ScienceOn
24 Wang Y, Li L, Wei S, et al (2013). Human papillomavirus (HPV) infection in women participating in cervical cancer screening from 2006 to 2010 in Shenzhen City, South China. Asian Pac J Cancer Prev, 14, 7483-7.   과학기술학회마을   DOI   ScienceOn
25 Yilmazel G, Duman NB, (2014). Knowledge, attitudes and beliefs about cervical cancer and human papilloma virus vaccination with related factors in Turkish university students. Asian Pac J Cancer Prev, 15, 3699-704.   과학기술학회마을   DOI   ScienceOn
26 Yoysungnoen-Chintana P, Bhattarakosol P, Patumraj S (2014). Antitumor and antiangiogenic activities of curcumin in cervical cancer xenografts in nude Mice. Biomed Res Int, 2014, 817972.
27 Zhang B, Zhou A, Zhu C, et al (2013). Risk factors for cervical cancer in rural areas of Wuhan China: a matched case-control Study. Asian Pac J Cancer Prev, 14, 7595-600.   과학기술학회마을   DOI   ScienceOn
28 Seki K, Tsuduki Y, Ioroi T, et al (2014). Serum lactate dehydrogenase levels as a predictive marker of oxaliplatininduced hupersensitivity reactions in Japanese patients with advanced colorectal cancer. Int J Med Sci, 11, 641-5.   DOI